Hirotaka Sakaguchi

ORCID: 0009-0006-0722-5781
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About
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Research Areas
  • Radiation Detection and Scintillator Technologies
  • Luminescence Properties of Advanced Materials
  • Pediatric Hepatobiliary Diseases and Treatments
  • Inorganic Fluorides and Related Compounds
  • Atomic and Subatomic Physics Research
  • Nuclear materials and radiation effects
  • Microscopic Colitis
  • Diabetes and associated disorders
  • Urticaria and Related Conditions
  • Ga2O3 and related materials
  • Systemic Lupus Erythematosus Research
  • Neonatal Health and Biochemistry
  • Blood disorders and treatments
  • Optical and Acousto-Optic Technologies
  • Abdominal vascular conditions and treatments
  • Drug-Induced Adverse Reactions
  • Pregnancy and Medication Impact
  • Drug Transport and Resistance Mechanisms
  • Microwave Dielectric Ceramics Synthesis
  • Trace Elements in Health
  • Infectious Encephalopathies and Encephalitis
  • Gallbladder and Bile Duct Disorders
  • Gastroesophageal reflux and treatments
  • Congenital Anomalies and Fetal Surgery
  • Bacterial Infections and Vaccines

Nara Institute of Science and Technology
2022-2024

St Mary's Hospital
2023

Kurume University
2020-2022

Biliary atresia (BA) is among the commonest indications for liver transplantation (LT) in children. We examined whether serum matrix metalloproteinase-7 (MMP-7) useful diagnosis of BA Japanese infants, and MMP-7 concentrations before after Kasai portoenterostomy (KP) predicted LT within a year.Subjects under 6 months old at eight pediatric centers Japan were enrolled retrospectively, including patients with cholestasis normal controls (NC) without disease. Patients divided into groups...

10.1111/hepr.13753 article EN Hepatology Research 2022-02-02

Abstract We have investigated the photoluminescence (PL), scintillation, and photostimulated-luminescence (PSL) properties of Yb-doped SrCl 2 transparent ceramics. The samples were prepared using spark plasma sintering method. Emission peaks in PL, PSL spectra observed at 380 405 nm due to spin-allowed spin-forbidden 4f 13 5d 1 –4f 14 transitions Yb 2+ , respectively. PL quantum yield ( QY ) value elevated with increasing concentration 0.05%–1.0%, 1.0% ceramic indicated highest value. This...

10.35848/1347-4065/ad41ae article EN Japanese Journal of Applied Physics 2024-05-01

10.1016/j.nimb.2024.165244 article EN Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 2024-01-13

Immunoglobulin A vasculitis (IgAV) is a systemic small-vessel vasculitis. Although corticosteroids (CS) are the primary treatment for gastrointestinal manifestations associated with IgAV, some patients develop refractory or recurrent symptoms such as vomiting and abdominal pain despite CS treatment. Dapsone, synthetic sulfone antimicrobial, has been used to treat cutaneous purpura in but few authors have reported its use symptoms. In this retrospective observational study, we describe...

10.1542/peds.2021-055884 article EN PEDIATRICS 2022-08-17

Abstract Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis BA in Japanese children. Subjects under 6 months old at 7 pediatric centers Japan were prospectively enrolled, including patients with cholestasis and healthy controls (HC) without liver disease. Patients constituted 2 groups representing others from other causes (non-BA). We quantitatively...

10.1038/s41598-021-84445-w article EN cc-by Scientific Reports 2021-03-02

Diagnosing acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) after the first seizure (early seizure/seizures, ES/ESs) is challenging because a apparent coefficient (ADC) in cortical or subcortical white matter, often described as having "bright-tree appearance (BTA)," usually not observed until secondary (late seizures, LSs) occur. Previous studies have reported hypoperfusion on arterial spin labeling (ASL) within 24 h ES/ESs patients AESD hyperperfusion LS onset....

10.3389/fnins.2023.1252410 article EN cc-by Frontiers in Neuroscience 2023-09-19

Abstract Ischemic colitis (IC), the most common form of intestinal ischemia, ranges from superficial mucosal and submucosal injury to full‐thickness mural necrosis. As risk factors include cerebrovascular disease, hypertension, diabetes mellitus, prior abdominal surgery, irritable bowel syndrome, constipation, IC typically occurs in elderly persons with multiple comorbidities rather than young children. A 1‐year‐old Japanese girl receiving a stimulant laxative for constipation since age 7...

10.1002/jgh3.12361 article EN cc-by JGH Open 2020-05-25
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