A5089225322- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Galectins and Cancer Biology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Food Allergy and Anaphylaxis Research
- Gastrointestinal motility and disorders
- Colorectal Cancer Screening and Detection
- Adolescent and Pediatric Healthcare
- Asthma and respiratory diseases
- Celiac Disease Research and Management
- Intestinal Malrotation and Obstruction Disorders
- Child Nutrition and Feeding Issues
- Cardiac, Anesthesia and Surgical Outcomes
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
- Diet and metabolism studies
- Veterinary medicine and infectious diseases
- Anesthesia and Sedative Agents
Juntendo University
2016-2025
Showa Inan General Hospital
2020-2024
Satou Hospital
2024
Asahikawa Medical University
2023
Weatherford College
2023
Japan Pediatric Society
2017-2022
Iowa Digestive Disease Center
2020
The Japanese Society of Gastroenterological Surgery
2020
Ministry of Health Labour and Welfare
2018
Tokyo Metropolitan Children's Medical Center
2017
<h3>Background and Aims:</h3> Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production bowel disease (IBD) are still unclear. <h3>Methods:</h3> Endoscopic biopsies or surgical specimens were taken from inflamed uninflamed colonic mucosa 72 patients with IBD (38 Crohn’s 34 ulcerative colitis), normal colon 38 control subjects. IL17 interferon γ (IFNγ) detected by ELISA supernatants cultured ex vivo,...
ABSTRACT Objectives: Transforming growth factor (TGF) β1 displays a broad spectrum of activities in mucosal regulation, including induction oral tolerance, potent anti‐inflammatory effects, IgA expression and effects on epithelial cell proliferation differentiation. The present study examined the effect probiotics immunologic system preterm infants relation to TGF‐β signaling. Methods: Subjects comprised 19 divided into 2 groups: receiving Bifidobacterium breve supplementation ( B. group)...
Lower gastrointestinal bleeding (LGB), particularly in newborns, is of serious concern and requires urgent investigation hospital care. Whereas allergic proctocolitis caused by food protein a significant cause LGB infants with eosinophilia, there are several cases diseases symptoms similar to those but without an apparent reaction influence.We examined 2 neonates using rectosigmoidoscopy who showed eosinophilia experienced fresh soon after birth before their first feedings. Serum eosinic...
Abstract Background: Serum pro‐inflammatory cytokine levels are frequently elevated in the acute phase of pediatric inflammatory bowel disease (IBD). Because role IBD has not been well investigated, serum cytokines and expression Th1 Th2 signaling molecules mucosa from were examined. Methods: Twenty children with ulcerative colitis (UC; mean age, 9.95 ± 4.10 years) 12 Crohn's (CD; 10.0 4.90 enrolled for (interleukin [IL]‐4, IL‐5, IL‐6, tumor necrosis factor‐α, growth factor‐β1, interferon‐γ)...
Abstract Background Despite the presence of ganglion cells in rectum, some patients have symptoms similar to those Hirschsprung's disease. A consensus has yet be established regarding terminology for these diseases. We defined this group diseases as “allied disorders disease” and compiled guidelines facilitate accurate clinician diagnosis provide appropriate treatment strategies each Methods These were developed using methodologies Medical Information Network Distribution System ( MINDS )....
Abstract Background and Aim Serum leucine‐rich alpha‐2 glycoprotein (LRG) calprotectin have been studied as disease activity markers in adults with inflammatory bowel (IBD). We evaluated them pediatric IBD patients. Methods Subjects under 17 years old undergoing care at 11 Japanese centers were retrospectively assigned to 3 groups representing Crohn's (CD), ulcerative colitis (UC), normal controls (NC) irritable syndrome or no illness. LRG measured using commercial enzyme‐linked...
This study aimed to evaluate the effects of psychosocial and neurodevelopmental disorders on pediatric ulcerative colitis management. Specifically, relationships between these disease severity, as well treatment strategies, were assessed through a single-center, retrospective, observational study. The included patients with (UC) under 15 years age diagnosed by colonoscopy histological evaluation January 2022 May 2024. Data comorbid functional gastrointestinal obtained from patients'...
Abstract Background Very-early-onset ulcerative colitis (VEO-UC) is a severe form of inflammatory bowel disease that manifests before the age 6 years. Compared to typical pediatric UC, it characterized by distinct genetic and immunological factors. This study aimed investigate roles specific human leukocyte antigen (HLA) alleles maternal microchimerism (MMc) in pathogenesis VEO-UC Japanese population. Methods included 27 patients, including 4 patients treated with colorectal resection. HLA...
