A5115598297- Inflammatory Bowel Disease
- Advanced Chemical Sensor Technologies
- Gut microbiota and health
- Microscopic Colitis
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Autoimmune and Inflammatory Disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Probiotics and Fermented Foods
- Analytical Chemistry and Chromatography
- Adolescent and Pediatric Healthcare
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Diverticular Disease and Complications
- Olfactory and Sensory Function Studies
- Immunodeficiency and Autoimmune Disorders
- Parasitic Infections and Diagnostics
- Iron Metabolism and Disorders
- NF-κB Signaling Pathways
- Digestive system and related health
University of Liverpool
2016-2025
Aintree University Hospitals NHS Foundation Trust
2020-2024
Instituto Superior Politécnico Metropolitano de Angola
2024
Royal Liverpool and Broadgreen University Hospital NHS Trust
2016-2022
National Hospital for Neurology and Neurosurgery
2019-2021
University College London
2019-2021
Cellular Research (United States)
2020
King's College London
2018
Guy's and St Thomas' NHS Foundation Trust
2018
Royal Liverpool University Hospital
2013-2015
Little is known about the volatile organic compounds (VOCs) in feces and their potential health consequences. Patients healthcare professionals have observed that often smell abnormal during gastrointestinal disease. The aim of this work was to define volatiles emitted from healthy donors patients with Our hypotheses were i) VOCs would be shared health; ii) constant individuals; iii) specific changes occur Volatile emissions defined a cohort longitudinal study. Subsequently, pattern found...
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be to protect our patients clinical services they rely on. This a novel coronavirus; much unknown as how it will affect people with IBD. We also lack information about impact different immunosuppressive medications....
BackgroundManagement strategies and clinical outcomes vary substantially in patients newly diagnosed with Crohn's disease. We evaluated the use of a putative prognostic biomarker to guide therapy by assessing randomised either top-down (ie, early combined immunosuppression infliximab immunomodulator) or accelerated step-up (conventional) treatment strategies.MethodsPROFILE (PRedicting Outcomes For disease using moLecular biomarker) was multicentre, open-label, biomarker-stratified,...
The aim of this work was to investigate volatile organic compounds (VOCs) emanating from urine samples determine whether they can be used classify into those prostate cancer and non-cancer groups. Participants were men referred for a trans-rectal ultrasound-guided biopsy because an elevated specific antigen (PSA) level or abnormal findings on digital rectal examination. Urine collected patients with (n = 59) cancer-free controls 43), the day their biopsy, prior procedure. VOCs headspace...
Diagnosing irritable bowel syndrome (IBS) can be a challenge; many clinicians resort to invasive investigations in order rule out other diseases and reassure their patients. Volatile organic metabolites (VOMs) are emitted from feces; understanding changes the patterns of these VOMs could aid our etiology disease development biomarkers, which assist diagnosis IBS. We report first comprehensive study fecal patients with diarrhea-predominant IBS (IBS-D), active Crohn's (CD), ulcerative colitis...
Inflammatory bowel disease (IBD) is associated with anaemia and oral iron replacement to correct this can be problematic, intensifying inflammation tissue damage. The intestinal microbiota also plays a key role in the pathogenesis of IBD, supplementation likely influences gut bacterial diversity patients IBD. Here, we assessed impact dietary iron, using chow diets containing either 100, 200 or 400 ppm, fed ad libitum adult female C57BL/6 mice presence absence colitis induced dextran sulfate...
Colorectal cancer remains a leading cause of mortality and morbidity. The UK Bowel Cancer Screening Programme (BCSP) has demonstrated that detection colorectal at an earlier stage identification advanced pre-malignant adenomas reduces morbidity.To assess the utility volatile organic compounds as biomarker for neoplasia.Faeces were collected from symptomatic patients people participating in BCSP, prior to colonoscopy. Headspace extraction followed by gas chromatography mass spectrometry was...
A growing body of evidence indicates that patients with sessile serrated adenoma/polyp (SSA/P) and traditional adenoma (TSA) are at risk for subsequent malignancy. Despite increasing knowledge on histological categorization polyps (SPs) data lacking the actual prevalence association each SP subtype advanced colorectal neoplasia.We prospectively determined different subtypes evaluate synchronous neoplasia in asymptomatic average-risk subjects undergoing first-time colonoscopy. All retrieved...
Abstract Background The diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy. There is a need for biomarkers to reduce the frequency cystoscopy in surveillance; urinary volatile organic compound (VOC) analysis could fulfil this role. This cross-sectional study compared VOC profiles patients with without UBC, investigate metabolomic signatures as biomarkers. Methods Urine samples were collected from haematuria clinic undergoing diagnostic UBC surveillance. Urinary...
Predicting when a patient with advanced cancer is dying challenge and currently no prognostic test available. We hypothesised that process from associated metabolic changes specifically in volatile organic compounds (VOCs). analysed urine patients lung the last weeks of life by headspace gas chromatography mass spectrometry. Urine was acidified or alkalinised before analysis. VOC were identified using univariate, multivariate linear regression analysis; 12 VOCs increased (11 acid dataset, 2...
ABSTRACT Objective: To determine differences in the profiles of volatile organic compounds (VOCs) faecal samples from preterm infants who develop necrotising enterocolitis (NEC) compared with non‐NEC controls. Materials and Methods: Daily were collected prospectively during an 8‐month period a level 3 regional neonatal intensive care unit. Six subsequently developed NEC matched 7 infants. Solid‐phase microextraction gas chromatography mass spectrometry used to extract identify VOCs headspace...
Real-life data on vedolizumab effectiveness in inflammatory bowel disease (IBD) are still emerging. Data the comparative safety of gut selective profile particular interest.To assess clinical outcome and IBD patients treated with vedolizumab.We retrospectively collected at eight UK hospitals (August 2014-January 2018). Clinical response remission 14 52 weeks evaluated through Physician Global Assessment (PGA) adverse events were recorded. Possible predictors examined.Two hundred three (mean...
Background The Neuberger review made a number of recommendations to improve end life care, including research into the biology dying. An important aspect dying is identification biomarkers as indices disease processes. Biomarkers have potential inform current, limited understanding process and assist clinicians in recognising dying, particular how distinguish from reversible acute deterioration. Objectives To critically appraise literature on biological factors that may be used prognostic...
Summary Background The low FODMAP diet (LFD) leads to clinical response in 50%–80% of patients with irritable bowel syndrome (IBS). It is unclear why only some respond. Aims To determine if differences baseline faecal microbiota or and urine metabolite profiles may separate responders the from non‐responders allowing predictive algorithms be proposed. Methods We recruited adults fulfilling Rome III criteria for IBS a blinded randomised controlled trial. Patients were sham placebo supplement...
There is a need to reduce the number of cystoscopies on patients with haematuria. Presently there are no reliable biomarkers screen for bladder cancer. In this paper, we evaluate new simple in-house fabricated, GC-sensor device in diagnosis cancer based volatiles. Sensor outputs from 98 urine samples were used build and test diagnostic models. Samples taken 24 transitional (urothelial) cell carcinoma (age 27-91 years, median 71 years) 74 controls presenting urological symptoms, but without...