A5043965300- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Viral-associated cancers and disorders
- Liver Diseases and Immunity
- Hepatitis C virus research
- Pancreatic function and diabetes
- Colorectal Cancer Surgical Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
Kyoto University
2016-2025
Kitano Hospital
2022-2025
Kyoto University Hospital
2006-2022
Pancreas Centre (Canada)
2022
East Asia School of Theology
2022
Center for Digestive and Liver Diseases
2022
The Japanese Society of Gastroenterological Surgery
2016
Graduate School USA
2015
Northwestern University
2014
Centre de Recherche sur l'Inflammation
2014
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) Kupffer cells, two key cell types in fibrogenesis. Here, we investigate role CCR2, receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, MCP-3, fibrosis. Hepatic MCP-1, MCP-3 messenger RNA expression was increased after bile duct ligation (BDL). Both HSCs, but not hepatocytes, expressed CCR2. BDL- CCl(4)-induced fibrosis markedly reduced CCR2(-/-) mice as assessed through collagen...
The origin of fibrogenic cells in liver fibrosis remains controversial. We assessed the emerging concept that hepatocytes contribute to production extracellular matrix (ECM) through epithelial-mesenchymal transition (EMT). bred triple transgenic mice expressing ROSA26 stop β-galactosidase (β-gal), albumin Cre, and collagen α1(I) green fluorescent protein (GFP), which hepatocyte-derived are permanently labeled by β-gal type I collagen-expressing GFP. induced repetitive carbon tetrachloride...
Chronic hepatitis C is characterized by iron accumulation in the liver, and excessive hepatotoxic. However, mechanism which virus (HCV) regulates metabolism poorly understood. Hepcidin plays a pivotal role as negative regulator of absorption. The aim current study was to elucidate mechanisms that govern hepcidin expression HCV. Huh 7 cells, Huh7.5 full-length HCV replicon cells established from adenoviruses expressing HCV-core or nonstructural proteins 3 through 5 (NS3-5) were used....
CCAAT/enhancer-binding protein (C/EBP) homologous (CHOP) is a key component in endoplasmic reticulum (ER) stress-mediated apoptosis. The goal of the study was to investigate role CHOP cholestatic liver injury. Acute injury and fibrosis were assessed wild-type (WT) CHOP-deficient mice following bile duct ligation (BDL). In WT livers, BDL induced overexpression Bax, downstream target CHOP-mediated ER stress pathway. Liver attenuated CHOP-knockout mice. Expression levels alpha-smooth muscle...
Objective: To evaluate preoperative body composition, including skeletal muscle and visceral adipose tissue, to clarify the impact on outcomes after hepatectomy for hepatocellular carcinoma (HCC). Background: Recent studies have indicated that sarcopenia is associated with morbidity mortality in various pathologies, cancer, obesity or adiposity represents a significant risk factor several cancers. However, of sarcopenic HCC has not been fully investigated. Methods: We retrospectively...
Excessive acetaminophen (APAP) use is one of the most common causes acute liver failure. Various types cell death in damaged are linked to APAP-induced hepatotoxicity, and, these, necrotic hepatocytes has been shown be involved disease pathogenesis. Until recently, necrosis was commonly considered a random and unregulated form death; however, recent studies have identified previously unknown programmed called receptor-interacting protein kinase (RIPK)-dependent (or necroptosis), which...
Peroxisome proliferator-activated receptor delta (PPARδ), a member of the nuclear family, is emerging as key metabolic regulator with pleiotropic actions on various tissues including fat, skeletal muscle, and liver. Here we show that PPARδ agonist KD3010, but not well-validated GW501516, dramatically ameliorates liver injury induced by carbon tetrachloride (CCl 4 ) injections. Deposition extracellular matrix proteins was lower in KD3010-treated group than vehicle- or GW501516-treated group....
Objective: The aim of the present study was to evaluate usefulness a new imaging device, Medical Imaging Projection System (MIPS), which uses indocyanine green emission signal and active projection mapping, for liver resection. Background: During anatomic resection, surgeons cannot completely view intraparenchymal structure. Although fluorescent technique using has recently been developed hepatobiliary surgery, limitations in its application real-time navigation persist. Methods: We...
Most chronic liver diseases of all etiologies result in progressive fibrosis. Myofibroblasts produce the extracellular matrix, including type I collagen, which constitutes fibrous scar Normal has little collagen and no detectable myofibroblasts, but myofibroblasts appear early experimental clinical injury. The origin myofibroblast fibrosis is still unresolved. possibilities include activation endogenous mesenchymal cells fibroblasts hepatic stellate cells, recruitment from bone marrow,...
Visceral adiposity, defined as a high visceral-to-subcutaneous adipose tissue area ratio (VSR), has been shown to be associated with poor outcomes in several cancers. However, the surgical field, significance of visceral adiposity remains controversial. The present study investigated impact well sarcopenic factors (low muscularity) on patients undergoing hepatectomy for hepatocellular carcinoma (HCC).This retrospective analyzed data from 606 HCC at our institution between April 2005 and...
Cholestatic liver fibrosis is caused by obstruction of the biliary tract and associated with early activation portal fibroblasts (PFs) that express Thy-1, fibulin 2, recently identified marker mesothelin (MSLN). Here, we have demonstrated activated PFs (aPFs) myofibroblasts play a critical role in pathogenesis induced bile duct ligation (BDL). Conditional ablation MSLN+ aPFs BDL-injured mice attenuated approximately 50%. Similar results were observed MSLN-deficient (Msln-/- mice) or...
Objective: To evaluate the long-term outcomes of surgery for recurrent hepatocellular carcinoma (HCC). Background: HCC recurs with high incidence after liver resection. Little is known about patients undergoing HCC. Methods: Among 989 who underwent R0/R1 resection between 1995 and 2014, 676 exhibited recurrence were included. Repeat was performed in 128 (RS group), not remaining 548 (NS group). Prognostic value repeat evaluated by comparing survival (SAR) RS NS groups. Subgroup analyses...
Although modifications of gut microbiota with antibiotics (Abx) influence mouse skin and cardiac allografts, its role in orthotopic liver transplantation (OLT) remains unknown. We aimed to determine whether how recipient Abx pretreatment may affect hepatic ischemia-reperfusion injury (IRI) OLT outcomes. Mice (C57BL/6) or without treatment (10 days) were transplanted allogeneic (BALB/c) cold-stored (18 hours) livers, followed by blood sampling (6 hours). divided 264 human recipients on the...
By comparing cohorts in 2 exclusive time frames, the factors that affected surgical outcomes of patients with hepatocellular carcinoma (HCC) are presented.Reportedly, survival results HCC who underwent hepatectomy have improved recent years. However, major contributing to these favorable not been fully explained.Between January 1985 and December 2000, 610 liver resections as a primary curative resection. They were categorized into groups according year which surgeries performed: before 1990...
The renin-angiotensin system (RAS) plays a major role in liver fibrosis. Recently, homolog of angiotensin-converting-enzyme 1 (ACE1), termed ACE2, has been identified that appears to be negative regulator the RAS by degrading Ang II Ang(1-7). aim this study was characterize long-term effects gene deletion ACE2 liver, define acute and chronic disease, Ang(1-7) hepatic stellate cell (HSC) activation. Ace2 knockout (KO) mice wild-type (wt) littermates underwent different models injury. Liver...