A5065989164- Metal complexes synthesis and properties
- China's Socioeconomic Reforms and Governance
- Fungal Biology and Applications
- Economic Zones and Regional Development
- French Urban and Social Studies
- Medicinal Plants and Bioactive Compounds
- China's Global Influence and Migration
- Globalization and Cultural Identity
- RNA Interference and Gene Delivery
- Hong Kong and Taiwan Politics
- Histone Deacetylase Inhibitors Research
- RNA and protein synthesis mechanisms
- Ferrocene Chemistry and Applications
- Eating Disorders and Behaviors
- Vehicle Noise and Vibration Control
- Urban Design and Spatial Analysis
- Antimicrobial Peptides and Activities
- Japanese History and Culture
- Soil Management and Crop Yield
- Global Urban Networks and Dynamics
- Hygrothermal properties of building materials
- Phytochemistry and Biological Activities
- Origins and Evolution of Life
- Lanthanide and Transition Metal Complexes
- Engineering Technology and Methodologies
Policlinico San Matteo Fondazione
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2025
University of Pavia
2018-2024
Biogem
2021
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in poor quality of life negative health outcomes. One central question surrounding frailty whether phenotypic the impairment during aging. Using spontaneous behavioral tests by studying dynamic change aging, we demonstrated that two form vulnerability, recognition memory develop parallel therefore, integration motoric evaluations are imperative. We developed an integrated index based on...
The current standard oncotherapy for glioblastoma is limited by several adverse side effects, leading to a short-term patient survival rate paralleled worsening quality of life (QoL). Recently, Complementary and Integrative Medicine’s (CIM) innovative approaches have shown positive impacts in terms better response treatment, effect reduction, QoL improvement. In particular, promising potential cancer therapy has been found compounds coming from phyto- mycotherapy. objective this study was...
Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited effect of a novel blend, namely Micotherapy U-care, in 4T1 triple-negative mouse model. Mice were orally administered with consisting mixture Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice...
Myelodysplastic syndromes (MDS) are clonal stem cell disorders driven by heterogeneous genetic alterations leading to variable clinical course. MDS with splicing factor SF3B1 mutations is a distinct subtype favorable outcome. However, selected co-mutations induce poor prognosis and how these lesions cooperate in human hematopoietic progenitor cells (HSPCs) during disease progression still unclear. Here, we integrated molecular profiling of patients gene editing primary iPSC-derived HSPCs...
Glioblastoma (GBM) is the most common tumor of central nervous system. Current therapies, often associated with severe side effects, are inefficacious to contrast GBM relapsing forms. In trying overcome these drawbacks, ( OC -6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(IV), also called Pt(IV)Ac-POA, has been recently synthesized. This new prodrug bearing as axial ligand (2-propynyl)octanoic acid (POA), a histone deacetylase inhibitor, higher activity due (i) its high...
The insertion of perillic acid in cisplatin-based antitumor Pt(<sc>iv</sc>) prodrugs confers them antimetastatic properties.
The extracellular matrix is essential for brain development, lamination, and synaptogenesis. In particular, the basement membrane below pial meninx (pBM) required correct cortical development. last step in catabolism of most abundant protein pBM, collagen Type IV, requires prolidase, an exopeptidase cleaving imidodipeptides containing pro or hyp at C-terminal end. Mutations impairing prolidase activity lead humans to rare disease deficiency characterized by severe skin ulcers mental...
Anorexia nervosa (AN) is an eating disorder (ED) that has seen increase in its incidence the last thirty years. Compared to other psychosomatic disorders, ED can be responsible for many major medical complications, moreover, addition various systemic impairments, patients with AN undergo morphological and physiological changes affecting cerebral cortex. Through immunohistochemical studies on portions of postmortem human brain people affected by healthy individuals, western blot leucocytes...
Interactions of transmembrane (TM) helices play a key role in many cell processes. The configuration and cross angle these adopt are traditionally attributed to specific residue interactions. We present different approach, which residues disregarded, the membrane TM helix packing is investigated. introduce coarse-grained model obtain their characteristic configurations both as single paired helices. Our analysis shows that hydrophobic mismatch has substantial effect determining not only tilt...