A5022045437- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Diet and metabolism studies
- Historical and Environmental Studies
- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diverse academic and cultural studies
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Urban Planning and Valuation
- Pancreatic function and diabetes
- Hepatitis C virus research
- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Alcohol Consumption and Health Effects
- Hemoglobinopathies and Related Disorders
- Endoplasmic Reticulum Stress and Disease
- Urban Planning and Landscape Design
- Folate and B Vitamins Research
- Marine Biology and Environmental Chemistry
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
University of Turin
2015-2024
Ospedale Humanitas Gradenigo
2009-2017
Istituto di Fisiologia Clinica
2014
Regione Piemonte
2010
National Research Council
1982-2009
The University of Queensland
2009
Fondazione Ricerca Molinette
1996-2008
Azienda Ospedaliero Universitaria San Giovanni Battista
1996-2008
University of Padua
2003
Ospedale Microcitemico
2003
This study aims to determine the presence of components metabolic syndrome in primary nonalcoholic steatohepatitis (NASH) and assess role liver disease genesis peripheral hyperinsulinemia. Nineteen patients (18 men 1 woman; mean age, +/- SD, 38 10 years; body mass index [BMI], 26 2 kg/m(2)) with histologic evidence NASH were enrolled; 19 age- sex-matched normal subjects investigated as controls. Plasma glucose, insulin, C-peptide levels measured during an oral glucose tolerance test, a...
Nonalcoholic fatty liver disease (NAFLD) encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). NAFLD carries higher risk of cardio-metabolic and liver-related complications, the latter being confined NASH demanding specific treatment. We assessed efficacy proposed treatments for NAFLD/NASH by reviewing reports randomized controlled trials (RCTs) on online databases national international meeting abstracts through January 2010. Primary...
Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased nonalcoholic fatty liver disease (NAFLD); however, if this is due to muscular protein catabolism, obesity, and/or insulin resistance (IR) or impaired tissue metabolism unknown. Thus, we evaluated a) subjects with NAFLD without obesity (NAFLD‐NO) compared those (NAFLD‐Ob) display altered plasma controls (CTs); and b) AA associated IR histology. Glutamic acid, serine, glycine known...
Gestational diabetes mellitus (GDM), a common pregnancy complication, is associated with an increased risk of maternal/perinatal outcomes. We performed prospective observational explorative study in 41 GDM patients to evaluate their microbiota changes during and the associations between gut variations nutrient intakes, anthropometric laboratory variables. routinely received nutritional recommendations according guidelines. The fecal (by 16S amplicon-based sequencing), was assessed at...
Abstract Circulating levels of four adipokines (adiponectin, TNF-α, leptin, and resistin) the postprandial lipid adiponectin responses to an oral fat load were assessed in 25 non-obese, non-diabetic patients with biopsy-proven nonalcoholic steatohepatitis (NASH) correlated metabolic indices liver histology. was lower NASH compared controls (5,476 ± 344 vs. 11,548 836 ng/mL; P = .00001) on multiple regression analysis negatively steatosis, necroinflammation (OR 5.0; .009), fibrosis 8.0;...
The ability of the Adult Treatment Panel III (ATP III) criteria metabolic syndrome to identify insulin-resistant subjects at increased cardiovascular risk is suboptimal, especially in absence obesity and diabetes. Nonalcoholic fatty liver disease (NAFLD) associated with insulin resistance emerging as an independent factor. We compared strength associations ATP NAFLD resistance, oxidative stress, endothelial dysfunction nonobese nondiabetic subjects.Homeostasis model assessment (HOMA-IR) >2,...
The relationships between the adipokines tumor necrosis factor (TNF)-alpha and adiponectin parameters of glucose homeostasis severity liver disease were assessed in nonobese nondiabetic subjects with nonalcoholic steatohepatitis (NASH).A frequently sampled intravenous tolerance test, serum cytokine measurement, 7-day alimentary record performed 20 biopsy-proven NASH patients 45 age-, sex-, BMI-matched controls (30 insulin sensitive 15 resistant).Patients had impaired pancreatic beta-cell...
Smokers are characterized by a low-grade systemic inflammatory state and an oxidant-antioxidant imbalance. Few human studies were conducted on the effects of resveratrol, natural compound with anti-inflammatory antioxidant properties, no trial smokers has been performed to date. We evaluated whether resveratrol beneficial markers inflammation oxidative stress in smokers.A randomized, double- blind, cross-over was 50 healthy adult smokers: 25 randomly allocated "resveratrol-first" (30-days:...
Abstract Chronic hepatitis C (CHC) has been associated with type 2 diabetes and insulin resistance, but the extent of impairment in action, target pathways involved, role virus per se have not defined. In this study, we performed a euglycemic hyperinsulinemic clamp (1 mU · minute −1 kg ) coupled infusion tracers ([6,6- H ]glucose, [ 5 ]glycerol) indirect calorimetry 14 patients biopsy-proven CHC, who were selected to any features metabolic syndrome, seven healthy controls. We also measured...
Background/Objectives It has been hypothesized that assuming most of the caloric intake later in day leads to metabolic disadvantages, but few studies are available on this topic. Aim our study was prospectively examine whether eating more daily at dinner an increased risk obesity, hyperglycemia, syndrome, and non-alcoholic fatty liver disease (NAFLD). Subjects/Methods 1245 non-obese, non-diabetic middle-aged adults from a population-based cohort underwent 3-day food record questionnaire...