A5084913991- Renal and related cancers
- Glioma Diagnosis and Treatment
- Resilience and Mental Health
- Mental Health via Writing
- Palliative Care and End-of-Life Issues
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Zebrafish Biomedical Research Applications
- Acute Lymphoblastic Leukemia research
- Family and Patient Care in Intensive Care Units
- Identity, Memory, and Therapy
- Thyroid Disorders and Treatments
- Innovations in Medical Education
- Phagocytosis and Immune Regulation
- Healthcare professionals’ stress and burnout
- Cancer Genomics and Diagnostics
- Health, psychology, and well-being
- Empathy and Medical Education
- COVID-19 and Mental Health
- Erythrocyte Function and Pathophysiology
- Fish Ecology and Management Studies
- Optimism, Hope, and Well-being
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Art Therapy and Mental Health
University of Parma
2016-2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2023-2024
University Children's Hospital Zurich
2020-2022
University of Catania
1984-2021
Sapienza University of Rome
2016-2021
University of Zurich
2016-2020
Ospedale Santa Maria Goretti
2020
Ri.MED
2018
Oxford University Press (United Kingdom)
2015
University of Pittsburgh
2010-2012
Abstract Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms and its derivative ONC206 have not been fully described Methods DMG models including primary human vitro (n = 18) vivo (murine zebrafish) models, patient 20) frozen FFPE specimens were used. Drug-target engagement was evaluated using silico ChemPLP thermal shift assay. Drug toxicity...
At present, there are no effective therapies to ameliorate injury, accelerate recovery, or prevent postinjury fibrosis after AKI. Here, we sought identify candidate compounds that recovery AKI by screening for small molecules increase proliferation of renal progenitor cells in zebrafish embryos. One compound identified from this screen was the histone deacetylase inhibitor methyl-4-(phenylthio)butanoate, which subsequently administered larvae and mice 24-48 hours inducing In zebrafish,...
Abstract Multigene delivery and subsequent cellular expression is emerging as a key technology required in diverse research fields including, synthetic structural biology, reprogramming functional pharmaceutical screening. Current viral systems such retro- adenoviruses suffer from limited DNA cargo capacity, thus impeding unrestricted multigene expression. We developed MultiPrime, modular, non-cytotoxic, non-integrating, baculovirus-based vector system expediting highly efficient transient...
One of the first hallmarks kidney regeneration is reactivation genes normally required during organogenesis. Identification chemicals with potential to enhance this could therapeutically promote regeneration. Here, we found that 4-(phenylthio)butanoic acid (PTBA) expanded expression domains molecular markers organogenesis in zebrafish. PTBA exhibits structural and functional similarity histone deacetylase (HDAC) inhibitors 4-phenylbutanoic trichostatin A; treatment these HDAC also renal...
In this video article we describe a zebrafish model of AKI using gentamicin as the nephrotoxicant. The technique consists intravenous microinjections on 2 dpf zebrafish. This represents an efficient and rapid method to deliver soluble substances into bloodstream larvae, allowing for injection 15-20 fish per hour. addition studies, microinjection can also be used other types experimental studies such angiography. We provide detailed protocol from equipment required visual measures decreased...
Clinical learning placements provide a real-world context where nursing students can acquire clinical skills and the attitudes that are hallmark of profession. Nonetheless, often report dissatisfaction with their placements. The aim this study was to test model relationship between student's perceived respect, role uncertainty, staff support, satisfaction practice.A cross-sectional, descriptive survey completed by 278 second- third-year undergraduate students. Specifically, we tested...
In the vertebrate embryo, kidney is derived from intermediate mesoderm. The LIM-class homeobox transcription factor lhx1 expressed early in mesoderm and one of first genes to be nephric mesenchyme. this study, we investigated role Lhx1 specification field by either overexpressing or depleting Xenopus embryos an explant culture system. By a constitutively-active form Lhx1, established its capacity expand during stage organogenesis. addition, ability diminishes as organogenesis transitions...
BACKGROUND AND AIM OF THE WORK: The main purpose of the study is to investigate experience nurses who worked in Covid-19 area focusing on perception their role. In particular, has been explored nurses' job satisfaction relation images sent back by public opinion through mass media and social communication channels. During first wave have acquired visibility , but feeling represented more discomfort finding themselves suddenly glorified face a lack professional, social, economic recognition....
