A5020358101- Statistical Methods in Clinical Trials
- Parvovirus B19 Infection Studies
- Optimal Experimental Design Methods
- Superconducting Materials and Applications
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Dermatological and COVID-19 studies
- Retinal and Macular Surgery
- Stroke Rehabilitation and Recovery
- Cancer Genomics and Diagnostics
- Cardiovascular Function and Risk Factors
- T-cell and Retrovirus Studies
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Intraocular Surgery and Lenses
- Esophageal and GI Pathology
- Animal Disease Management and Epidemiology
- Liver Disease Diagnosis and Treatment
- Particle accelerators and beam dynamics
- Computational Drug Discovery Methods
- Cardiac electrophysiology and arrhythmias
- Gastrointestinal disorders and treatments
Tokyo Medical and Dental University
2006-2025
Institute of Science Tokyo
2024-2025
Japan Atomic Energy Agency
2013-2025
Juntendo University
1983-2024
Tohoku University
1998-2024
The University of Tokyo
1994-2024
University of Tsukuba
2021-2024
Zero to Three
2024
University of Tampa
2024
Kyoto University
2001-2023
Abstract Iron as well aluminum is reported to accumulate in neurons with neurofibrillary tangles (NFTs) of Alzheimer's disease (AD) brain. Previously we demonstrated that (III) shows phosphate‐dependent binding hyperphosphorylated τ (PHFτ), the major constituent NFTs, thereby inducing aggregation PHFτ. Herein report iron can also induce soluble Importantly, for PHFτ occur, oxidized state essential since reduced (II) lacks such ability. Furthermore, (III)‐induced reversed by reducing (II)....
The authors wish to make a correction the above article that was published in J. Neurochem. 82, pp. 11371147 . following sentence appeared Materials and methods section on 1139 fifth paragraph: ‘The epitope tag referred as BE7 consists of seven amino acid residues sequence SEPYHHW, which is derived from VP2 protein human parvovirus B19. correct should read follows. SQPYHHW,
In oncology, next generation sequencing and comprehensive genomic profiling have enabled the detailed classification of tumors using molecular biology. However, it is unrealistic to conduct phase I-III trials according each sub-population based on patient subtypes. Common protocols that assess combination several markers their targeted therapies by means multiple sub-studies are required. These called "master protocols," drawing attention as a next-generation clinical trial design. Recently,...
ABSTRACT We recently reported the cloning and sequencing of the7 integrin chain its regulated expression during development skeletal muscle (Song et al. (1992)J. Cell Biol. 117, 643-657). The 7 is expressed myogenic lineage on adult fibers this suggests that it participates in multiple diverse functions at different times development. One interesting portion isoform cytoplasmic domain; comprised 77 amino acids largest alpha chains thus reported. In these experiments we begin to study...
Journal Article A Novel Acyl-CoA Synthetase, ACS5, Expressed in Intestinal Epithelial Cells and Proliferating Preadipocytes Get access Eisaku Oikawa, Oikawa *Tohoku University Gene Research Center, School of Medicine, Tohoku UniversitySendai 981-8555 Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroaki Iijima, Iijima Takashi Suzuki, Suzuki †Department Pathology, Hironobu Sasano, Sasano Hiroyuki Sato, Sato Akihisa Kamataki, Kamataki Hiroshi Nagura, Nagura...
ABSTRACT Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias. Here, we demonstrate that erythroblastoid UT7/Epo cells infected with virus fall into growth arrest 4N DNA, indicating G 2 /M arrest. These virus-infected displayed accumulation of cyclin A, B1, phosphorylated cdc2 were accompanied by an up-regulation in the kinase activity cdc2-cyclin B1 complex, similar to treated mitotic inhibitor. However,...
INTRODUCTION: Leucine-rich alpha-2 glycoprotein (LRG) is a newly studied biomarker for inflammatory diseases. This study aimed to investigate whether LRG can be used evaluating transmural activity in patients with Crohn's disease (CD). METHODS: We performed magnetic resonance enterography (MRE) 227 consecutive CD from June 2020 August 2021. prospectively compared MRE findings clinical and laboratory data including LRG. was evaluated using 2 validated scoring systems, inflammation defined as...
The purpose of this prospective randomized controlled trial was to assess the impact phase III comprehensive cardiac rehabilitation (CR) on health-related quality life (HRQOL) in elderly patients with coronary artery disease (CAD). Thirty-eight males (mean age, 70 years) CAD were stratified as intervention group (n=20) and control (n=18). In group, participated CR for 6 months, whereas they received standard care. Validated questionnaires obtained evaluate HRQOL using Medical Outcome Study...
Human parvovirus B19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. This cell damage is mediated by the viral nonstructural protein 1 (NS1) through an apoptotic mechanism. We previously demonstrated that virus infection induces G(2) arrest in UT7/Epo-S1 cells; however, role NS1 regulating cycle unknown. In this report, using paclitaxel, a mitotic inhibitor, we show not only but also G(1) arrest. Interestingly, UV-irradiated virus, which has...
Abstract The polymerase chain reaction (PCR) method was used to determine the presence and amount of human T lymphotropic virus type I (HTLV‐I) proviral DNA in central nervous system (CNS) tissue obtained at autopsy from 6 patients with HTLV‐I–associated myelopathy (HAM)/tropical spastic paraparesis (TSP), 1 patient adult T‐cell leukemia (ATL) CNS infiltration leukemic cells, 9 control subjects other neurological disorders. HTLV‐I pX env but not pol were detected 5 HAM/TSP. ATL samples...
Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used as drug for patients with acute inflammatory disorders such disseminated intravascular coagulation, shock, and pancreatitis in Japan. Recent studies have demonstrated that inhibitors may play an anti-inflammatory role beyond merely inhibitory action on neutrophil elastase at the site of inflammation least vitro. To clarify direct contributions UTI to condition vivo, we analyzed its roles experimental systemic...
We identified and mapped the regions responsible for neutralization in human parvovirus B19 structural protein by using region-specific antibodies derived from seropositive blood donors. The were purified affinity columns coupled with synthetic peptides of hydrophilic including beta-turn structure deduced predicted secondary VP2. Fifteen highly specific against obtained. Ten them able to precipitate radiolabeled virus. Six proved be protect colony-forming unit erythroid cells bone marrow...
Background Limited data are available regarding the effects of phase III cardiac rehabilitation on physical status and risk factors in elderly patients with coronary artery disease (CAD). Methods Results Thirty-four male CAD (>65 years old) were randomly assigned to an intervention group (n=18) or a control (n=16). The participated program consisting exercise training, diet therapy, weekly counseling for 6 months. In group, usual outpatient care was provided. body mass index, waist size fat...
[Figure: see text].
In this study, we identified a region in the human parvovirus structural protein which involves neutralization of virus by monoclonal antibody and site-specific synthetic peptides. A newly established reacted with both viral capsid proteins VP1 VP2. The epitope was found six strains independently isolated B19. could protect colony-forming unit erythroid bone marrow cell culture from injury virus. only 1 12 peptides that were synthesized according to predicted amino acid sequence based on...
BackgroundCardiac resynchronization therapy (CRT) is effective for patients with heart failure a QRS duration (QRSd) > 150 milliseconds (ms). However, its beneficial effect appears to be limited those "mid-range" QRSd (120–149 ms). Recent studies have demonstrated that modifying the left ventricular end-diastolic volume (LVEDV), modified QRSd, improves prediction of clinical outcomes CRT.ObjectiveTo investigate impact in regarding efficacy CRT.MethodsWe conducted retrospective, multi-center,...
The significance of resection para-aortic lymph node metastasis in colorectal cancer is controversial.