A5004009208- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Congenital Anomalies and Fetal Surgery
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- IgG4-Related and Inflammatory Diseases
- Biliary and Gastrointestinal Fistulas
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Inflammatory Bowel Disease
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Lymphoma Diagnosis and Treatment
- Diverticular Disease and Complications
Kitano Hospital
2016-2025
Kyoto University
2001-2010
Kyoto University Hospital
2009
In-Q-Tel
2008
Hy-Line (United States)
2006
Kobe City Medical Center General Hospital
2005
Kobe University
2002
YKK (Japan)
2000
The requirements of biliary stents used in the palliation malignant obstruction are a long duration patency and minimal adverse effects. Covered self-expandable metal (SEMSs) have been shown to prevent tumor ingrowth, which is most frequent complication uncovered SEMSs. However, because they prone migration, superiority covered SEMS has yet be convincingly demonstrated. aim this study was evaluate over SEMSs distal due unresectable pancreatic carcinoma, using both stent types with relatively...
Objective: Autoimmune pancreatitis (AIP) is a new clinical entity of pancreatic disorder. There are several immunologic and histological abnormalities specific for the disease, including increased levels serum IgG4 infiltration lymphocytes IgG4-positive plasmacytes. The role unclear. Recently, regulatory T cells (Tregs) have been reported to be involved in development various autoimmune diseases as well B cell shifting IgG4-producing To clarify Tregs pathophysiology AIP, we analyzed...
<b>Background and study aims: </b>Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with 25-gauge needles yields small volume samples that are mainly processed for cytology. Using a core trap may overcome this limitation. This trial compared without in terms of their ability to obtain histologic from solid pancreatic masses. <b>Patients methods: </b>Consecutive patients masses who presented eight Japanese referral centers EUS-FNA April – September 2013 were randomized undergo...
Background. The aims of this study were to characterize the features biliary strictures that occur after duct-to-duct reconstruction during right-lobe living-donor liver transplantation (LDLT) and evaluate feasibility correcting such stricture endoscopically by inserting an "inside stent," is, a short internal stent, above sphincter Oddi. Methods. Biliary occurred in 26 (35.6%) 73 consecutive patients who underwent LDLT with from July 1999 through October 2001 survived for more than 3...
Although the advent of ultra-deep sequencing technology allows for analysis heretofore-undetectable minor viral mutants, a limited amount information is currently available regarding clinical implications hepatitis B virus (HBV) genomic heterogeneity.To characterize HBV genetic heterogeneity in association with anti-viral therapy, we performed full-genome liver and serum 19 patients chronic infection, including 14 therapy-naïve 5 nucleos(t)ide analogue(NA)-treated cases.Most changes observed...
The reported incidence of adverse events (AEs) in endoscopic retrograde cholangiopancreatography (ERCP) varies between 2.5% and 14%. aim this study was to evaluate the severity AEs biliary ERCP specify risk factors preventive measures for post-ERCP pancreatitis (PEP).Patients with disease intact papilla were prospectively enrolled at 36 hospitals April 2017 March 2018. primary outcomes AEs.A total 16,032 procedures performed during period 3739 patients enrolled. overall 10.1% ERCP-related...
Breast cancer is one of the most common malignancies among women. The molecular mechanisms involved in breast carcinogenesis, however, remain to be elucidated. Although somatic mutation BRCA1 rare, protein expression reduced about 30% sporadic carcinomas (Yoshikawa et al., Clin. Cancer Res., 5:1249–1261, 1999), indicating its possible involvement even carcinogenesis. Among BRCA1-interactive proteins are hRAD51 (a human homologue Escherichia coli rec A protein), BARD1 (BRCA1-associated RING...
Abstract Our previous studies suggest that lack of RUNX3 function is causally related to the genesis and progression human gastric cancer, but potential roles other members RUNX family genes have not yet been reported. We examined expression 3 Runt‐related (RUNX) genes, RUNX1, RUNX2 CBFB , in cancer cell lines primary specimens compared them those reported earlier conjunction with clinicopathologic factors. Expression 9 lines, 56 surrounding normal mucosa were estimated by Northern blot...
Abstract Purpose: Our previous results suggested that a lack of RUNX3 function contributed to human gastric carcinogenesis, but the role in progression and metastasis remains unclear. We examined expression clinical samples peritoneal metastases cancers. Changes metastatic potential were assessed animal experiments using stable transfectants cancer cells. Finally, global changes analyzed cDNA microarray. Experimental Design Results: Significant down-regulation through methylation on promoter...
It remains unclear whether lymphoma of the mucosa-associated lymphoid tissue (MALT) in extragastric organs is related to Helicobacter pylori infection or not. This report describes three patients with rectal MALT negative for H. infection, all whom showed disease regression after being treated antibiotics. One patient had both descending colon and rectum; other two only. None chronic gastritis which was detectable either endoscopically histologically completely ruled out by various methods,...
Abstract Background Pancreatic cancer is often diagnosed at advanced stages, and early-stage diagnosis of pancreatic difficult because nonspecific symptoms lack available biomarkers. Methods We performed comprehensive serum miRNA sequencing 212 patient samples from 14 hospitals 213 non-cancerous healthy control samples. randomly classified the into two cohorts: a training cohort ( N = 185) validation 240). created ensemble models that combined automated machine learning with 100 highly...