A5101775403- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Renin-Angiotensin System Studies
- Peroxisome Proliferator-Activated Receptors
- Nutritional Studies and Diet
- Neuroscience of respiration and sleep
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Edible Oils Quality and Analysis
- Glioma Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Amino Acid Enzymes and Metabolism
- Papaya Research and Applications
- Liver physiology and pathology
- Liver Disease and Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
Kitasato University
2015-2024
Cystic Fibrosis Trust
2023
Osaka University
2020
National Cerebral and Cardiovascular Center
2011-2015
Food and Drug Safety Center
1997-2013
Juntendo University
2008
Immunology Research Institute in Gifu
2008
University of Tsukuba
1990-1992
Hiroshima University
1975-1989
Columbia University Irving Medical Center
1989
MicroRNAs (miRNAs) are endogenous small RNAs that 18–23 nucleotides long. Recently, plasma miRNAs were reported to be sensitive and specific biomarkers of various pathological conditions. In the present study, we focused on miR-210, which is known induced by hypoxia might therefore an excellent biomarker for congestive heart failure. Plasma miR-210 levels expression in mononuclear cells skeletal muscles elevated Dahl salt-sensitive rats with We also assessed patients The NYHA III IV failure...
The P2X(7) receptor is a ligand-gated ion channel, and genetic variations in the gene significantly affect blood pressure. expression associated with renal injury inflammatory diseases. Uninephrectomized wild-type (WT) P2X(7)-deficient (P2X(7) KO) mice were subcutaneously implanted deoxycorticosterone acetate (DOCA) pellets fed an 8% salt diet for 18 days. Their pressure was assessed by telemetry system. placed metabolic cages, urine collected 24 h to assess function. After days of DOCA-salt...
Journal Article Comparison of the histological changes in skin DBA/2 and C57BL/6 mice following exposure to various promoting agents Get access Masashi Naito, Naito The University Texas System Cancer Center, Science Park—Research DivisionSmithville, TX 78957, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Yukiko John DiGiovanni Carcinogenesis, Volume 8, Issue 12, December 1987, Pages 1807–1815, https://doi.org/10.1093/carcin/8.12.1807 Published: 01 1987...
Hepatic triglyceride (TG) accumulation is considered to be a prerequisite for developing nonalcoholic fatty liver (NAFL). Peroxisomes have many important functions in lipid metabolism, including acid β-oxidization. However, the pathogenic link between NAFL and peroxisome biogenesis remains unclear. To examine molecular physiological of Pex11α gene, we disrupted this gene mice. Body weights hepatic TG concentrations Pex11α(-/-) mice were significantly higher than those wild-type (WT) fed...
Abstract MicroRNA (miR)-mediated regulation of protein abundance is a pervasive mechanism directing cellular processes. The well-studied and abundant miR-182 has previously been implicated in many aspects T cell function, DNA repair, cancer. In this study, we show that the most highly induced miR B cells undergoing class-switch recombination. To elucidate requirement lymphocyte extensively characterized mice with targeted deletion Mir182. We despite its dramatic induction, loss minimal...
Journal Article Susceptibility to phorbol ester skin tumor promotion in (C57BL/6×DBA/2) F 1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement Get access Masashi Naito, Naito The University of Texas System Cancer Center, Science Park Research DivisionSmithville, TX 78957, USA Search other works by this author on: Oxford Academic PubMed Google Scholar Kristine J. Chenicek, Chenicek Yukiko John DiGiovanni To whom reprint requests should be sent...
Salmonella enteritidis infection has received attention during recent years owing to its high prevalence worldwide. In the present study, protective effect of probiotic dahi (curd) supplemented with Lactobacillus acidophilus and L. casei against in mice is investigated. Seven days pre-feeding significantly increased anti- S. sIgA (secretary IgA) antibodies lymphocyte proliferation infected mice. IL-2, IL-6 IFNγ production were supernatant cultured splenocytes collected from pre-fed dahi,...
Pirfenidone (PFD) is a novel anti-fibrotic agent that targets TGFβ. However, the mechanisms underlying its renoprotective properties in hypertension-induced renal injury are poorly understood. We investigated of PFD and clarified rat model. Dahl salt-sensitive rats were fed high-salt diet with or without 1% for 6 weeks. During administration period, we examined effects on blood pressure function. After administration, protein levels TGFβ, Smad2/3, TNFα, MMP9, TIMP1, catalase examined. In...
MicroRNAs (miRNAs) are endogenous small RNAs of 18–23 nucleotides that regulate gene expression. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In the present study, we explored whether miRNA expression profiling muscle cells may be useful diagnosis diseases involving necrosis. was assessed by array and real-time reverse-transcriptase polymerase chain reaction using a reverse primer stem loop structure. Profiling mouse, including cardiac muscles, skeletal...
Abstract The antiinflammatory effect of an ointment containing propolis extract (3%–7%) was examined using carrageenan‐induced hind paw edema in rats. Treatment with the inhibited moderately, and inhibition significant at 5% 7%. Additionally, on chemotaxis human polymorphonuclear leukocytes (PMNs) investigated agarose plate method. Migration PMNs toward zymosan‐treated serum presence ointment. These results demonstrate that topical application is effective inhibiting rat edema, its...
The aim of this study was to investigate the effects administration oral arachidonic acid (AA) in rats with or without dextran sulphate sodium (DSS)-induced inflammatory bowel disease. Male Wistar were administered AA at 0, 5, 35 240 mg/kg daily by gavage for 8 weeks. Inflammatory disease induced replacing drinking water 3 % DSS solution during last 7 d dosing period. These animals passed loose stools, diarrhoea and red-stained faeces. Cyclo-oxygenase-2 concentration myeloperoxidase activity...
Abstract Background: The rates of acquisition and spontaneous eradication Helicobacter pylori infection in children has yet to be established. To determine these living an urban region Japan, the levels urine H. antibodies three different age groups were measured. Methods: A urine‐based enzyme‐linked immunosorbent assay (ELISA) was used detect twice within a 12 month interval over 2 years 452 healthy Tokyo. subjects divided into groups: ages 4, 7, 10 years. Results: prevalence not among...
Background: Mac-2 binding protein (M2BP) is a highly glycosylated secreted glycoprotein that involved in immune defense and regulation. Our cross-sectional studies indicated serum M2BP was useful liver fibrosis biomarker for nonalcoholic fatty disease (NAFLD). In this study, we conducted 7-year longitudinal study to investigate the significance of levels (baseline at follow-up) their relationships with other metabolic parameters disease. Methods: We enrolled 715 subjects (521 male 194...