A5088008401- Inflammatory Bowel Disease
- Microscopic Colitis
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
- Autoimmune and Inflammatory Disorders
- IL-33, ST2, and ILC Pathways
- Digestive system and related health
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- Diverticular Disease and Complications
- Eosinophilic Disorders and Syndromes
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Pavia
2016-2025
Policlinico San Matteo Fondazione
2015-2025
University Hospital Foundation
2019-2025
Bambino Gesù Children's Hospital
2023-2024
University of Palermo
2024
University of L'Aquila
1994-2023
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
A gut bacterial containment system Trillions of bacteria selectively inhabit our guts, but how do bodies keep them contained? Spadoni et al. describe a “gut-vascular barrier” that prevents intestinal microbes from accessing the liver and bloodstream in mice (see Perspective by Bouziat Jabri). Studies with human samples revealed cell biology gut-vascular barrier shares similarities blood-brain central nervous system. Pathogenic such as Salmonella typhimurium could penetrate mice, gaining...
Crohn's disease-related inflammation is characterized by reduced activity of the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels SMAD7, an inhibitor TGF-β1 signaling. Preclinical studies and a phase 1 study have shown that oral SMAD7 antisense oligonucleotide, mongersen, targets ileal colonic SMAD7.In double-blind, placebo-controlled, 2 trial, we evaluated efficacy mongersen for treatment persons with active disease. Patients were randomly assigned...
<h3>Background and Aims:</h3> Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production bowel disease (IBD) are still unclear. <h3>Methods:</h3> Endoscopic biopsies or surgical specimens were taken from inflamed uninflamed colonic mucosa 72 patients with IBD (38 Crohn’s 34 ulcerative colitis), normal colon 38 control subjects. IL17 interferon γ (IFNγ) detected by ELISA supernatants cultured ex vivo,...
This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focused on prediction, diagnosis, management fibrostenosing disease [CD]. The objective was to achieve evidence-supported, expert consensus that provides guidance for clinical practice.
OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic approaches for this population. RESEARCH DESIGN AND METHODS In a multicenter, case-control, retrospective, observational study, sitagliptin, an oral highly selective dipeptidyl peptidase 4 inhibitor, was added standard of care (e.g., insulin administration) at the time hospitalization who were hospitalized COVID-19. Every...
Up to 40% of patients with inflammatory bowel disease present psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination bacteria from intestine liver. Here, we describe in brain choroid plexus (PVB) is modulated response intestinal inflammation through bacteria-derived lipopolysaccharide. The induces PVB closure after opening by up-regulation wingless-type, catenin-beta 1 (Wnt/β-catenin) signaling pathway, rendering it inaccessible large...
Epithelium derived interleukin (IL)-15 signalling via IL-15Ralpha is critical for the development, activation, and survival of intraepithelial lymphocytes (IEL). We aimed to better understand IL-15 driven effects on IEL underlying mucosal damage lymphomagenesis in coeliac disease (CD).Enterocytes, IEL, lamina propria mononuclear cells (LPMC) were isolated from 46 patients with uncomplicated CD (25 untreated 21 treated) 22 controls. expression determined by immunoblotting. Secretion IL-15,...
Butyrate exerts anti-inflammatory effects in experimental colitis and on Crohn's disease lamina propria mononuclear cells vitro.To explore the efficacy safety of oral butyrate disease.Thirteen patients with mild-moderate ileocolonic received 4 g/day as enteric-coated tablets for 8 weeks. Full colonoscopy ileoscopy were performed before after treatment. Endoscopical histological score, laboratory data, activity index mucosal interleukin (IL)-1beta, IL-6, IL-12, interferon-gamma, tumour...
In addition to its crucial role in dampening tissue-damaging immune responses the gut, transforming growth factor beta (TGFbeta) is a potent profibrogenic agent inducing collagen synthesis and regulating balance between matrix-degrading matrix metalloproteinases (MMPs) their inhibitors (TIMPs). TGFbeta signalling was investigated by analysis of Smad proteins MMPs/TIMPs mucosa overlying strictures patients with Crohn's disease (CD).Specimens were collected from macroscopically normal...
To verify whether targeting defective mucosal T cell death underlies the sustained therapeutic benefit of infliximab in Crohn's disease, we explored its vivo proapoptotic effect after 10 weeks treatment, and vitro killing activity on lamina propria cells (LPT) peripheral blood (PBT), both isolated from disease patients.Endoscopic intestinal biopsies were collected patients (six steroid refractory four fistulising) before three consecutive infusions infliximab, administered at week 0, 2, 6 a...
Background Anemia is a common complication of inflammatory bowel disease, but its epidemiology may be changing due to earlier diagnosis and improved treatments. We investigated the prevalence pathogenesis anemia in patients with disease.Design Methods In cross-sectional study 263 out-patients disease (165 Crohn’s 98 ulcerative colitis) were investigated. The influence time from diagnosis, activity, inflammation status iron hematinic vitamins on level hemoglobin evaluated. second group 27...