A5078984314- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Bioactivity Studies
- Glycosylation and Glycoproteins Research
- Enzyme-mediated dye degradation
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- X-ray Diffraction in Crystallography
- Plant biochemistry and biosynthesis
- Carbohydrate Chemistry and Synthesis
- Phytochemical compounds biological activities
- Silymarin and Mushroom Poisoning
- Mycorrhizal Fungi and Plant Interactions
- Enzyme Production and Characterization
- Biofuel production and bioconversion
- Toxin Mechanisms and Immunotoxins
- Plant-derived Lignans Synthesis and Bioactivity
- Photosynthetic Processes and Mechanisms
- Natural product bioactivities and synthesis
- Microbial Metabolites in Food Biotechnology
- Biochemical and biochemical processes
- Microbial Metabolic Engineering and Bioproduction
Shizuoka University
2016-2025
Japan Society for the Promotion of Science
2022
Graduate School USA
2010-2014
University of Shizuoka
2010
University of Yamanashi
2010
Gifu University
2007
Industrial Research Institute of Shizuoka Prefecture
2002-2003
Osaka University
2000
Centre National de la Recherche Scientifique
1998
Hokkaido University
1979-1994
Abstract It has been known for many years that most fungi which have effects against cancers of the stomach, esophagus, lungs, etc., belong to Polyporacea. However, components responsible such action not clearly defined. In Japan, in 1968, it was reported a hot water extract from some edible mushrooms belonging Polyporacea showed marked host‐mediated antitumor activity. Since then, numerous researchers isolated active materials and identified them be (1—3)‐ß‐D‐glucopyranans with...
To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). As assessed plasma aminotranferase activities, nutmeg showed most potent activity. Bioassay-guided isolation active compound from was carried out in mice a single oral administration respective fractions. Myristicin, one major essential oils nutmeg, found possess extraordinarily Myristicin markedly suppressed...
Aflatoxin B(1) (AFB(1) ) is a potent mycotoxin with mutagenic, carcinogenic, teratogenic, hepatotoxic, and immunosuppressive properties. In order to develop bioremediation system for AFB(1) -contaminated foods by white-rot fungi or ligninolytic enzymes, was treated manganese peroxidase (MnP) from the fungus Phanerochaete sordida YK-624. eliminated MnP. The maximum elimination (86.0%) of observed after 48 h in reaction mixture containing 5 nkat addition Tween 80 enhanced elimination. MnP...
This study examined the role of degree polymerization (DP) inulin-fructans in modulating interaction between lactic acid bacteria and IgA cecal secretion. Rats were fed a control diet or containing one fructans with different DP. Consuming increased concentrations order DP4 > DP8 DP16. Cecal lactobacilli counts higher DP4, DP8, DP16, whereas bifidobacteria DP23. correlated (P < 0.01). but not DP23, significantly IgA-producing plasma cells mucosa. IFN-γ IL-10 production CD4+ T was enhanced...
To develop the versatile methodology for genome mining of mushroom metabolites, we examined production bioactive diterpenes erinacines using genomic DNA sequences. In this report, initially identified high expression loci (hot spots) in Aspergillus oryzae by sequencing DNAs from highly yielding transformants which were obtained our previous biosynthetic studies. Genome editing knock-in all erinacine genes directly to hot spot showed that A. correctly spliced more than 90% introns gene Then,...
Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Hericium erinaceum. The structures compounds determined by interpretation spectral data. Erinacine showed stimulating activity nerve growth factor (NGF)-synthesis.
(1995). Reishi, Ganoderma lucidum and tsugae: Bioactive substances medicinal effects. Food Reviews International: Vol. 11, Mushrooms: The Versatile Fungus-Food Medicinal Properties, pp. 151-166.
Two anthocyanins, cyanidin-3-α-O-rhamnoside (C3R) and pelargonidin-3-α-O-rhamnoside (P3R), quercitrin (quercetin-3-α-O-rhamnoside), were isolated from acerola (Malpighia emarginata DC.) fruit. These polyphenols evaluated based on the functional properties associated with diabetes mellitus or its complications, that is, radical scavenging activity inhibitory effect both α-glucosidase advanced glycation end product (AGE) formation. C3R revealed strong activity. While profiles of except towards...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis lung alveolar epithelial cells plays role in progression. This intractable associated with increased abundance Staphylococcus Streptococcus the lungs, yet their roles pathogenesis remain elusive. Here, we report that nepalensis releases corisin, peptide conserved diverse staphylococci, to induce cells. The mice exhibits acute exacerbation after intrapulmonary instillation...
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in poor quality of life negative health outcomes. One central question surrounding frailty whether phenotypic the impairment during aging. Using spontaneous behavioral tests by studying dynamic change aging, we demonstrated that two form vulnerability, recognition memory develop parallel therefore, integration motoric evaluations are imperative. We developed an integrated index based on...
A novel diterpenoid, erinacine D, was isolated from the cultured mycelia of Hericium erinaceum.The structure compound determined by interpretation spectral data and chemical reaction.This showed stimulating activity nerve growth factor (NGF)synthesis.