A5101966931- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Pharmacogenetics and Drug Metabolism
- Chemical Reaction Mechanisms
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Synthesis of heterocyclic compounds
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Diet, Metabolism, and Disease
- Polyamine Metabolism and Applications
- Epilepsy research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Catalytic Processes in Materials Science
- Amino Acid Enzymes and Metabolism
- Cardiovascular Function and Risk Factors
- Biochemical Analysis and Sensing Techniques
- Fungal Biology and Applications
- Food Quality and Safety Studies
- Cardiac Valve Diseases and Treatments
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Pharmacological Receptor Mechanisms and Effects
- Garlic and Onion Studies
Hokuriku University
2002-2025
National Agriculture and Food Research Organization
2009-2024
Hyogo Prefectural Amagasaki General Medical Center
2011-2024
Nihonkai General Hospital
2012-2020
University of Miyazaki Hospital
2020
Food Research Institute
2018
Mayo Clinic
2018
Hirosaki University Hospital
2017
Mayo Clinic in Arizona
2016
The University of Kitakyushu
2011-2013
Mulberry 1-deoxynojirimycin (DNJ), a potent glucosidase inhibitor, has been hypothesized to be beneficial for the suppression of abnormally high blood glucose levels and thereby prevention diabetes mellitus. However, DNJ contents in commercial mulberry products were as low about 0.1% (100 mg/100 g dry product), implying that bioavailability might not expected. We carried out studies two directions: (1) production food-grade powder containing maximally content; (2) determination optimal dose...
Abstract We analyzed the bilirubin uridine diphosphate‐glucuronosyltransferase (B‐UGT) gene in 42 Japanese newborns with hyperbilirubinemia and determined that 21 infants were heterozygous while 3 was homozygous for Gly71Arg. Allele frequency of Gly71Arg 0.32 hyperbilirubinemia, which significantly higher than 0.13 healthy controls. This mutant allele is also prevalent among Korean Chinese controls a 0.23 both populations. However, this mutation not detected 50 German These data suggest high...
Interactions of anandamide (N-arachidonylethanolamide), an endogenous compound for cannabinoid receptors, with the receptors 5-hydroxytryptamine (5-HT), benzodiazepine, and γ-aminobutyric acidA (GABAA) in bovine synaptic membrane were examined. Anandamide decreased 5-HT receptor bindings at concentrations 1-100 μM, although it did not cause any change benzodiazepine or GABAA bindings. A high concentration anandamide, 100μM, significantly decrease both [3H]5-HT [3H]ketanserin The present...
1-deoxynojirimycin (DNJ), a potent glucosidase inhibitor, is characteristic constituent of the mulberry leaf. Dietary DNJ may be beneficial for suppression abnormally high blood glucose levels, thereby preventing diabetes mellitus. Although there considerable interest in effects DNJ, intestinal absorption and pharmacokinetic profile orally administered have never been characterized. In this study, we developed method determining level plasma by hydrophilic interaction chromatography coupled...
The effect of 1-deoxynojirimycin, a caloric restriction mimetic, was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is carcinogen (10 mg/kg body weight), and 2% sulfate (w/v) used as colitis-inducing agent. Mice were separated into 5 groups: group without cancer fed normal diet (CO- group), groups (CO+ calorie-restricted (caloric diets including 0.02% 0.1% 1-deoxynojirimycin (l-1-deoxynojirimycin H-1-deoxynojirimycin groups). tumor...
Background: Plaque characteristics associated with effective intravascular lithotripsy (IVL) treatment of calcification have not been investigated. This study identified calcified plaque that favor the use IVL.
Abstract Background Pancreatic cancer is often diagnosed at advanced stages, and early-stage diagnosis of pancreatic difficult because nonspecific symptoms lack available biomarkers. Methods We performed comprehensive serum miRNA sequencing 212 patient samples from 14 hospitals 213 non-cancerous healthy control samples. randomly classified the into two cohorts: a training cohort ( N = 185) validation 240). created ensemble models that combined automated machine learning with 100 highly...
