A5061934624- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Cardiac Imaging and Diagnostics
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Mitochondrial Function and Pathology
- Acute Myocardial Infarction Research
- Synthesis and Reactivity of Heterocycles
- Pharmacological Effects of Natural Compounds
- Chemical synthesis and pharmacological studies
- Heart Rate Variability and Autonomic Control
- Stroke Rehabilitation and Recovery
- Synthesis of heterocyclic compounds
- Signaling Pathways in Disease
- Renin-Angiotensin System Studies
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
National Cerebral and Cardiovascular Center
2014-2023
Impact
2016
Cardiovascular Research Center
2010
Kyoto University
2001-2009
Gifu University
2009
Jichi Medical University
2009
Kyoto College of Medical Science
2006-2007
Nakanishi (Japan)
2002-2007
Howard Hughes Medical Institute
2002-2005
Institute of Applied Biochemistry
2002-2005
MicroRNAs (miRNAs) are endogenous small RNAs 21-25 nucleotides in length. Recently, we reported that miRNA 208 (miR-208) is produced exclusively the rat myocardium and plasma miR-208 a biomarker of myocardial injury rats. In present study, assessed hypothesis concentrations myocardial-specific miRNAs can be used to diagnose humans.We array analysis production various human tissues identify heart-specific miRNAs. We miR-499 14 individuals with acute coronary syndromes, 15 congestive heart...
PAD peripheral arterial disease PCI percutaneous coronary intervention peak V ˙O2 oxygen uptake PH pulmonary hypertension PVCs premature ventricular contraction QOL quality of life RCT randomized controlled trial RPE rating perceived exertion SGA Subjective Global Assessment STEMI ST elevation myocardial infarction TG triglyceride TAVI transcatheter aortic valve implantation VAD assist device ˙CO2 carbon dioxide output ˙E minute ventilation ˙E/V ventilatory equivalent for vs. slope ˙O2/HR...
MicroRNAs (miRNAs) are endogenous small RNAs that 21-25 nucleotides in length. Recently, plasma miRNAs have been reported to be sensitive and specific biomarkers of various tissue injuries pathological conditions. The goal this study was assess miRNA profiles identify differentially expressed patients with heart failure.A total 33 ischemic diseases 17 asymptomatic controls were recruited. In 10 failure, assessed at both NYHA IV III. array analyses found not appropriate for profiling....
There are limited data about the optimal anti-thrombotic therapy for preventing embolism while minimizing bleeding events in patients with first acute myocardial infarction (AMI) complicated by left ventricular thrombus (LVT). Among 2301 consecutive AMI hospitalized between 2001 and 2014, we studied 1850 who discharged alive to investigate clinical characteristics, incidence of systemic (SE), association anticoagulation embolic or events. Left was diagnosed echocardiography,...
MicroRNAs (miRNAs) are endogenous small RNAs that 18–23 nucleotides long. Recently, plasma miRNAs were reported to be sensitive and specific biomarkers of various pathological conditions. In the present study, we focused on miR-210, which is known induced by hypoxia might therefore an excellent biomarker for congestive heart failure. Plasma miR-210 levels expression in mononuclear cells skeletal muscles elevated Dahl salt-sensitive rats with We also assessed patients The NYHA III IV failure...
Although there are regional reports that the COVID-19 pandemic is associated with a reduction in acute myocardial infarction presentations and primary percutaneous coronary intervention (PCI) procedures, little known about impact of on mechanical complications resulting from ST-segment elevation (STEMI) mortality.This single-centre retrospective cohort study analysed presentations, incidence complications, mortality patients STEMI before after state emergency was declared due to by Japanese...
Induction of the atrial natriuretic peptide (ANP) gene is a common feature ventricular hypertrophy. A number cis-acting enhancer elements for several transcriptional activators have been shown to play central roles in regulation ANP expression, but much less known about contributions made by repressors. The neuron-restrictive silencer element (NRSE), also as repressor 1, mediates repression neuronal expression nonneuronal cells. We found that NRSE, which located 3′ untranslated region gene,...
Recent clinical trials have shown that systemic infusion of nesiritide, a recombinant human brain natriuretic peptide (BNP), improves hemodynamic parameters in acutely decompensated hearts. This suggests BNP exerts direct cardioprotective effect and might thus be useful therapeutic agent with which to treat acute myocardial infarction (MI). In the present study, we used BNP-transgenic (BNP-Tg) mice elevated plasma determine whether how contributes left ventricular remodeling healing after...
Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression T-type Ca(2+) channels contributes to the progression failure. The ability channel blockade prevent lethal arrhythmias associated has never been tested, however.We compared effects efonidipine and mibefradil, dual T- L-type blockers, those nitrendipine, a selective blocker, on survival arrhythmogenicity...
Background: Acute kidney injury (AKI) and acute hyperglycemia are associated with unfavorable outcomes. The impact of on the development AKI after myocardial infarction (AMI), however, remains unclear. This study was undertaken to assess relationship between admission glucose incidence AMI. Methods Results: consisted 760 patients AMI admitted National Cerebral Cardiovascular Center within 48h symptom onset. Blood sample obtained repeated sampling done at least every 1 or 2 days during first...
Background:Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations placed emphasis the role of prehospital ECG, this technology is not widely used in Japan. We developed mobile telemedicine system (MTS) that continuously transmits real-time 12-lead from ambulances setting. This study was designed to compare...
<h3>Objective</h3> To determine safety and efficacy of cardiac rehabilitation (CR) initiated immediately following balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic hypertension (CTEPH) who presented continuing exercise intolerance symptoms on effort even after a course BPA; 2–8 sessions/patient. <h3>Methods</h3> Forty-one consecutive CTEPH underwent their final BPA improved resting mean arterial pressure 24.7±5.5 mm Hg suffered remaining were...
Guanylyl cyclase (GC)-A, a natriuretic peptide receptor, lowers blood pressure and inhibits the growth of cardiac myocytes fibroblasts. Angiotensin II (Ang II) type 1A (AT1A), an Ang regulates cardiovascular homeostasis oppositely. Disruption GC-A induces hypertrophy fibrosis, suggesting that protects heart from abnormal remodeling. We investigated whether interacts with AT1A signaling in by target deletion pharmacological blockade or stimulation mice.We generated double-knockout (KO) mice...
Angiotensin II plays a prominent role in the progression of heart failure after acute myocardial infarction (AMI). Although both angiotensin type 1 (AT1) and 2 (AT2) receptors are known to be present heart, comparatively little is about latter. We therefore examined played by AT2 post-AMI failure.In wild-type mice subjected AMI coronary artery ligation, receptor immunoreactivity upregulated infarct border areas. Among receptor-null (-/-) mice, 7-day survival rate was significantly lower than...
Abstract Myocardial hypertrophy and extended cardiac fibrosis are independent risk factors for congestive heart failure sudden death. Before age 50, men at greater cardiovascular disease than age-matched women. In the current studies, we found that were significantly more pronounced in males compared with females of guanylyl cyclase-A knockout (GC-A KO) mice 16 wk age. These gender-related differences not seen wild-type mice. further either castration (at 10 age) or flutamide, an androgen...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPsychotropic drugs. 18. Synthesis and structure-activity relations of 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-onesMichio Nakanishi, Tetsuya Tahara, Kazuhiko Araki, Masami Shiroki, Tatsumi Tsumagari, Yukio TakigawaCite this: J. Med. Chem. 1973, 16, 3, 214–219Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://doi.org/10.1021/jm00261a010RIGHTS & PERMISSIONSArticle...
Although there is a general fear that exercise training might deteriorate renal function in chronic kidney disease (CKD) patients, the effect of cardiac rehabilitation (CR) on acute myocardial infarction (AMI) patients with CKD remains unknown. We sought to determine whether CR associated amelioration or deterioration such patients.We enrolled 528 AMI who participated 3-month program. Clinical data before and after were compared according participation comorbidities. In without (estimated...
Ghrelin is a GH-releasing peptide mainly excreted from the stomach. administration has been shown to inhibit cardiac sympathetic nerve activity (CSNA), reduce malignant arrhythmia, and improve prognosis after acute myocardial infarction (MI). We therefore investigated effects potential mechanisms of action endogenous ghrelin on survival rate CSNA MI by using ghrelin-knockout (KO) mice. was induced left coronary artery ligation in 46 KO mice 41 wild-type On first day, arrhythmia-induced...
Although plasma levels of atrial natriuretic peptide (ANP) and brain (BNP) are elevated early after myocardial infarction (MI), the significance is not fully understood. We therefore investigated function peptides induction MI in knockout (KO) mice lacking receptor guanylyl cyclase-A, for ANP BNP. KO wild-type (WT) were subjected to left coronary artery ligation then followed up 4 weeks. Irrespective genotype, almost all deaths occurred within 1 week MI. showed significantly higher mortality...