A5046704362- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Hepatitis C virus research
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Clinical practice guidelines implementation
- Hematopoietic Stem Cell Transplantation
- Ovarian cancer diagnosis and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Asthma and respiratory diseases
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Sarcoma Diagnosis and Treatment
- Enhanced Recovery After Surgery
Piedmont Reference Center for Epidemiology and Cancer Prevention
2016-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2016-2025
Barcelona Institute for Science and Technology
2025
Institute for Bioengineering of Catalonia
2025
University of Glasgow
2025
University of Turin
2011-2023
Areté Associates (United States)
2023
GlaxoSmithKline (India)
2022
Clovis Oncology (United Kingdom)
2022
Collaborative Group (United States)
2022
This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and lenalidomide maintenance therapy no in patients newly diagnosed multiple myeloma.We randomly assigned 273 65 years age or younger to high-dose MPR consolidation after induction, 251 therapy. The primary end point was progression-free survival.The median follow-up period 51.2 months. Both...
In this trial of the treatment newly diagnosed multiple myeloma, we compared a protocol that entailed hematopoietic stem-cell autograft followed by an allograft from HLA-identical sibling with tandem autografts.We enrolled 162 consecutive patients myeloma who were 65 years age or younger and had at least one sibling. All initially treated vincristine, doxorubicin, dexamethasone, melphalan autologous rescue. Patients then received nonmyeloablative total-body irradiation stem cells without two...
Tracheotomy is used to replace endotracheal intubation in patients requiring prolonged ventilation; however, there considerable variability the time considered optimal for performing tracheotomy. This of clinical importance because timing a key criterion tracheotomy and who receive one require large amount health care resources.To determine effectiveness early (after 6-8 days laryngeal intubation) compared with late 13-15 reducing incidence pneumonia increasing number ventilator-free...
Purpose The combination of bortezomib-melphalan-prednisone (VMP) is a new standard care for newly diagnosed multiple myeloma. This phase III study examined the efficacy four-drug bortezomib-melphalan-prednisone-thalidomide (VMPT) followed by maintenance with bortezomib-thalidomide (VMPT-VT) compared VMP treatment alone in untreated myeloma patients who are ineligible autologous stem-cell transplantation. Patients and Methods A total 511 were randomly assigned to receive nine cycles VMPT...
Lenalidomide has shown significant antimyeloma activity in clinical studies. Oral melphalan, prednisone, and thalidomide have been regarded as the standard of care elderly multiple myeloma patients. We assessed dosing, efficacy, safety lenalidomide (MPR) newly diagnosed patients.Oral melphalan was administered doses ranging from 0.18 to 0.25 mg/kg on days 1 4, prednisone at a 2-mg/kg dose 5 10 mg 21, every 28 for nine cycles, followed by maintenance therapy with alone. Aspirin given...
Objective. To compare percutaneous ethanol injection (PEI), the standard approach which has been used for many years to treat early non-surgical hepatocellular carcinoma (HCC) in cirrhotic patients, and radiofrequency ablation (RFA), become an interesting alternative. Material methods. A randomized trial was carried out on 139 patients Child-Pugh classes A/B with 1–3 nodes of HCC (diameter 15–30 mm), a total 177 lesions. Patients were receive RFA (n=70) or PEI (n=69). The primary end-point...
OBJECTIVES: To investigate the relation between traffic indicators in area of residence and occurrence chronic respiratory disorders children. METHODS: A population based survey was conducted 10 areas northern central Italy (autumn 1994 to winter 1995) two age groups (6-7 13-14 years). Information on several near residences collected with a questionnaire given children their parents. The sample analysed included 39,275 subjects (response rate 94.4%). Outcomes were: (a) early (first 2 years...
Wheezing in childhood is not a single disorder and different wheezing-associated respiratory illnesses have been recently described. We investigated the association between wheezing conditions familial, pre-, peri-, postnatal risk factors. studied 16,333 children, 6 to 7 yr old, enrolled population-based study. Standardized questionnaires were filled by parents. A total of 1,221 children had transient early wheezing, 671 persistent 918 late-onset 13,523 never or asthma (control group)....
BACKGROUND. Several studies conducted during the 1990s indicated an increase in prevalence of symptoms asthma; more recent investigations suggest that trend is stabilizing or may even be reversing. OBJECTIVE. We compared 2 cross-sectional surveys 1994 and 2002 8 areas northern central Italy, to evaluate changes for asthma, allergic rhinitis, eczema. METHODS. The International Study Asthma Allergies Childhood methods questionnaires were used investigate 6- 7-year-old children (16115 11287...
Smokers are characterized by a low-grade systemic inflammatory state and an oxidant-antioxidant imbalance. Few human studies were conducted on the effects of resveratrol, natural compound with anti-inflammatory antioxidant properties, no trial smokers has been performed to date. We evaluated whether resveratrol beneficial markers inflammation oxidative stress in smokers.A randomized, double- blind, cross-over was 50 healthy adult smokers: 25 randomly allocated "resveratrol-first" (30-days:...
Survival rates among childhood cancer survivors (CCS) have enormously increased in the last 40 years. However, this improvement has been achieved at expense of serious late effects that frequently involve endocrine system.To evaluate cumulative incidence diseases a cohort long-term CCS.We analyzed clinical data 310 adults, followed for median time 16.0 years after first diagnosis. The monitoring protocols applied to each patient were personalized on basis diagnosis and previous treatments,...
Purpose Continuous therapy (CT) prolongs progression-free survival 1 (PFS1; time from random assignment until the first progression or death), but chemotherapy-resistant relapse may negatively impact overall (OS). Progression-free 2 (PFS2; second death) represent an additional tool to estimate outcome. This study evaluates benefit of novel agent–based CT versus fixed duration (FDT) in patients with newly diagnosed myeloma. Methods We included enrolled onto three phase III trials that...
Purpose The clinical impact of positron emission tomography (PET) evaluation performed early during first-line therapy in patients with advanced-stage Hodgkin lymphoma, terms providing a rationale to shift who respond poorly onto more intensive regimen (PET response-adapted therapy), remains be confirmed. Patients and Methods phase II part the multicenter HD0801 study involved 519 de novo lymphoma received an initial treatment doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) underwent...