A5102758583- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Urinary Bladder and Prostate Research
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Uterine Myomas and Treatments
- Chromatin Remodeling and Cancer
- Urinary Tract Infections Management
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Cervical Cancer and HPV Research
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Dermatology and Skin Diseases
- Endometriosis Research and Treatment
- Metastasis and carcinoma case studies
Kanazawa University
2021-2025
Osaka University
2018-2023
Akita University
2014-2023
Osaka Medical and Pharmaceutical University
2017-2020
The University of Tokyo
2007-2017
Royal Oak Community Coalition
2016
Experimental Pathology Laboratories
2015
Showa General Hospital
2014
Akita University Hospital
2014
University of Pittsburgh
2013
ARID1A is a recently identified tumor suppressor gene that mutated in approximately 50% of ovarian clear cell and 30% endometrioid carcinomas. The mutation associated with loss protein expression as assessed by immunohistochemistry. In this study, we evaluated immunoreactivity wide variety carcinomas to determine the prevalence inactivation Mutational analysis was carried out selected cases. Immunoreactivity not detected (corresponding or ARID1A) 36 (3.6%) 995 tumors. Uterine low-grade...
Abstract The clinical guidelines for interstitial cystitis and related symptomatic conditions were revised by updating our previous guidelines. current define cystitis/bladder pain syndrome as a condition with chronic pelvic pain, pressure or discomfort perceived to be the urinary bladder accompanied other symptoms, such persistent urge void frequency in absence of confusable diseases. characteristic symptom complex is collectively referred hypersensitive symptoms. Interstitial divided into...
Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, discomfort or pain of unknown etiology. Based on cystoscopic findings, patients IC are classified as either Hunner-type/classic (HIC), presenting specific Hunner lesion, non-Hunner-type (NHIC), no but post-hydrodistension mucosal bleeding. Inflammatory cell infiltration, composed predominantly lymphocytes, plasma cells and epithelial denudation, has in the past been documented major pathological finding. However,...
Recent genome-wide analysis has demonstrated that somatic mutations in ARID1A (BAF250) are the most common molecular genetic changes ovarian clear cell carcinoma (OCCC). mutations, which occur approximately half of OCCC cases, lead to deletion encoded protein and inactivation putative tumor suppressor. In this study, we determined significance loss immunoreactivity with respect several clinicopathological features a total 149 OCCCs. First, immunohistochemistry showed concordance mutational...
Up-regulated expression of telomerase reverse transcriptase (TERT) and subsequent maintenance telomere length are essential in tumour development. Recent studies have implicated somatic gain-of-function mutations at the TERT promoter as one mechanisms that promote transcriptional activation TERT; however, it remains unclear whether this genetic abnormality is prevalent gynaecological neoplasms. We performed mutational analysis a total 525 cancers, correlated with clinicopathological...
Morikawa T, Maeda D, Kume H, Homma Y & Fukayama M (2010) Histopathology 57, 885–892 Ribonucleotide reductase M2 subunit is a novel diagnostic marker and potential therapeutic target in bladder cancer Aims: To examine the immunohistochemical expression function of ribonucleotide (RRM2), gemcitabine‐related molecule, cancer. Methods results: One hundred seventeen specimens on tissue microarray were immunostained for RRM2. Positive RRM2 staining was observed none 14 examples non‐neoplastic...
We systematically characterized gene expression, inflammation and neovascularization in patients with interstitial cystitis/bladder pain syndrome to obtain biological evidence supporting diagnosis classification.We sequenced RNA obtained from bladder mucosal biopsies of 33 3 subtypes syndrome, including Hunner lesions 12, no 11 but glomerulations neither nor 10, 9 controls. Differentially expressed genes each subtype were searched identify specific pathways candidate important for...
Microcystic stromal tumor (MCST) is a recently described subtype of ovarian characterized by prominent microcystic histologic pattern and diffuse immunoreactivity for CD10 vimentin. However, its pathobiology, particularly histogenesis, remains largely unclear. Here, we report 2 cases MCST, in which have performed extensive histologic, immunohistochemical, genetic investigations to determine distinct nature among neoplasms. The patients were 32 41 years age. Both tumors solid cystic masses...
The histone methyltransferase EZH2, a key epigenetic modifier, is known to be associated with human tumorigenesis. However, the physiological importance of EZH2 and its clinical relevance in endometrial cancer remain unclear. Hence, present study, we investigated expression function cancer. In quantitative real-time PCR analysis 11 cell lines 52 specimens, was significantly overexpressed cells tissues compared that corresponding normal control tissues. Kaplan-Meier survival using data TCGA...
This study aimed to clarify claudin-6 expression patterns in cancers.We surveyed by immunohistochemistry using tissue microarray 860 tumours, including germ cell tumours and major carcinomas. Claudin-6 was expressed consistently (28 of 28, 100%), whereas only 64 (8%) 832 non-germ demonstrated expression. Further immunohistochemical full sections diffuse staining all seminomas (n=14), embryonal carcinomas (n=10), yolk sac (n=12) mononuclear trophoblastic cells choriocarcinomas (n=3), focal...
Abstract Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease conducting a genome-wide association study, followed two validation studies, 3,173 Japanese patients with mutation-positive lung and 15,158 controls. Four loci, 5p15.33 ( TERT ), 6p21.3 BTNL2 3q28 TP63 ) 17q24.2 BPTF previously shown to be strongly associated overall Asians, were...
Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical outcome, even early diagnosis; whereas high-grade serous carcinomas (SCs) endometrioid (ECs) are commonly chemosensitive at advanced stages. Although an integrated genomic analysis of SC has been performed, conclusive views on copy number expression profiles for CCC still limited. In this study, we performed single nucleotide polymorphism 57 epithelial ovarian cancers (31 CCCs, 14 SCs, 12 ECs)...
Hunner-type interstitial cystitis (HIC) is a rare, chronic inflammatory disease of the urinary bladder with unknown etiology and genetic background. Here, we conduct genome-wide association study 144 patients HIC 41,516 controls Japanese ancestry. The variant, rs1794275, in major histocompatibility complex (MHC) region (chromosome 6p21.3) associated risk (odds ratio [OR] = 2.32; p 3.4 × 10
The cellular origin of clear cell ovarian carcinoma (CCOC), a major histological subtype remains elusive. Here, we explored the candidate and identify molecular subtypes using integrated genomic/epigenomic analysis. We performed whole exome-sequencing, microarray, DNA methylation array in 78 CCOC samples according to original diagnosis. findings revealed that ARID1A and/or PIK3CA mutations were mutually exclusive with repair related genes, including TP53, BRCA1, ATM. Clustering other...
We describe 9 tumors that resemble soft tissue myoepitheliomas but possess certain traits do not fit perfectly into this category. These tumors, herein referred to as "myoepithelioma-like of the vulvar region," occurred in subcutis vulva and surrounding regions adult women aged 24 65 years. Histologically, measured 2 7.7 cm were well circumscribed, focally encapsulated, lobulated. Tumor cells had an epithelioid spindled shape, with fine amphophilic cytoplasm, uniform nuclei vesicular...