A5007114143- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Muscle metabolism and nutrition
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Immune Cell Function and Interaction
- Heart Rate Variability and Autonomic Control
- Exercise and Physiological Responses
- Nutrition and Health in Aging
- Cardiac pacing and defibrillation studies
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac Health and Mental Health
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Mechanical Circulatory Support Devices
- Blood Pressure and Hypertension Studies
- Sports Performance and Training
Kyushu University
2001-2025
Hokkaido University
2013-2022
Juntendo University
1999-2021
Japan Agency for Medical Research and Development
2021
Kurume University
2021
Yamaguchi University
2021
Shinshu University
2021
Nagasaki University
2021
Hokkaido University Hospital
2018
American Heart Association
2013
Abstract —Oxidative stress in the myocardium may play an important role pathogenesis of congestive heart failure (HF). However, cellular sources and mechanisms for enhanced generation reactive oxygen species (ROS) failing remain unknown. The amount thiobarbituric acid substances increased canine HF hearts subjected to rapid ventricular pacing 4 weeks, immunohistochemical staining 4-hydroxy-2-nonenal ROS-induced lipid peroxides was detected cardiac myocytes but not interstitial cells animals....
Abstract —Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for ROS determine contribution superoxide anion (·O 2 − ), H O , hydroxy radical (·OH) myocardial tissue. Heart failure was produced adult mongrel dogs by rapid ventricular pacing at 240 bpm 4 weeks. To assess directly, freeze-clamped tissue homogenates were reacted with nitroxide radical,...
Background: Heart failure (HF) with preserved ejection fraction (EF) is common. We compared the characteristics, treatments, and outcomes in HF patients reduced vs EF by using national registry database Japan. Methods Results: The Japanese Cardiac Registry of Failure Cardiology (JCARE-CARD) a prospective observational study broad sample hospitalized worsening HF. enrolled 2,675 from 164 hospitals an average 2.4 years follow-up. Patients (EF ≥50% echocardiography; n=429) were more likely to...
PAD peripheral arterial disease PCI percutaneous coronary intervention peak V ˙O2 oxygen uptake PH pulmonary hypertension PVCs premature ventricular contraction QOL quality of life RCT randomized controlled trial RPE rating perceived exertion SGA Subjective Global Assessment STEMI ST elevation myocardial infarction TG triglyceride TAVI transcatheter aortic valve implantation VAD assist device ˙CO2 carbon dioxide output ˙E minute ventilation ˙E/V ventilatory equivalent for vs. slope ˙O2/HR...
Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) a pattern recognition receptor positively regulating response to mtDNA inflammatory cells, fibroblasts, and endothelial cells. However, the role of remodeling remains unclear. The aim this study was elucidate mtDNA-induced cardiomyocytes failing hearts.mtDNA administrated into isolated cardiomyocytes. Myocardial infarctionwas conducted wild type knockout...
Oxidative stress might play an important role in the progression of left ventricular (LV) remodeling and failure that occur after myocardial infarction (MI). We determined whether reactive oxygen species (ROS) are increased LV experimental MI with use electron spin resonance spectroscopy long-term administration dimethylthiourea (DMTU), hydroxyl radical (.OH) scavenger, could attenuate these changes. studied 3 groups mice: sham-operated (sham), MI, animals received DMTU (MI+DMTU). Drugs were...
Background — Short-term administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, has been shown to attenuate ischemia-reperfusion injury. However, the effects long-term statins on left ventricular (LV) remodeling and failure after myocardial infarction remain unknown. Methods Results Mice were subjected coronary artery ligation treated for 4 weeks with vehicle or fluvastatin (10 mg/kg per day PO). Fluvastatin increased survival (61% versus 86%; P...
Mitochondrial oxidative stress and damage play major roles in the development progression of left ventricular (LV) remodeling failure after myocardial infarction (MI). We hypothesized that overexpression mitochondrial antioxidant, peroxiredoxin-3 (Prx-3), could attenuate this deleterious process.We created MI 12- to 16-week-old, male Prx-3-transgenic mice (TG+MI, n=37) nontransgenic wild-type (WT+MI, n=39) by ligating coronary artery. Prx-3 protein levels were 1.8 times higher hearts from TG...
Although recent studies have reported that low-intensity resistance training with blood flow restriction could stress the muscle effectively and provide rapid hypertrophy strength gain equivalent to those of high-intensity training, exact mechanism its generality not yet been clarified. We investigated intramuscular metabolism during exercise compared it exercises without using 31 P-magnetic resonance spectroscopy. Twenty-six healthy subjects (22 ± 4 yr) participated performed unilateral...
Our previous study reported that intramuscular metabolic stress during low-intensity resistance exercise was significantly enhanced by combining blood flow restriction (BFR); however, they did not reach the levels achieved high-intensity exercise. That performed using a single set of exercise; usual consists multiple sets with rest intervals. Therefore, we investigated multiple-set BFR exercises, and compared results those Twelve healthy young subjects 3 1-min unilateral plantar flexion (30...
Our previous study reported that metabolic stress in skeletal muscle achieved by combining moderate blood flow restriction (BFR) with low-intensity resistance exercise at 20% of one repetition maximum (1 RM) could not reach the level high-intensity exercise. Since protocol is typical current regimens this type, we sought to optimize for BFR examining dose effects intensity and pressure. Twelve healthy subjects participated study. They were asked perform unilateral plantar flexion 2 min (30...
Insulin resistance or diabetes is associated with limited exercise capacity, which can be caused by the abnormal energy metabolism in skeletal muscle. Oxidative stress involved mitochondrial dysfunction diabetes. We hypothesized that increased oxidative could cause muscle and make contribution to intolerance C57/BL6J mice were fed on normal diet high fat (HFD) for 8 wk induce obesity insulin Treadmill tests expired gas analysis performed determine capacity whole body oxygen uptake (Vo(2))....
Skeletal muscle bulk and strength are becoming important therapeutic targets in medicine. To increase mass, however, intensive, long-term mechanical stress must be applied to the muscles, such is often accompanied by orthopedic cardiovascular problems. We examined effects of circulatory occlusion resistance training combined with a very low-intensity load on enhancing muscular metabolic thereby increasing bulk. Muscular stress, as indicated increases inorganic phosphate (P(i)) decrease...
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
Abstract Aims Cardiac rehabilitation (CR) is an evidence‐based, secondary preventive strategy that improves mortality and morbidity rates in patients with heart failure (HF). However, the implementation continuation of CR remains unsatisfactory, particularly for outpatients physical frailty. This study investigated efficacy safety a comprehensive home‐based cardiac (HBCR) programme combines patient education, exercise guidance, nutritional guidance using information communication technology...
Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which a complication of critical illness in the ICU; however, there are no reports on pathogenesis and early predictors ICU-AW specifically associated with cardiogenic shock (CS). Therefore, this study aimed to investigate clinical characteristics patients CS requiring mechanical circulatory support (MCS). This was single-center, prospective, observational study. Patients aged 16 years...
Matrix metalloproteinases (MMPs) play an important role in the extracellular matrix remodeling. Experimental and clinical studies have demonstrated that MMP 2 9 are upregulated dilated failing hearts involved development progression of myocardial However, little is known about MMPs mediating adverse remodeling response to chronic pressure overload (PO). We, thus, hypothesized selective disruption gene could ameliorate PO-induced cardiac hypertrophy dysfunction mice. PO was induced by...