A5062185821- Influenza Virus Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- SARS-CoV-2 and COVID-19 Research
- IgG4-Related and Inflammatory Diseases
- Genomics and Rare Diseases
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Clinical Nutrition and Gastroenterology
- Genomic variations and chromosomal abnormalities
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Platelet Disorders and Treatments
- Gastrointestinal disorders and treatments
- Bacterial Infections and Vaccines
- Musculoskeletal synovial abnormalities and treatments
- Hepatitis C virus research
- Inflammatory Bowel Disease
- Intestinal and Peritoneal Adhesions
- Biomedical Research and Pathophysiology
- Cancer Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
Kyoto University
2016-2024
Kazusa DNA Research Institute
2019-2024
Center for Genomic Science
2019-2022
Nagasaki University
2012-2019
May Institute
2015
The University of Tokyo
2013
Molecular Oncology (United States)
2012
Tokyo Metropolitan Police Hospital
2003
Kumiai Chemical Industry (Japan)
1993
Women Medical College
1983-1985
In the field of genomic medical research, amount large-scale information continues to increase due advances in measurement technologies, such as high-performance sequencing and spatial omics, well progress made cohort studies involving more than one million individuals. Therefore, researchers require computational resources analyze this information. Here, we introduce a hybrid cloud system consisting an on-premise supercomputer, science cloud, public at Kyoto University Center for Genomic...
In Japan, there are approximately 300 projects conducting research on rare diseases supported by the Ministry of Health, Labour and Welfare Japan (MHLW) Agency for Medical Research Development (AMED). Diverse data, including clinical, genomic, sample-related generated these projects. However, at present, such data managed individually each project. This makes it difficult third parties to ascertain projects.Again this background, beginning 2017, AMED started National Platform Rare Diseases...
The seasonal influenza vaccine remains one of the vital recommended infection control measures for elderly with chronic illnesses. We investigated immunogenicity a single dose in 123 seronegative participants and classified them into four distinct groups, determined by promptness response, longevity humoral immunity, likelihood exhibiting cross-reactivity. Subsequently, we used transcriptional profiling differential gene expression analysis to identify potential genes directly associated...
To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound.Normal liver rats were divided into a DKT 90 mg/kg, 270 mg/kg administered group, and control, while cirrhotic DKT-LC group Control-LC. The after administration either or water for 60 min by laser flowmetry system.The in increased approximately 10 administrated, elevated levels maintained min. A comparison increase calculating area under curve (AUC) revealed that...
A 64-year-old Japanese man suffering from IgD λ myeloma and renal failure requiring chronic hemodialysis was treated with thalidomide. Serum concentration 4, 050 mg/dl cells constituted 95.6% of nucleated in bone marrow at the start treatment. These parameters improved markedly to 1, 590 22.0%, respectively, 4 months immediately prior his death due pneumonia. Thalidomide caused peripheral neuropathy constipation a dose 100 mg daily first week treatment, but adverse effects resolved upon...
In this study, we describe the development of a PCR-free whole exome sequencing method. Using method, 2 μg DNA was sufficient for library preparation sequencing. Furthermore, method is simple and makes use commercial kit, with additional step concentrating captured by ethanol precipitation. The accuracy found to be equivalent that unique molecular identifier-corrected analysis which commonly used detect rare mutations. Thus, cost-effective as well efficient in detecting
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease that leads to respiratory failure and death. Although there greater understanding of the etiology this disease, accurately predicting course in individual patients still not possible. This study aimed evaluate serum cytokines/chemokines as potential biomarkers can predict outcomes IPF patients. Methods A multi-institutional prospective two-stage discovery validation design using two...
The influenza vaccine administrated every year is a recommended infection control procedure for individuals above the age of six months. However, effectiveness repeated annual vaccination still an active research topic. Therefore, we investigated immunogenicity in two independent groups: previously vaccinated versus non-vaccinated at three time points; prior vaccination, one week and months post vaccination. assessment enabled us to evaluate elicited immune responses durability induced...
Esotropia and exotropia in the entity of comitant strabismus are multifactorial diseases with both genetic environmental backgrounds. Idiopathic superior oblique muscle palsy, as predominant non-comitant (paralytic) strabismus, also has a background, evidenced by varying degrees hypoplasia. A genome-wide association study (GWAS) was conducted 711 Japanese patients esotropia (n= 253), (n = 356), idiopathic palsy 102). The genotypes single nucleotide polymorphisms (SNPs) were determined...