Objective. To assess anxiety among pediatric patients and their parents related to initial gastrointestinal endoscopy. Methods. Patients aged <19 years undergoing (GI) endoscopy were invited complete a self-administered questionnaire in 13 institutions Japan. Results. The subjects 128 children, 1 month 17 years. Forty-eight (37.5%) underwent esophagogastroduodenoscopy (EGD), 32 (25%) colonoscopy (CS), 39 (30.5%) both EGD CS, 3 (2.3%) balloon enteroscopy (BE), capsule (CE), CE other...
The aim of this study was to clarify the usefulness magnetic resonance cholangiopancreatography (MRCP) for evaluation choledochal cyst in children.MRCP performed preoperatively 33 patients. MRCP findings were compared with those endoscopic retrograde or intraoperative cholangiopancreatography.In all patients, could detect cyst. detection rate a main pancreatic duct 62.2%, abnormal union pancreaticobiliary junction (AUPBJ) 53.3%, dilatation abnormalities 75.0% and protein plug stone 76.9%. In...
Abstract Aim: Previous studies suggest the homeostasis between acquisition of tolerance to indigenous microflora and protective immune responses appears be disrupted in inflammatory bowel disease (IBD). Some experimental indicate peroxisome proliferator‐activated receptor γ (PPARγ) has been implicated as a regulator intestinal responses. In addition, toll‐like (TLR)‐4 can regulate expression PPARγ colonic epithelial cells. We attempted demonstrate whether functional imbalance TLRs could lead...
We provided psychological preparation to children who were hospitalized for endoscopy. performed a multifaceted evaluation of the effects identify appropriate methods individual children. The subjects 20 children, ages 4 15 years (average 9.9 years), divided into 3 groups according methods. From our study, we suggest that it is important discuss medical procedures using level cognitive development each child.
Abstract Background Although Helicobacter pylori infection among adults is a major risk factor for the development of gastric cancer and initial with H. may occur before 5 years age, direct effects since childhood on mucosa are unknown. The aim this study was to evaluate gene expression in ‐infected children. Methods Gastric mucosal samples were obtained from 24 patients (12 12 children) who had undergone endoscopic evaluation chronic abdominal complaints examined by adult pediatric...
ABSTRACT Citrobacter rodentium , a natural mouse pathogen, belongs to the family of extracellular enteric pathogens that includes enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. (EHEC). C. shares many virulence factors with EPEC EHEC relies on attaching-and-effacing lesion formation for colonization infection gut. In vivo, is characterized by increased epithelial cell proliferation, mucosal thickening, TH1-type immune response, but protective immunity believed be mediated...
Abstract Background Although rectal bleeding in infancy ( RBI ) is not a rare phenomenon, the clinical course of fully understood. Methods To investigate outcome and pathogenesis , especially when concomitant with food‐protein‐induced proctocolitis FPIP neonatal transient eosinophilic colitis NTEC ), 22 neonates from J anuary 2008 to une 2012 were enrolled their mechanisms inflammation examined. Results Thirteen infants showed after feeding diagnosed nine before . Elevated peripheral white...
We retrospectively determined the safety and efficacy of endoscopic delivery (ED) capsule endoscopes.We enrolled 10,156 patients who underwent small bowel endoscopy (SBCE), 3182 patency (PC), 1367 colon (CCE), at 11 gastroenterological nine pediatric centers.Small endoscopies, PCs, CCEs were endoscopically delivered to 546 (5.4%), 214 (6.7%), 14 (1.0%) patients, respectively. Only mild complications occurred for 21.6% (167/774), including uneventful mucosal damage, bleeding, abdominal pain....
This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) Japan, using real-world data, and aimed to establish genotype-based strategies.
6-Mercaptopurine (6-MP) and azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations Japanese IBD have not been reported.This retrospective review examines 32 ulcerative colitis (UC) patients 19 Crohn's (CD) (12.87 ± 3.56 years) who required 6-MP or AZA to maintain remission. All were treated for at least 3 weeks prior this study addition previous treatment. dose, 6-TGN levels,...
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated Citrobacter rodentium model colonic infection and inflammation Galectin-1 or Galectin-3 null mice. Gal-3 mice showed a slight delay colonisation after inoculation with C. resolution infection, associated delayed T cell, macrophage dendritic cell infiltration into mucosa. However, Gal-1 also demonstrated reduced responses to infection. response...