A5062218013- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Nerve injury and regeneration
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Infective Endocarditis Diagnosis and Management
- Medical Imaging Techniques and Applications
- Particle Detector Development and Performance
- Blood transfusion and management
- Obstructive Sleep Apnea Research
- Metallic Glasses and Amorphous Alloys
- Magnetic Properties and Applications
- Radiation Detection and Scintillator Technologies
Hamamatsu University School of Medicine
2019-2024
Ehime University
2023
Showa University Northern Yokohama Hospital
2023
Leiden University Medical Center
2017-2021
Meiji University of Integrative Medicine
2009-2021
Gifu University
2021
University of Tsukuba
2010-2020
Ibaraki Prefectural Central Hospital
2011-2020
Yokohama Rosai Hospital
2012-2019
Tsukuba Medical Center Hospital
2012-2014
Accumulative evidence suggests that more than 20 neuron-specific genes are regulated by a transcriptional cis-regulatory element known as the neural restrictive silencer (NRS). A trans-acting repressor binds NRS, NRSF [also designated RE1-silencing transcription factor (REST)] has been cloned, but mechanism which it represses is unknown. Here we show of its target recruiting mSin3 and histone deacetylase. Transfection experiments using series deletion constructs revealed presence two...
Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and deacetylases (HDACs) commonly implicated in regulation gene transcription. However, little is known about transcriptional mammalian modification. Here, we show that state acetylated histones fluctuated parallel with rhythm mouse Per1 (mPer1) or mPer2 expression fibroblast cells liver. Mouse CRY1 (mCRY1) repressed transcription...
Background— Recent evidence has linked early repolarization (ER) to idiopathic ventricular fibrillation (VF) in patients without structural heart disease. However, no studies have clarified whether or not there is an association between ER and the VF occurrences after onset of acute myocardial infarction (AMI). Methods Results— This study retrospectively included 220 consecutive with AMI (57 female; mean age, 69 ± 11 years) whom 12-lead ECGs before could be evaluated. The were classified on...
Fatal arrhythmia is commonly observed in cardiac sarcoidosis, but clinical effects of a systematic treatment approach are still uncertain. This study sought to describe both and electrophysiological characteristics outcomes ventricular tachycardia (VT) associated with sarcoidosis.
Abstract Aims This study evaluated the prognosis and prognostic factors of patients with cardiac sarcoidosis (CS), an underdiagnosed disease. Methods results Patients from a retrospective multicentre registry, diagnosed CS between 2001 2017 based on 2016 Japanese Circulation Society or 2014 Heart Rhythm criteria, were included. The primary endpoint was composite all-cause death, hospitalization for heart failure, documented fatal ventricular arrhythmia events (FVAE), each constituting...
Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and relation LGE findings in patients with Takotsubo cardiomyopathy (TTC). We evaluated 20 consecutive (2 men, 18 women; median age, 77 years; interquartile range [IQR] 67-82 years) who were admitted our hospital diagnosis TTC. CMR was performed within 1 week after admission, follow-up studies conducted 1.5 6 months later. In 8 patients, imaging during...
Induction of the atrial natriuretic peptide (ANP) gene is a common feature ventricular hypertrophy. A number cis-acting enhancer elements for several transcriptional activators have been shown to play central roles in regulation ANP expression, but much less known about contributions made by repressors. The neuron-restrictive silencer element (NRSE), also as repressor 1, mediates repression neuronal expression nonneuronal cells. We found that NRSE, which located 3′ untranslated region gene,...
Abstract Aims Although the delivery catheter system for pacemaker-lead implantation is a new alternative to stylet system, no randomized controlled trial has addressed difference in right ventricular (RV) lead placement accuracy septum between and systems. This multicentre prospective aimed prove efficacy of accurate RV septum. Methods results In this trial, 70 patients (mean age 78 ± 11 years; 30 men) with pacemaker indications atrioventricular block were or groups. Right tip positions...
Owing to the paucity of data, this study aimed investigate sex differences in clinical features and prognosis patients with cardiac sarcoidosis (CS).This was a secondary analysis ILLUstration Management prognosIs JapaNese PATiEnts Cardiac Sarcoidosis registry-a retrospective multicentre registry that enrolled CS between 2001 2017. The primary outcome potentially fatal ventricular arrhythmia events (pFVAEs)-a composite sudden death, sustained tachycardia lasting >30 s, fibrillation or...
Objectives Diagnosis of cardiac sarcoidosis (CS) without histological evidence remains controversial. This study aimed to compare characteristics and outcomes histologically proven versus clinically diagnosed cases CS, which were adjudicated using Heart Rhythm Society or Japanese Circulation criteria. Methods A total 512 patients with CS (age: 62±11 years, female: 64.3%) enrolled in the multicentre registry studied. Histologically confirmed classified as ‘biopsy-proven CS’, while those...
Current guidelines recommend placing an implantable cardiac defibrillator for patients with sarcoidosis and a severely impaired left ventricular ejection fraction (LVEF) of ≤35%. In this study, we determined the association between mild or moderate LVEF impairment fatal arrhythmic event (FVAE).
Background— We recently showed that the presence of early repolarization (ER) increases risk ventricular fibrillation occurrences in phase acute myocardial infarction (AMI). This study aimed to clarify whether an association exists between ER and tachyarrhythmias or sudden death chronic AMI. Methods Results— retrospectively enrolled 1131 patients (67±12 years; 862 men) with AMIs surviving 14 days post-AMI. The primary end point was occurrence sustained >14 after AMI onset. evaluated from...
Ventricular arrhythmia (VA) is a life-threatening condition associated with cardiac sarcoidosis (CS). Right bundle branch block (RBBB) common conduction disorder in CS; however, its association VA remains unknown.