Even with advanced plasmid and viral vectors, attaining copy numbers of multiple genes among different transfected cells is challenging. We achieved one gene expression from a single-copy in cell using transgene competition system, combination the Kazusa cDNA clones our dual recombinase-mediated cassette exchange system. All 48 nuclear receptors were simultaneously expressed dish at same level HEK293 this proliferation rate was compared. Significant differences observed between CMV- or EF1...
We started a registry for cases of immunoglobulin (Ig)G4-related disease (IgG4-RD) in December 2019 to clarify the clinical profile IgG4-RD. In this study, information from 854 registered by February 16, 2024 was analyzed multiple perspectives. Diagnosis IgG4-RD made 808 cases, comprising 638 definite, 38 probable, and 132 possible. The mean ± SD age at time enrollment 67.9 11.3 years, with 68.8% being male. pancreas most frequently affected organ (49.8%), followed submandibular glands...
症例は78歳の女性で，意識消失のため近医に救急搬送され，低血糖発作と診断された．腹部造影CTと選択的動脈内カルシウム注入試験で，膵鉤状突起に径17 mmの単発性の腫瘤を認めインスリノーマと診断された．術前低血糖管理のためブドウ糖点滴を試みるも，認知症のため自己抜去を繰り返し管理困難であった．オクトレオチド皮下注射に変更したところ血糖値は100～250 mg/dlで推移し低血糖発作は認めなかった．術中造影超音波で腫瘍の局在を確認し，腫瘍核出術を行った．術後血中インスリン値は基準値内となった．インスリノーマによる低血糖症状に対してはブドウ糖点滴，経口摂取で対応がなされるが，認知症例では血糖管理困難な場合も存在する．オクトレオチド皮下注射は患者負担の軽減につながり，術前の低血糖管理に有用と考えられた．
<h3>Background</h3> IgG4-related disease (IgG4RD) is an emerging concept of autoimmune entity including pancreatitis, sialadenitis and IgG-related kidney (Ref 1–3). Comprehensive genetic landscape IgG4RD unknown. <h3>Objectives</h3> To perform a genome-wide association study to detect susceptibility loci uncover the pathophysiology underlying IgG4RD. <h3>Methods</h3> We conducted two-staged composed total 850 cases 2,082 controls by genotyping 2,310,564 single nucleotide polymorphisms...
To prevent unexpected sudden cardiac patient death due to drug-induced Long QT syndrome (LQTS), we seek build a computerized early detection and warning system of QTc interval increase tendency. We built an ECG database that holds the digital waveform data related information ECGs performed in out hospital, developed experimental Despite several problems about accuracy detection, succeeded extracting who seemed be LQTS. A combination such with more drug prescription would contribute
Medication alert systems have been implemented worldwide. The purpose of this study is evaluation the medication from a clinical perspective. We surveyed physicians with regard to their reactions alerts. collected revised prescription information and assessed risk avoidance in all cases. system reviewed 51,006 prescriptions produced 16,718 physician alerts related 13,823 over course 1 month. identified 45 that were following four cases which patient treatment may discontinued or adverse drug...
There are more than 300 research groups for rare diseases in Japan. Although various clinical and genomic information of patients being collected by the groups, is managed individually each group current practices managing sharing data not very efficient. Since "rare diseases" literally rare, understanding underlying disease mechanisms incomplete collecting a sufficient number trials difficult. Therefore, there need to collect integrate construct integration platform research. Funded Japan...
Background: Intersphincteric resection (ISR) has become a common procedure for lower rectal cancer.However, while the anus can be preserved, thereby avoiding colostomy, anal sphincter dysfunction remains troublesome complication.This is serious problem with no effective therapies available at present.We established novel rat model long-term dysfunction.The objective of this experiment was to assess functional recovery after electrical muscle stimulation (EMS) in rats.Methods: Twenty female...
症例は52歳，女性．2005年2月に右乳癌（B領域）で，乳房温存手術・腋窩リンパ節郭清を施行された．病理組織学的診断は乳管内進展を伴う浸潤性乳管癌であった．術後放射線療法は希望されなかった．術後補助化学療法・内分泌療法を施行され，外来で経過観察されていた．2013年4月，右乳頭・乳輪部にびらん出現．生検でPaget細胞を認めたため，乳房温存術後Paget病の術前診断で残存乳房切除を行った．病理組織学的検査では乳頭部表皮内にPaget細胞を認め，その直下からB領域へ区域性に連続する乳管内進展像を示した．その癌分布範囲から，切除断端より発症したPaget再発と診断した．乳房温存術後8年目に発症したPaget再発であった．再発形式としては非常にまれであるが，早期発見・治療のためにはPaget再発も念頭に置いた乳房温存術後の厳重な経過観察が必要である．