A5032288937- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac and Coronary Surgery Techniques
- Cardiac Imaging and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Aortic aneurysm repair treatments
- Pluripotent Stem Cells Research
- Pulmonary Hypertension Research and Treatments
- Mesenchymal stem cell research
- Viral Infections and Immunology Research
- Fuel Cells and Related Materials
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Infectious Aortic and Vascular Conditions
- Congenital heart defects research
Saitama Medical University
2019-2025
Dokkyo Medical University Saitama Medical Center
2023-2025
Social Insurance Saitama Chuo Hospital
2023-2025
Dokkyo Medical University
2023-2025
Osaka University
2015-2024
Japanese Circulation Society
2024
Saitama International Medical Center
2020-2024
Harvard University
2023
National Cerebral and Cardiovascular Center
2010-2022
Osaka University Hospital
2013-2022
encompassing the estimated benefit in proportion to risk (Tables 1,2).
Background— Transplantation of cardiomyocytes that are derived from human induced pluripotent stem cell–derived (hiPS-CMs) shows promise in generating new functional myocardium situ, whereas the survival and functionality transplanted cells critical considering this therapeutic impact. Cell-sheet method has been used to transplant many cells; however, potential ischemia might limit cell survival. The omentum, which is known have rich vasculature, expected be a source blood supply. We...
Background When transplanted into failing heart, autologous somatic tissue–derived cells yield functional recovery via paracrine effects that enhance native regeneration. However, the therapeutic are modest. We developed a method in which scaffold‐free cell sheets attached to epicardial surface maximize effects. This Phase I clinical trial tested whether transplanting cell–sheets derived from skeletal muscle is feasible, safe, and effective for treating severe congestive heart failure....
In this study, we proposed that the functionality or phenotype of differentiated cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CMs) might be modified by co-culture with mesenchymal (MSCs), resulting in an improved therapeutic potential for failing myocardial tissues. Structural, motility, electrophysiological, and metabolic analyses revealed iPSC-CMs co-cultured MSCs displayed aligned myofibrils A-, H-, I-bands could contract relax quickly, indicating promotion...
Background:Poor survival outcomes for patients with severe heart failure (HF) and the donor shortage transplantation warrant development of myocardial regenerative therapy. We performed a multicenter, phase II study to evaluate safety efficacy autologous skeletal myoblast sheets (TCD-51073).Methods Results:In 3 sites, we enrolled 7 chronic HF due ischemic disease despite maximal therapy, all whom underwent TCD-51073. No serious arrhythmia was reported, no changes were noted in frequency...
Abstract Transplant of human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) cell-sheet is a promising approach for treating ischemic cardiomyopathy (ICM). However, poor blood supply to the transplanted concern related effectiveness and durability treatment. Herein, we hypothesized that combined omentum flap might enhance survival therapeutic effects hiPS-CM transplant ICM Treatment by Wnt signaling molecules in hiPS cells produced hiPS-CMs, which were magnetically labeled...
Despite major therapeutic advances, heart failure, as a non-communicable disease, remains life-threatening disorder, with 26 million patients worldwide, causing more deaths than cancer. Therefore, novel strategies for the treatment of failure continue to be an important clinical need. Based on preclinical studies, allogenic human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) patches have been proposed potential candidate failure. We report implantation allogeneic hiPSC-CM in...
The Impella
Background In patients with cardiogenic shock (CS), acute myocardial infarction (AMI) is the most common cause, and a percutaneous microaxial ventricular assist device (Impella, Abiomed, Danvers, MA) choice for temporary mechanical circulatory support. However, data are limited on complications outcomes of Impella treatment in CS without AMI. Methods Results Using nationwide prospective registry Japan, we included total 2047 whom devices were successfully placed between February 2020...
Purpose:To assess the significance of aortic remodeling in prevention late events after thoracic endovascular repair (TEVAR) for dissection. Methods:The study involved 52 patients (41 men; mean age was 59.7±13.3 years) with type B dissections and patent false lumens treated TEVAR between 2004 2011. Of patients, 18 were acute phase rupture (n=1), malperfusion (n=10), diameter over 40 mm at onset (n=3), rapid enlargement lumen (n=4). In chronic setting, indications (n=2), >50 (n=18), (n=13)....
Abstract Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal cells (MSCs) can suppress rejection. To determine whether MSC co-transplantation reduce iPSC-CM transplantation, the latter cell type, harbouring luciferase transgene, was subcutaneously transplanted alone or together with syngeneic MSCs into BALB/c mice. Bioluminescence imaging revealed that significantly improved graft survival...
2 JCS/JSCVS/JCC/CVIT 2023 Guideline Focused Update on Indication and Operation of PCPS/ECMO/IMPELLA individual facilities.Therefore, in this Focus Update, specific classes or levels evidence are not strictly mandatory, but rather they presented as expert consensus.However, we strongly hope that will (1) serve a guideline for the standardization PCPS, ECMO, IMPELLA therapy within Japan, (2) be widely used by various healthcare professionals including physicians, nurses, clinical engineers,...
Introduction: Porphyromonas gingivalis , a major periodontal pathogen, is gaining increasing attention for its possible association with cardiovascular diseases. Its fimbriae are classified into six genotypes (types I–V and Ib) based on the diversity of fimA genes encoding fimbrial subunits. In this study, genotypic distribution was analyzed in P. ‐infected specimens. Methods: A total 112 heart valves 80 atheromatous plaque specimens were collected from patients undergoing surgery, as well...
The involvement of oral bacteria in the pathogenesis cardiovascular disease has been studied, with Streptococcus mutans, a pathogen dental caries, detected lesions at high frequency. However, no information is available regarding properties S. mutans those lesions. Heart valve specimens were collected from 52 patients and atheromatous plaque 50 patients, all whom underwent operations, taken 41 subjects prior to surgery. Furthermore, saliva samples 73 sets healthy mothers (n=73) their...