A5090159512- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Hepatitis C virus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Hepatitis B Virus Studies
- Chronic Disease Management Strategies
- Employment and Welfare Studies
- Alcohol Consumption and Health Effects
- Immunodeficiency and Autoimmune Disorders
- Diabetes Treatment and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Studies
- Leprosy Research and Treatment
- Biosimilars and Bioanalytical Methods
Azienda Sanitaria Locale di Asti
2024-2025
University College London
2021-2024
Royal Free London NHS Foundation Trust
2019-2024
The Royal Free Hospital
2021-2022
University of Pavia
2017-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2022
Policlinico San Matteo Fondazione
2018-2021
Roland Hill (United Kingdom)
2021
Zayed University
2021
Institute for Liver Health
2019
Summary Background Autoimmune atrophic gastritis (AAG) is characterised by a wide clinical spectrum that could delay its diagnosis. Aims To quantify the diagnostic in patients suffering from AAG and to explore possible risk factors for longer delay. Methods Consecutive with evaluated at our gastroenterological outpatient clinic between 2009 2018 were included. Diagnostic was estimated as time lapse occurring appearance of first likely symptoms, laboratory alterations, other clues indicative...
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function 100 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit March 2020. retrospectively assessed tests, taking into account demographic characteristics and outcome. A patient was considered as having injury when alanine aminotransferase (ALT) > 50 mU/ml, gamma-glutamyl...
Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed assess patterns of anaemia and micronutrient deficiencies in patients AAG at time diagnosis.Observational, multicentre, cross-sectional study including consecutive adult diagnosed within last ten years. Cell blood count, red cell distribution width, serum B12, ferritin were collected. Multivariate...
Despite intravenous (IV) vedolizumab being established for treatment of inflammatory bowel disease (IBD), the novel subcutaneous (SC) route administration may provide numerous incentives to switch. However, large-scale real-world data regarding long-term safety and effectiveness this strategy are lacking.
Background Many liver patients have unmet palliative care needs, but clinicians are unclear whom to refer specialist (SPC). The Supportive and Palliative Care Indicator Tool (SPICT) the Bristol Prognostic Screening (BPST) could help identify suitable patients, neither has been tested for this role. This study evaluated their role as screening tools needs predicting 12-month mortality. Methods A case note review of hepatology in-patients, who were not peritransplant post-transplant status,...
Objectives Twenty per cent of people with alcohol use disorders develop advanced fibrosis and warrant referral to secondary care. Improving outcomes in alcohol-related liver disease (ArLD) relies on its earlier detection primary care non-invasive tests (NIT). We aimed determine the proportion referrals who were diagnosed care, prevalence both fatty (‘BAFLD’) potential impact NIT stratification. Design/setting Retrospective analysis all general practitioner-referrals suspected...
Abstract Background and aims Alcohol use disorders (AUD) cause 7.2% of UK hospital admissions/year. Most are not managed by hepatologists liver disease may be missed. We used the Enhanced Liver Fibrosis (ELF) test to investigate prevalence associations occult advanced fibrosis in AUD patients known have fibrosis. Methods was assessed using ELF prospective referred Royal Free Hospital Specialist Nurse (November 2018–December 2019). Known cases were excluded. Patient demographics, blood tests,...
Introduction Although percutaneous endoscopic gastrostomy with jejunal extension (PEG-J) is currently indicated in a variety of conditions, limited data are available regarding its safety and the best timing for replacement. We herein describe single-centre cohort patients who underwent PEG-J placement or replacement to assess short- long-term procedure.Methods Demographic procedure-related all undergoing procedure between March 2010 2020, either first any replacement, at Endoscopy Unit...
<b><i>Introduction:</i></b> The Multidimensional Prognostic Index (MPI) is a validated tool for assessing mortality risk in hospitalised patients. We aimed to evaluate whether the MPI predicted and of developing diverticular disease (DD) complications older <b><i>Methods:</i></b> This multicentre study conducted January 2016-March 2018. All patients with DD aged 65 years were included. Patients stratified into three groups according (1, low...
Stigmatization is the separation of an individual from a group due to aspects that make them different. Resilience may in turn influence perception stigma. Patients with inflammatory bowel disease (IBD) are susceptible stigma, although data very limited.To validate Italian translation IBD perceived stigma scale (PSS) relation patients' resilience.Consecutive outpatients were prospectively enrolled (December 2018-September 2019) Italian, tertiary referral, center. Clinical and demographic...
Abstract Background The natural history and incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions are not well described. We aimed to define the HCC in a cohort patients undergoing surveillance by magnetic resonance imaging (MRI) estimate any associations with incident HCC. Methods performed retrospective follow-up study, identifying MRI scans which had been reported between January 2006 2017. Subsequent scan reports were reviewed for lesions, data extracted...
ABSTRACT Despite the availability of effective treatment and vaccines for hepatitis B virus (HBV) C (HCV), many people are still infected remain unaware their infection. The Camden Islington Viral Hepatitis Identification Tool (CIVHIT), a computer‐based search tool, was introduced in 60 general practices (GPs) April 2014 to support identification, testing individuals at high risk blood‐borne viruses (BBVs). CIVHIT searched electronic medical records (EMRs), flagging all those with codes...
Abstract Background Vedolizumab, a gut-selective monoclonal antibody targeting α4β7-integrin, was recently licenced as subcutaneous (SC) preparation after demonstrating efficacy compared to placebo at maintaining remission in IBD patients who had clinical response intravenous (IV) induction therapy. We aimed assess real-world experience of switching SC administration. Methods Patients across 10 UK centres completed with IV vedolizumab were offered Demographic data and baseline disease...