Inter- professional Collaboration (IPC) is an important component of a well-functioning healthcare system. It linked to improvements in patient safety and case management, optimal use the skills each team member provision better health services. Education (IPE), one key factor development positive behaviors useful for IPC: basic post-basic training are moments raise awareness, train help implement IPC. Aim this paper present evaluate innovative laboratory Consensus Conference implemented...
The care of chronically ill and older adults affects families in terms physical, emotional, relational, social impact; the functioning family; an alteration family dynamics. This study aimed to evaluate experiences caregivers patients depth. A qualitative was conducted, consisting twenty-four narrative interviews with adults, twenty-three women one man. were all close relatives patients. main results as follows: (i) caregiving is predominantly performed by females; (ii) caregiver ‘indirect’...
The principal goal of this study is to describe the relevance typical autonomic patterns response in accordance a number psychopathological syndromes for an accurate multi-dimensional assessment.A sample 89 subjects was subdivided five pathological groups with clinical diagnosis following diagnostic criteria DSM V [1]: Generalized Anxiety Disorder (GAD), Panic Attack Disorders (PAD), Major Depressive Episodes (MDE), Obsessive Compulsive (OCD), Anorexia Nervosa (AN) and Healthy control group....
Uroplakin (UP)3a is critical for urinary tract development and function; however, its role in these processes unknown. We examined the function of UP3a-like protein Upk3l, which was expressed at apical surfaces epithelial cells that line pronephric tubules (PTs) zebrafish pronephros. Embryos treated with upk3l-targeted morpholinos showed decreased pronephros function, attributed to defects PT cell morphogenesis polarization including: loss an brush border associated phospho-ERM proteins,...
Numerous studies in the international literature hold that expressive writing is a useful tool to take care of person as whole. It gives voice emotions, moods and intimate thoughts patients, well caregivers family members. The reference model based on Pennebaker's theory (2004), which posits expressing our deeper feelings can result significant health benefits short long term. Studies over past 25 years have shown writing, is, simple emotional sensations, alleviate both physical...
If it is true that the impact of symptoms disease differently perceived by each person and there an incommunicability experiences suffering, equally narration provides understandable representation, which derives from network representations are part a personal history. The aim this study was to offer in-depth analysis "narrative interview" collected during assessment 74 years old diabetic woman.A case conducted nurse with advanced expertise in conducting narrative interview. Content Meaning...
Abstract The N13 component of somatosensory evoked potential (N13 SEP) represents the segmental response dorsal horn neurons. In this neurophysiological study, we aimed to verify whether SEP might reflect excitability changes neurons during central sensitization. 22 healthy participants, investigated how sensitization induced by application topical capsaicin ulnar nerve territory hand dorsum modulated elicited stimulation. Using a double-blind placebo-controlled crossover design, also tested...
Intensive Care Units are emotionally intense environments where professional autonomy and interprofessional collaboration essential. Nurses at high risk of burnout, the level compassion satisfaction has a deep impact on quality their life. Although leadership styles burnout have been subject an extensive body research, there is existing gap regarding relationship between strategies intensive care nurses' working life satisfaction. Specifically, lack literature in southern European countries...
In this video article we describe a zebrafish model of AKI using gentamicin as the nephrotoxicant. The technique consists intravenous microinjections on 2 dpf zebrafish. This represents an efficient and rapid method to deliver soluble substances into bloodstream larvae, allowing for injection 15-20 fish per hour. addition studies, microinjection can also be used other types experimental studies such angiography. We provide detailed protocol from equipment required visual measures decreased...
A patient is described who had a choriocarcinoma of the colon and, associated with it, gynecomastia and hyperthyroidism. Serum levels estrogens, thyroxine gonadotropin were elevated. circulating thyroid-stimulating activity equivalent to 0.577 (0.328–1.06) mU/ml bTSH was detected by McKenzie mouse bioassay. In this system, thepatient's plasma elicited duration action longer than that pituitary TSH andshorter LATS. Incubation antibovine-TSH antiserum inhibited 2-hr response significantly, but...