A5090971328- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Gastroesophageal reflux and treatments
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Intestinal and Peritoneal Adhesions
- Microscopic Colitis
- Celiac Disease Research and Management
University of Pisa
2022-2024
The Lyon Consensus designates Los Angeles (LA) grade C/D esophagitis or acid exposure time (AET) >6% on impedance-pH monitoring (MII-pH) as conclusive for gastroesophageal reflux disease (GERD). We aimed to evaluate proportions with objective GERD among symptomatic patients LA A, B, and C endoscopy.Demographics, clinical data, endoscopy findings, proton-pump inhibitor response were collected from prospectively enrolled 2 referral centers. Off-therapy MII-pH parameters included AET, number of...
The role of inhaled and swallowed aeroallergens in treatment outcomes adult patients with eosinophilic esophagitis (EoE) is unclear. We hypothesized that the pollen season contributes to failure 6-food elimination diet (SFED) EoE.We compared EoE who underwent SFED during vs outside season. Consecutive skin prick test (SPT) for birch grass were included. Individual sensitization count data analyzed define whether each patient had been assessed or after SFED. All active (≥15...
Eosinophilic esophagitis (EoE) requires maintenance therapy to avoid recurrence. We investigated the efficacy of a second course proton pump inhibitors (scPPIs) maintain steroid-induced histological remission (HR) in patients with EoE who had previously failed induction PPIs.We retrospectively included 18 achieved HR topical steroids but could not be maintained on long-term steroids. Treatment outcomes were assessed after 12 weeks scPPIs.Most (67%) high-dose PPI monotherapy at week 12.scPPIs...
Chicago classification version 4.0 (CCv4.0) introduced stringent diagnostic criteria for oesophagogastric junction outflow obstruction (EGJOO), in order to increase the clinical relevance of diagnosis, although this has not yet been demonstrated.To determine prevalence EGJOO using CCv4.0 patients with CCv3.0-based EGJOO, and assess if provocative manoeuvres can predict a conclusive diagnosis EGJOO.Clinical presentation, high resolution manometry (HRM) rapid drink challenge (RDC), timed...
Esophageal symptom-specific anxiety, hypervigilance, and adaptive behaviors at mealtime may affect dysphagia reporting in patients with eosinophilic esophagitis (EoE) but this has not been investigated. Moreover, the relationship between such confounding factors histological disease activity (HDA) is unclear. This was a prospective study on adults EoE. Dysphagia, hypervigilance were assessed using specific questionnaires (i.e., mDSQ, DSS, EHAS). Adaptive Pisa EoE Adaptation Questionnaire....
<h3>Background & Aims</h3> The role of inhaled and subsequently swallowed aeroallergens in treatment outcomes adults with eosinophilic esophagitis (EoE) is unclear. We hypothesized that the pollen season contributes to failure dietary therapy EoE. In this international two-centre study, we compared six-food elimination diet (SFED) EoE patients assessed on- versus off- season. <h3>Methods</h3> Consecutive adult (≥18 years) who underwent SFED skin prick test (SPT) for birch grass were...
<h3>Background and Aims</h3> Eosinophilic esophagitis (EoE) gastroesophageal reflux disease (GERD) may coexist. The role of GERD in histologically PPI (proton pump inhibitors)-refractory (PPI-R) EoE has been poorly investigated. We characterized ambulatory monitoring findings heartburn outcomes PPI-R patients undergoing 96-h wireless pH (WPM) or 24-h pH-impedance (MII-pH). <h3>Methods</h3> In this international study conducted two referral centres, we enrolled consecutive with who did not...