1-Deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor and thus beneficial for prevention of diabetes. While we have succeeded in obtaining the culture supernatant extract (CSE) rich DNJ from microorganism source, information regarding its anti-hyperglycemic effect safety were still limited. Therefore, this study was aimed to evaluate DNJ. Oral sucrose tolerance test performed, result showed that CSE able significantly suppress blood glucose elevation suggested as main active compound....
Frailty is characterized by reduced biological reserves and weakened resistance to stressors, common in older adults. This study evaluated the prognostic implications of frailty at hospitalization elderly patients with acute myocardial infarction (AMI) who undergo percutaneous coronary intervention (PCI).We prospectively analysed 546 AMI aged ≥80 years undergoing PCI from 2009 2017. was classified based on impairment walking (unassisted, assisted, wheelchair/non-ambulatory), cognition...
Two genes, encoding YK-LiP1 and YK-LiP2, were cloned from the white-rot fungus Phanerochaete sordida YK-624, a homologous expression system for gene was constructed. full-length cDNAs (ylpA ylpB) isolated by degenerate RT-PCR RACE-PCR. The results of N-terminal amino acid sequence analysis native YK-LiP2 showed that ylpA ylpB coded respectively. promoter glyceraldehyde-3-phosphate dehydrogenase P. YK-624 (PsGPD) used to drive ylpA. Expression vector pGPD-g-ylpA transformed into uracil...
Abstract White adipose tissue (eWAT) plays a crucial role in preventing metabolic syndrome. We aimed to investigate WAT distribution and gene expression lipidomic profiles epididymal diet-induced obese mice, reflecting Western-style diet of humans elucidate the bioactive properties dietary antioxidant curcumin lifestyle-related diseases. For 16 weeks, we fed C57BL/6J mice with control diet, high-fat, high-sucrose high-cholesterol Western or supplemented 0.1% ( w / ) curcumin. Although intake...
Patients with only moderate atrial secondary mitral regurgitation (asMR) frequently develop heart failure (HF). Mechanisms of HF asMR and the impact mild remain unclarified. Although mild/moderate primary is compensated by left ventricular (LV) dilatation, LV not dilated in asMR. We hypothesized that patients without dilatation may have impaired hemodynamics higher risks subsequent symptomatic deterioration.
Endovascular therapy (EVT) with devices such as drug-coated balloons (DCBs) and drug-eluting stents (DESs) for atherosclerotic disease in the femoropopliteal (FP) artery has been established. However, EVT using drug-based chronic limb-threatening ischemia (CLTI) remains challenging. The optimal device FP lesions patients CLTI unknown. This study compared clinical efficacy of DCB DES lesions.
This study investigated the pharmacokinetic and pharmacodynamic profile of tolvaptan, verified its efficacy safety in patients with liver cirrhosis-associated ascites, insufficient response to conventional diuretic treatment.This multicentre, double-blind, parallel-group allocated cirrhosis receive either 3.75 or 7.5 mg/day tolvaptan orally, once daily, for 7 days. Pharmacokinetic, variables were measured.Tolvaptan was shown have high plasma concentrations, prolonged duration maximum...
Background: Little is known on the mechanism of acute ischemic mitral regurgitation (IMR) caused by sudden-onset left ventricular dysfunction in myocardial infarction (MI). We sought to investigate valve (MV) complex geometry IMR comparison with chronic 2-dimensional and 3-dimensional transthoracic echocardiography. Methods Results: Forty-four first-onset MI 36 previous ≥moderate were examined 2-dimensional/3-dimensional MV morphology was quantitatively analyzed compared between 2 groups....
Abstract Aims Mechanisms of chronic ischaemic mitral regurgitation (IMR) are well-characterized by apically tethered leaflet caused papillary muscles (PMs) displacement and adynamic apparatus. We investigated the unique geometry dynamics apparatus in first acute myocardial infarction (MI) using quantified 3D echocardiography. Methods results prospectively performed echocardiography 2.3 ± 1.8 days after MI, 174 matched patients with (n = 87) without IMR 87). left ventricular (LV) volumes...