A5036276873- Cardiac Imaging and Diagnostics
- Fuel Cells and Related Materials
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Electrocatalysts for Energy Conversion
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- Conducting polymers and applications
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Acute Kidney Injury Research
- Advancements in Solid Oxide Fuel Cells
- Lymphatic System and Diseases
- Cardiac Fibrosis and Remodeling
- Renal and Vascular Pathologies
Kyushu University
2022-2024
Nippon Medical School
2015-2024
Japan Synchrotron Radiation Research Institute
2024
Nippon Medical School Hospital
2002-2023
Harbin Medical University
2014
Barro Colorado Island
2014
Second Affiliated Hospital of Harbin Medical University
2014
First Affiliated Hospital of Harbin Medical University
2014
St Thomas' Hospital
1994-1998
University of Dundee
1996
Thrombin can activate the plasma membrane Na + -H exchanger in a variety of noncardiac cells. We have studied (1) effect thrombin on activity sarcolemmal freshly isolated quiescent ventricular myocytes from adult rat heart and (2) signaling mechanism(s) underlying any effect. Reverse-transcription polymerase chain reaction analysis revealed receptor mRNA expression myocyte-enriched cell preparation. As an index activity, acid efflux rates ( J H s) were determined single (n=4 to 11 per group)...
We investigated efficacy and safety of implantation autologous bone marrow mononuclear cells plus platelets, including endothelial progenitor (EPCs), for recovering refractory chronic peripheral arterial disease (PAD) using visual quantitative analyses by 99m Tc-tetrofosmin (TF) perfusion scintigraphy, also various assessments objectively. performed 12 consecutive cases 19 limbs hands with severe PAD that were almost Fontaine class IV (11/12 cases, about 92%) in this trial. This treatment...
Activation of sarcolemmal Na+/H+ exchange has been proposed as a causal factor in reperfusion arrhythmogenesis. To test this hypothesis, we determined the antiarrhythmic efficacy two structurally distinct but equipotent Na+H+ inhibitors, 5-(N-ethyl-N-isopropyl)amiloride (EIPA) and novel drug, 3-methylsulfonyl-4-piperidinobenzoyl guanidine (HOE-694), isolated rat hearts (n = 12/group) subjected to independent dual coronary perfusion. After 15 min aerobic perfusion both beds, flow left bed...
Novel Ru-core Ir-shell catalyst-integrated porous transport electrodes (PTEs) for polymer electrolyte membrane water electrolysis (PEMWE) cells are prepared, in which catalyst nanostructures directly deposited onto a layer (PTL) via arc plasma deposition (APD). The PTL has nanostructured TiO2 surface prepared NaOH etching, acting as support. performance and durability of these catalysts depend strongly on the ratio Ir Ru. current-voltage (I–V) characteristics PEMWE were improved by applying...
Water activity recorded in asteroids offers a perspective on their habitability. Aqueous alteration, namely the interaction of liquid water with minerals, occurred parent body C-type asteroid Ryugu. However, Ryugu is not wet body, and processes that led to loss along its chemical environment remain unclear. We report presence sodium carbonates, chlorides sulfates samples, which indicate alkaline, salt-rich once flowed through body. Highly concentrated brine probably formed evaporation or...
Abstract —α 1 -Adrenoceptor (α -AR) stimulation increases sarcolemmal Na + -H exchanger (NHE) activity. The present study was designed to determine the role(s) of α -AR subtype(s) in mediating this response. As an index NHE activity, acid efflux rates ( J H s) were determined single rat ventricular myocytes loaded with pH-sensitive fluoroprobe carboxy-seminaphthorhodafluor-1 after 2 consecutive intracellular pulses bicarbonate-free medium. at pH i 6.90 did not change significantly during...
Stimulation of myocardial alpha 1 adrenoceptors causes (1) exacerbation reperfusion induced arrhythmias, and (2) stimulation sarcolemmal Na+/H+ exchange. The aims this study were to identify the adrenoceptor subtype involved in former effect determine whether exchanger may play a role phenomenon.Isolated rat hearts subjected independent perfusion left right coronary beds. After 15 min aerobic both beds, agonist phenylephrine (0.1, 1, or 10 microM) was infused selectively into bed for 2 min....
We examined the safety and efficacy of controlled-release basic fibroblast growth factor (b-FGF) for peripheral artery disease (PAD), compared with autologous bone marrow mononuclear cell implantation (BMCI).We recently developed a b-FGF-incorporated biodegradable hydrogel that enables slow-releasing drug delivery system.PAD patients were divided into b-FGF group (n=10) BMCI (n=15). Injection gelatin containing 600 μg or (0.4-5.1×10(10) cell) was performed. Visual analog pain scale (VAS),...
Unique Pt/TaOx/MC cathode electrocatalysts for polymer electrolyte fuel cells (PEFCs) are developed using partially-reduced TaOx decorated on mesoporous carbon (MC). An initial mass activity (MA) of more than 500 A g−1 was observed a TaOx/MC support heat treated at 700 °C in H2 or 1300 Ar, double that conventional Pt/C electrocatalyst. The durability against start-stop and load potential cycling successfully improved compared with the reference catalysts, as verified by half-cell voltammetry...
Abstract Aims Maintenance of euvolaemia with diuretics is critical in heart failure (HF) patients chronic kidney disease (CKD); however, it challenging because no reliable marker volume status exists. Fractional excretion urea nitrogen (FEUN) a useful index renal failure. We aimed to examine whether FEUN surrogate for risk stratification HF CKD. Methods and results examined 516 CKD (defined as discharge estimated glomerular filtration rate < 60 mL/min/1.73 m 2 ) whose was measured at...
Cardiac ruptures after myocardial infarction are classified as ventricular free wall (FWR), septal (VSR), and papillary muscle (PMR). A combination of any two types rupture is called "ventricular double rupture;" (VDR) shows a specific clinical course.3,284 patients with acute (AMI) were admitted to the CCU our hospital between April, 1973 December, 2001, 10 (8 males 2 female, aged 54∼82 years) VDR clinicopathologically evaluated. All diagnosed consisting FWR VSR. was observed in 0.30% all...
Although B-type natriuretic peptide (BNP) and highly sensitive cardiac troponin T (cTnT) are useful for the evaluation of clinical features in various cardiovascular diseases, there comparatively few data regarding utility these parameters patients with hypertrophic obstructive cardiomyopathy (HOCM). The goal this study was to assess association between BNP, cTnT HOCM.Cross-sectional surveyThe relationship end points echocardiographic investigated.This included 102 consecutive outpatients...
Reducing platinum group metal (PGM) loading and high current density operation are both essential for minimizing the capital expenditure (CAPEX) of polymer electrolyte membrane (PEM) electrolyzers. Catalyst-integrated porous transport electrodes (PTEs) in which iridium acts as a catalyst conductive coating on layer (PTL) surfaces, enable preparation Pt-coating-free PTLs, but can also result relatively activation ohmic overvoltages. Here, novel hybrid anode design combining an intermediate...
Myocardial bridge (MB) is a congenital anomaly of the coronary artery and may occur in 5 to 12% human population. However, mechanism MB-induced myocardial ischemia still speculative. We report 2 cases variant form angina pectoris associated with MB which seemed be related interaction between perfusion MB. In case 1, electrocardiography during anginal attack at rest showed ST elevation inferior leads was observed after percutaneous transluminal angioplasty site right lesion following...