A5082496371- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Adrenal and Paraganglionic Tumors
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Amyotrophic Lateral Sclerosis Research
- Organ Donation and Transplantation
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Parkinson's Disease Mechanisms and Treatments
- Chronic Lymphocytic Leukemia Research
- Graphite, nuclear technology, radiation studies
- COVID-19 and healthcare impacts
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Myasthenia Gravis and Thymoma
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2015-2025
Azienda Ospedaliero Universitaria Maggiore della Carita
2012-2025
Azienda Ospedaliera Ospedale Maggiore
2007-2023
University of Rome Tor Vergata
2021
Copenhagen University Hospital
2018
Rigshospitalet
2018
Sahlgrenska University Hospital
2018
Ospedale Maggiore
1995
Purpose The clinical impact of positron emission tomography (PET) evaluation performed early during first-line therapy in patients with advanced-stage Hodgkin lymphoma, terms providing a rationale to shift who respond poorly onto more intensive regimen (PET response-adapted therapy), remains be confirmed. Patients and Methods phase II part the multicenter HD0801 study involved 519 de novo lymphoma received an initial treatment doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) underwent...
Imaging of cardiac <sup>18</sup>F-FDG uptake is used in the diagnostic evaluation residual viable myocardium. Although, originally, hibernating myocardium was identified by a mismatch between perfusion defect and relatively preserved uptake, at present several studies propose that distribution can also be alone for this purpose. Nevertheless, even severe myocardial defects are frequently observed cancer patients without any disease. The aim study to retrospectively analyze global regional...
Sarcopenia is a skeletal muscle disorder characterized by reduced mass, strength, and performance. Muscle ultrasound can be helpful in assessing quality, architecture, thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate the reliability assessment tibialis anterior sarcopenia diagnosis. We included subjects undergoing total partial hip replacement, comparing measures with healthy control group. measured following parameters: thickness,...
Abstract The role of consolidation radiotherapy (RT) for bulky lesions is controversial in patients with advanced-stage Hodgkin lymphoma who achieve complete metabolic response (CMR) after doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD)–based chemotherapy. We present the final results Fondazione Italiana Linfomi HD0801 trial, which investigated potential benefit RT that setting. In this phase 3 randomized study, a lesion at baseline (a mass largest diameter ≥5 cm) have CMR 2 and 6...
This study analyzed the genetics of classical Hodgkin lymphoma (cHL) by using circulating tumor DNA (ctDNA). Two genetic subtypes were identified, differing in instability mechanisms: one subtype (64% cases) showed a higher mutation load and fraction mutations associated with activation-induced cytidine deaminase microsatellite signatures, while other (36% exhibited chromosomal more somatic copy number alterations. Whole-genome duplication was common cHL compared to B-cell tumors emerged as...
The diagnosis of amyotrophic lateral sclerosis (ALS) is primarily clinical, supported by the electromyographic examination to reveal signs lower motor neuron damage. Identifying reliable markers upper (UMN) involvement challenging. On this regard, role transcranial magnetic stimulation-induced motor-evoked potentials (TMS-MEPs), and its relationship with UMN burden, still under investigation. To evaluate ability TMS-MEPs in delineating neurophysiological damage, determine between...
Background. The purpose of this study was to compare the accuracy whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) that (18)F-FDG-PET/CT in staging patients primary gastrointestinal lymphoma. Methods. This retrospective involved 17 untreated abdominal All underwent and WB-DW-MRI. Histopathology findings or at least 6 months clinical radiological follow-up gold standard. Musshoff-modified Ann Arbor system used for staging, diagnostic evaluated on a per-node basis. Results....
[18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role esophageal cancer still debated. The aim of this study was to evaluate the semiquantitative baseline PET parameters as possible prognostic predictive factors a series carcinomas treated with combined modalities.43 patients carcinoma were chemoradiotherapy (CRT) followed by surgery 20 cases...
Abstract Background Time-of-flight (TOF) PET technology determines a reduction in the noise and improves reconstructed image quality low count acquisitions, such as overweight patients, allowing of administered activity and/or imaging time. However, international guidelines recommendations on 18 F-fluoro-2-deoxyglucose (FDG) administration scheme are old or only partially account for TOF advanced reconstruction modalities. The aim this study was to optimize FDG whole-body studies TOF-PET/CT...
We describe a 64-year-old woman, suffering from late-onset obsessive–compulsive disorder (OCD) the age of 57, who developed dysarthria and dysphagia, spastic diplegic, proximal muscles weakness. Needle electromyography showed no active denervation. Neuropsychological evaluation intact cognitive functioning. diagnosed upper motor neuron disease (MND), with known genetic correlates. Brain magnetic resonance (MRI) detected bilateral hippocampal atrophy sclerosis right hippocampus. 18F-FDG...
The ALS diagnosis requires an integrative approach, combining the clinical examination and supporting tests. Nevertheless, in several cases, proves to be suboptimal, for this reason, new diagnostic methods novel biomarkers are catching on. 18F-fluorodeoxyglucose (18F-FDG)-PET could a helpful method, but it still additional research sensitivity specificity. We performed 18F-FDG-PET single-subject analysis sample of familial patients carrying different gene mutations, investigating...
1024 Background: Estrogen receptors (ER) are considered predictive biomarkers to identify ER+ MBC patients who would likely benefit from endocrine therapies (ET). However, 30 40% of fail achieve a durable response. 18F-FES PET/CT has been shown represent valuable and accurate diagnostic tool determine ER status at the level metastatic sites can be proposed as valid alternative biopsy lesions. In this trial, we evaluated for responsiveness in MBC. Methods: ET-FES is an international,...
Background: Introduced in the latest BCLC 2022, endovascular trans-arterial radioembolization (TARE) has an important role treatment of unresectable hepatocellular carcinoma (HCC) as a "bridge" or "downstaging" disease. The evolution TARE technology allows more flexible and personalized target treatment, based on anatomy vascular characteristics each HCC. flex-dose delivery program is part this perspective, which us to adjust dose its radio-embolizing power relation size type cancer split...