A5086772095- Semiconductor materials and devices
- Magnetic confinement fusion research
- Silicon and Solar Cell Technologies
- Astrophysics and Cosmic Phenomena
- Semiconductor Quantum Structures and Devices
- Copper Interconnects and Reliability
- Dark Matter and Cosmic Phenomena
- Semiconductor materials and interfaces
- Silicon Nanostructures and Photoluminescence
- Ionosphere and magnetosphere dynamics
- Advanced Semiconductor Detectors and Materials
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Particle accelerators and beam dynamics
- Neutrino Physics Research
- Thin-Film Transistor Technologies
- Cardiac pacing and defibrillation studies
- Superconducting Materials and Applications
- Semiconductor Lasers and Optical Devices
- Solidification and crystal growth phenomena
- Solar and Space Plasma Dynamics
- Thyroid Disorders and Treatments
- 3D IC and TSV technologies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
Nagoya University
2003-2025
Osaka University
2015-2025
Mie Chuo Medical Center
2023-2025
Osaka University Hospital
2015-2024
Saitama University
1992-2024
Mie University Hospital
2024
GTx (United States)
2023
Kumamoto University
2023
Mie University
2023
Kansai Electric Power Hospital
2012-2022
Background: T helper type 1 (Th1), Th2, and Th17 cells produce interferon (IFN)-γ, interleukin (IL)-4, IL-17A, respectively. We reported that IFN-γ IL-4 gene polymorphisms, which are related to higher lower production, respectively, more frequent in patients with severe Hashimoto's disease (HD) than those mild HD. now aim investigate the proportion of peripheral Th1, autoimmune thyroid (AITD). Methods: studied 17 HD who developed hypothyroidism were treated l-thyroxine, referred as HD;...
Abstract Background The diagnosis of ischemic non-obstructive coronary artery disease is crucial for the differential chest pain. However, pathophysiology pain and evaluation microcirculation in patients with right ventricular pacing (RVP) have not been sufficiently reported. Case Summary patient was a 53-year-old woman who underwent dual-chamber pacemaker implantation because sinus node dysfunction. She experienced before implantation; however, frequency severity her increased after...
Summary The severity of Hashimoto's disease (HD) and intractability (or inducibility to remission) Graves' (GD) varies among patients. Forkhead box P3 (FoxP3) is a crucial regulatory factor for the development function T (Treg) cells, deficiency FoxP3 gene (FOXP3) suppresses Treg cells. To clarify association functional polymorphisms FOXP3 with prognosis GD HD, we genotyped −3499A/G, −3279C/A −2383C/T in obtained from 38 patients severe 40 mild 65 intractable GD, whom remission was difficult...
Vascular endothelium, which produces endothelium-derived relaxing and constricting factors, plays an important role in regulating the vascular tone. We recently demonstrated that oxidized low density lipoprotein inhibited endothelium-dependent relaxation lysophosphatidylcholine accumulated during oxidative modification of was essential substance for inhibition relaxation. To clarify mechanisms inhibitory effect lysophosphatidylcholine, we used a bioassay system to investigate on production...
A reliable conversion factor for the infrared absorptiometry of oxygen in silicon has been determined by round‐robin measurement followed charged particle activation analysis with reaction. As samples, 70 dislocation‐free CZ wafers contents ranging from and thicknesses 2, 1, 0.5 mm were carefully prepared five organizations. good linear relationship obtained between absorption coefficient content. The is expressed as .
Summary To clarify the association between factors regulating DNA methylation and prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) methionine synthase (MTRR), which are enzymes essential for methylation. Subjects this study included 125 patients with Hashimoto's disease (HD), including 48 severe HD 49 mild HD; 176 Graves’ (GD), 79...
N+ implantation into p-type α-SiC (6H-SiC, 4H-SiC) epilayers at room and elevated temperatures, mainly obtained by the authors' group, has been reviewed. Since recrystallization of SiC is difficult, implantation-induced damage should be minimal during to achieve higher electrical activation. The effects hot are pronounced in high-dose (>1015 cm—2) implantation. lowest sheet resistance 542 Ω/□ was 500 800 °C with a 4 × 1015cm—2 dose. properties pn junctions formed characterized detail....
