Christian P. Selinger
A5076631930- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Health Systems, Economic Evaluations, Quality of Life
- Gastrointestinal motility and disorders
- Biosimilars and Bioanalytical Methods
- Pharmaceutical studies and practices
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Adolescent and Pediatric Healthcare
- Anorectal Disease Treatments and Outcomes
- COVID-19 and healthcare impacts
- Esophageal and GI Pathology
- SARS-CoV-2 and COVID-19 Research
- Healthcare cost, quality, practices
- Clostridium difficile and Clostridium perfringens research
- Medication Adherence and Compliance
- Endometriosis Research and Treatment
- Diagnosis and treatment of tuberculosis
Leeds Teaching Hospitals NHS Trust
2016-2025
St James's University Hospital
2016-2025
University of Leeds
2016-2025
Université de Montpellier
2023-2025
Institut de Recherche pour le Développement
2022-2025
Centre National de la Recherche Scientifique
2022-2025
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2022-2025
Swiss Tropical and Public Health Institute
2023-2024
University of Bradford
2024
Concord Repatriation General Hospital
2011-2021
Background & AimsAnti–tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce formation of anti-drug antibodies. The ability to identify patients at increased risk development antibodies would facilitate selection therapy and use preventative strategies.MethodsWe performed a genome-wide association study variants associated with time in discovery cohort 1240 biologic-naïve Crohn's disease...
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be to protect our patients clinical services they rely on. This a novel coronavirus; much unknown as how it will affect people with IBD. We also lack information about impact different immunosuppressive medications....
Inflammatory bowel disease has a high incidence and prevalence especially in young individuals their reproductive years. Trying to conceive being pregnant is an emotional period for those involved. In the majority of patients suffering from inflammatory disease, maintenance therapy required during pregnancy control might necessitate introduction new drugs vulnerable period. Therefore, management with wish requires specialized counselling appropriate including multidisciplinary approach close...
Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination increase the risk of serious respiratory infections. We sought to determine whether infliximab-treated patients with IBD have attenuated serological responses SARS-CoV-2 infections.Antibody in participants treated infliximab were compared a reference cohort vedolizumab, gut-selective anti-integrin α4β7 monoclonal antibody that is not associated impaired...
BackgroundWe sought to report the effectiveness of infliximab and adalimumab over first 3 years treatment define factors that predict anti-TNF failure strategies prevent or mitigate loss response.MethodsPersonalised Anti-TNF therapy in Crohn's disease (PANTS) is a UK-wide, multicentre, prospective observational cohort study reporting rates anti-TNF-naive patients with active luminal aged 6 older. At end year, sites were invited enrol participants still receiving drug into 2-year...
Enabling women with inflammatory bowel diseases (IBD) to have successful pregnancies requires complex decisions. The study aimed assess patients' views on IBD and pregnancy evaluate any association subject knowledge.General attitudes of females were assessed fertility, medication use, delivery mode outcomes. Attitudes regarding personal situation in participants nulliparous since diagnosis. Knowledge pregnancy-related issues was by the Crohn's Colitis Pregnancy Score 'CCPKnow'.Of 145 68%...
Poor adherence frequently impaired the efficacy of therapy to maintain remission from inflammatory bowel diseases (IBD). There is a lack practical and effective interventions improve adherence. This study aimed identify modifiable risk factors, which may yield targets for new interventions.Participants with IBD were recruited hospital outpatient clinics office-based gastroenterologists. Demographic disease-related data recorded by means self-administered questionnaires. Modifiable factors...
Inflammatory Bowel Disease (IBD) affects many women of childbearing age, and rates voluntary childlessness (VC) exceed those the general population by far. The factors surrounding VC remain incompletely understood. Female members patient organisation Crohn's Colitis UK aged 18–45 years were invited to complete an online questionnaire collecting data on demographics, disease characteristics, pregnancy-specific disease-related knowledge (CCPKnow), status. A total 1324 (mean age 33 years)...
Summary Background Smoking demonstrates divergent effects in Crohn's disease ( CD ) and ulcerative colitis UC ). frequency is greater deleterious to its course. Conversely, primarily a of nonsmokers ex‐smokers, with reports amelioration active smoking. Aim To determine the prevalence smoking on progression surgery well‐characterised cohort inflammatory bowel diseases IBD patients. Methods Patients data Sydney Cohort were included. Demographic, phenotypic, medical, surgical hospitalisation...
Summary Background Inflammatory bowel diseases ( IBD ) require complex therapeutic decisions and life choices concerning pregnancy, but little is known about patient's knowledge of its treatment before during pregnancy. Aim To develop a novel tool (Crohn's Colitis Pregnancy Knowledge Score ‘ CCPKnow ’) to assess pregnancy‐related issues in . The validated was then applied determine patients. Method Discriminate ability ’ four groups with different levels knowledge. Reliability readability...
Summary Background Corticosteroids are central to inducing remission in inflammatory bowel disease ( IBD ) but ineffective maintenance agents. Aim To benchmark steroid usage British outpatients and assess factors associated with excess exposure. Methods We recorded use unselected outpatients. Cases meeting criteria for dependency or were blind peer reviewed determine whether prescriptions avoidable. Associations between patient/institutional analysed. Results Of 1176 patients, 30% received...