A5101432038- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Photonic and Optical Devices
- Advanced Fiber Laser Technologies
- Cardiovascular Function and Risk Factors
- Semiconductor Lasers and Optical Devices
- Thermal Regulation in Medicine
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Laser-Matter Interactions and Applications
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Semiconductor Quantum Structures and Devices
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Colorectal Cancer Treatments and Studies
- Amino Acid Enzymes and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastrointestinal Tumor Research and Treatment
- Heart Rate Variability and Autonomic Control
- Cancer Treatment and Pharmacology
Fukushima Medical University
2025
Hyogo University
2023-2024
Fukuoka University
2023
Komaki City Hospital
2008-2022
Hyogo Medical University
2021-2022
Advanced Telecommunications Research Institute International
2022
National Cerebral and Cardiovascular Center
2012-2021
Tohoku University
2005-2020
Honda (Japan)
2018
Kagawa University Hospital
2017
Background— Previous animal and clinical studies suggest that bystander-initiated cardiac-only resuscitation may be superior to conventional cardiopulmonary (CPR) for out-of-hospital cardiac arrests. Our hypothesis was both bystander CPR would improve outcomes from arrests of ≤15 minutes’ duration, whereas the addition rescue breathing lasting >15 minutes. Methods Results— We carried out a prospective, population-based, observational study involving consecutive patients with emergency...
Background Carperitide is used to treat acute decompensated heart failure (ADHF), but its effects on long-term prognosis have not been studied. Methods and Results A multicenter randomized controlled study of 49 patients with ADHF was performed clarify the drug's prognosis. Low-dose carperitide (0.01-0.05 μg · kg-1 ·min-1) infused for 72h as initial treatment (n=26), whereas in control group (n=23), standard medical other than given without limitation. Anti-aldosterone drugs were prohibited...
Serine acetyltransferase (SATase; EC 2.3.1.30), which catalyzes the reaction connecting serine and cysteine/methionine metabolism, plays a regulatory role in cysteine biosynthesis plants. We have isolated cDNA clone encoding SATase by direct genetic complementation of Cys<sup>-</sup> mutation <i>Escherichia coli</i> using an expression library <i>Citrullus vulgaris</i> (watermelon) cDNA. The encodes polypeptide 294 amino acids (31,536 Da) exhibiting 51% homology with that <i>E. SATase....
Background:Adaptive servo-ventilation (ASV) therapy is expected to be novel nonpharmacotherapy with hemodynamic effects on patients chronic heart failure (CHF), but sufficient evidence has not been obtained.Methods and Results:A 24-week, open-label, randomized, controlled study was performed confirm the cardiac function-improving effect of ASV CHF patients. At 39 institutions, 213 outpatients CHF, whose left ventricular ejection fraction (LVEF) <40% who had mild severe symptoms [New York...
We demonstrate the terahertz-wave near-field imaging with subwavelength resolution using a bow-tie shaped aperture surrounded by concentric periodic structures in metal film. A grooves, which are known as bull’s eye structure, shows extremely large enhanced transmission beyond diffraction limit caused resonant excitation of surface waves. Additionally, exhibits extraordinary field enhancement at sharp tips metal, enhances and spatial resolution. introduced to structure achieved high (∼λ∕17)...
We have demonstrated successful two-photon excitation fluorescence bioimaging using a high-power pulsed all-semiconductor laser. Toward this purpose, we developed light source consisting of mode-locked laser diode and two-stage amplifier. This provided optical pulses 5 ps duration having maximum peak power over 100 W at wavelength 800 nm repetition frequency 500 MHz.
Mild hypothermia is an effective therapy for patients with return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest. However, evidence the effectiveness therapeutic (TH) remains unclear.A multicenter registry in Japan (J-PULSE-HYPO study registry) was conducted to investigate TH post-resuscitation neurological dysfunction developing arrest from 14 institutions, between January 2005 and December 2009. The committee entrusted each hospital timing cooling, cooling methods,...
Risk stratification of acute kidney injury (AKI) is important for decompensated heart failure (ADHF). The aim this study was to determine whether clinical markers, such as the blood urea nitrogen/creatinine ratio (BUN/Cr) or BUN creatinine values alone, stratify risk AKI mortality.In all, 371 consecutive ADHF patients were enrolled in study. defined serum ≥0.3 mg/dl a 1.5-fold increase levels within 48 h. During therapy, occurred 99 patients; 55 died during 12-month follow-up period....
The incidence of heart failure increases the subsequent risk ischemic stroke, and its could be higher in short-term period after an acute (AHF) event. However, determinants remain to clarified. Plasma D-dimer level reflects fibrin turnover exhibits unique properties as a biomarker thrombosis. aim this study is investigate whether determinant stroke patients with AHF.We examined 721 consecutive hospitalized AHF plasma on admission from our prospective registry between January 2013 May 2016....
Background:Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations placed emphasis the role of prehospital ECG, this technology is not widely used in Japan. We developed mobile telemedicine system (MTS) that continuously transmits real-time 12-lead from ambulances setting. This study was designed to compare...
Abstract —Activation of the sarcolemmal Na + -H exchanger (NHE) has been implicated as a mechanism inotropic, arrhythmogenic, antiacidotic, and hypertrophic effects α 1 -adrenoceptor (AR) stimulation. Although such regulation NHE activity shown to be selectively mediated through 1A -AR subtype, distal signaling mechanisms remain poorly defined. We investigated roles various kinase pathways in -AR–mediated stimulation adult rat ventricular myocytes. As an index activity, trans -sarcolemmal...
Background Despite evidence that pharmacological inhibition of the Na + /H exchanger (NHE) is cardioprotective, activation NHE has been proposed as a protective mechanism ischemic preconditioning (PC). Methods and Results In isolated rat ventricular myocytes (n=8 to 11 per group) loaded with fluorescent pH indicator C-SNARF-1, we showed HOE-642 (HOE) was potent inhibitor sarcolemmal (80% at 1 μmol/L); such readily reversible by washout drug. We confirmed μmol/L HOE produces significant...
Toward a practical light source for two-photon bioimaging, we have generated kilowatt peak power of 0.77 mum wavelength and 5 ps optical pulse via second-harmonic generation the amplified output from gain-switched 1.55 semiconductor laser. This compact scheme stable optical-pulse-source has been successfully used fluorescence bioimaging actin filaments in PtK2 cells.
Background: Although therapeutic hypothermia is an effective therapy for comatose adults experiencing out-of-hospital shockable cardiac arrest, there insufficient evidence that also applicable those with non-shockable arrest. Methods and Results: Of 452 treated after return of spontaneous circulation (ROSC) subsequent to arrest etiology, 372 who had a bystander-witnessed target core temperature 32–34°C cooling duration 12–72h were eligible this study (75 cases 297 arrest). The median...
Abstract —α 1 -Adrenoceptor (α -AR) stimulation increases sarcolemmal Na + -H exchanger (NHE) activity. The present study was designed to determine the role(s) of α -AR subtype(s) in mediating this response. As an index NHE activity, acid efflux rates ( J H s) were determined single rat ventricular myocytes loaded with pH-sensitive fluoroprobe carboxy-seminaphthorhodafluor-1 after 2 consecutive intracellular pulses bicarbonate-free medium. at pH i 6.90 did not change significantly during...
Yanai, Kazuhiko; Watanabe, Takehiko; Meguro, Kenichi; Yokoyama, Hiroyuki; Sato, Ikuro; Sasano, Hironobu; Itoh, Masatoshi; Iwata, Ren; Takahashi, Toshihiro; Ido, Tatsuo Author Information