Summary Interleukin (IL)-1β is a proinflammatory cytokine and has been implicated in the pathogenesis of several autoimmune diseases. To evaluate hypothesis that functional −31C/T polymorphism (rs1143627) gene encoding IL-1β associated with intractability severity thyroid diseases, we genotyped this 64 patients intractable Graves' disease (GD), 28 GD remission, 49 Hashimoto's (HD) who developed hypothyroidism (severe HD), untreated euthyroid HD (mild HD) 59 healthy volunteers. The −31T...
Vitamin D is a multi-functional immune regulator, and low serum concentration of vitamin promotes autoimmune inflammation. In this study, we evaluate the association between prognosis thyroid disease (AITD) functional polymorphisms genes that regulate metabolism. For 139 Graves' (GD) patients, 116 Hashimoto's (HD) patients 76 control subjects, genotyped following using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP): receptor (VDR): rs731236, rs7975232,...
Abstract Aims Although the delivery catheter system for pacemaker-lead implantation is a new alternative to stylet system, no randomized controlled trial has addressed difference in right ventricular (RV) lead placement accuracy septum between and systems. This multicentre prospective aimed prove efficacy of accurate RV septum. Methods results In this trial, 70 patients (mean age 78 ± 11 years; 30 men) with pacemaker indications atrioventricular block were or groups. Right tip positions...
Optimization studies have been done for the helical axis heliotron configuration. One purpose is to find a configuration suitable experimental of basic properties heliotron. In present study, role bumpy field component (toroidal mirror ratio) in MHD stability and neoclassical confinement this type examined. The physical mechanism improvement transport through control clarified. physics design current status new device, Heliotron J, are also described.
To clarify the association of genetic producibility interleukin (IL)-5, IL-6 and IL-13, which are secreted by T helper type 2 (Th2), with development prognosis autoimmune thyroid disease (AITD), we genotyped IL5-746C/T, IL6-572C/G IL13-1112C/T polymorphisms, functional polymorphisms in promoter regions genes regulating these cytokines. Fifty-seven patients intractable Graves' (GD), 52 GD remission, severe Hashimoto's (HD), 56 mild HD 91 healthy controls were examined this study. The...
It is important to search the biomarker predict development and prognosis of autoimmune thyroid diseases (AITDs) such as Hashimoto's disease (HD) Graves' (GD). MicroRNA (miR) bind directly 3' untranslated region specific target mRNAs suppress expression proteins, promote degradation regulate immune response. miR-125a known be a negative regulator regulated upon activation normal T cell expressed secreted (RANTES), interleukin (IL)-6 transforming growth factor (TGF)-β; however, its...
The measurement of the energy spectrum ultra-high-energy cosmic rays (UHECRs) is crucial importance to clarify their origin and acceleration mechanisms. Pierre Auger Observatory in Argentina Telescope Array (TA) US have reported measurements UHECR spectra observed southern northern hemisphere, respectively. region sky accessible both Observatories ($[-15,+24]$ degrees declination) can be used cross-calibrate two spectra. Auger-TA working group was organized 2012 has been understand...
Immune-inflammatory processes are highly associated with the progression of atherosclerosis. The systemic immune-inflammation index (SII) is a potential predictor for clinical outcomes in patients stroke and ischemic heart disease. Therefore, this study aimed to investigate whether SII can accurately predict short- long-term prognoses who underwent carotid artery stenting (CAS) compared that C-reactive protein (CRP).This was single-center retrospective investigation. Overall, 129 CAS were...
MicroRNA (miRNA) is a family of non-coding RNAs that have important roles in various vital functions. It has been reported let-7e, miRNA, may be involved the regulation interleukin (IL)-10 production. The purpose this study was to evaluate role let-7e as regulator IL-10 production pathological processes autoimmune thyroid diseases (AITDs). We evaluated association between expression and intracellular peripheral blood mononuclear cells (PBMCs) collected from 11 healthy volunteers. Then we...
Regulatory T (Treg) cells, which play an important role in maintaining self-tolerance, are present the thyroid-infiltrating lymphocytes of patients with autoimmune thyroid disease (AITD). We examined expression membrane-bound transforming growth factor-β1 (mTGF-β1), mediates regulatory function and glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). The turn may inhibit on Treg cells TGF-β1 receptor II (TGF-βRII) GITR expression. also evaluated ligand (GITRL)...