A5077474266- Celiac Disease Research and Management
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Gut microbiota and health
- Gastroesophageal reflux and treatments
- Biosimilars and Bioanalytical Methods
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Child Nutrition and Feeding Issues
- Nutrition and Health in Aging
- Congenital gastrointestinal and neural anomalies
- Clinical Laboratory Practices and Quality Control
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and healthcare impacts
- Clinical Nutrition and Gastroenterology
- Calcium signaling and nucleotide metabolism
- Adolescent and Pediatric Healthcare
- Bariatric Surgery and Outcomes
University of Padua
2015-2023
University of California, Davis
2017-2018
Background and Purpose Gut microbiota is essential for the development of gastrointestinal system, including enteric nervous system (ENS). Perturbations gut in early life have potential to alter neurodevelopment leading functional bowel disorders later life. We examined hypothesis that dysbiosis impairs structural integrity ENS, dysmotility juvenile mice. Experimental Approach To induce dysbiosis, broad‐spectrum antibiotics were administered by gavage (3weeks old) male C57Bl/6 mice 14 days....
Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both the enteric nervous system (ENS) and central (CNS) contributing to onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations influence expression molecular factors involved development ENS CNS. In this study, we have evaluated brain-derived neurotrophic factor (BDNF) its high-affinity receptor...
Inflammatory bowel diseases (IBD) are chronic relapsing disorders that have a negative impact on quality of life. They can be highly disabling and been associated with sleep disturbance. The aim our study was to evaluate the large cohort IBD patients identify possible cofactors. We prospectively recruited consecutive attending Unit "Azienda Ospedaliera" Padua from November 2018 May 2019 collected demographics clinical characteristics. completed Pittsburgh Sleep Quality Index (PSQI),...
Edible seaweeds have been consumed by Asian coastal communities since ancient times.
Objective Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on TLR4 tuning structural functional integrity nervous system (ENS) controlling small bowel motility. Methods Male knockout (TLR4-/-, 9±1 weeks old) sex- age-matched wild-type (WT) C57BL/6J mice were used experiments. Alterations ENS morphology neurochemical...
The treatment for coeliac disease (CD) has a considerable psychological impact on patients, which may vary depending subjects and clinical characteristics. aim of this study was to describe the quality life (QoL) in CD patients during follow-up, evaluating factors can influence it. Patients with who consecutively visited outpatient clinic Unit University Hospital Padua from January September 2019 were enrolled. Demographics information collected, all asked answer CD-QoL Biagi’s validated...
Enteric glial cells (EGCs) influence nitric oxide (NO)− and adenosine diphosphate (ADP)− mediated signaling in the enteric nervous system (ENS). Since Toll-like receptor 4 (TLR4) participates to EGC homoeostasis, this study aimed evaluate possible involvement of EGCs alterations inhibitory neurotransmission TLR4−/− mice. Ileal segments from male wild-type (WT) C57BL/6J mice were incubated with gliotoxin fluoroacetate (FA). Alterations ENS morphology neurochemical coding investigated by...
Coeliac disease (CeD) has been associated with psychological disorders and reduced quality of life. Our prospective study evaluated the changes in life, anxiety depression CeD patients up to two years after diagnosis. We recruited adult residing Veneto region a new diagnosis CeD. Several validated questionnaires were administered measure symptoms adherence gluten-free diet (GFD) at time 1 2 years. Ninety-three reached 1-year follow-up (81.7% females median age 35 years), 55 2-year follow-up....
Gastroduodenal endoscopy and biopsy following positive specific serology is considered the gold standard to diagnose celiac disease (CeD) in adults. Whether upper helps detect comorbid conditions unknown.To investigate prevalence of non-celiac endoscopic findings patients whom was performed confirm CeD diagnosis.This an observational, descriptive, multicenter, retrospective study that reports obtained adult enrolled local registries from four tertiary centers. We collected data reported on...
Data on vedolizumab (VDZ) use in inflammatory bowel disease (IBD) patients are still limited. We aimed to assess the effectiveness and tolerability of VDZ a real-life clinical scenario.We retrospectively collected data all consecutive IBD who started from September 2016 December 2018 at our Unit University Hospital Padua strictly followed them for 1 year. Clinical benefit (rate steroid-free remission plus response), endoscopic histological responses were evaluated over year.A total 117...
Introduction MicroRNAs (miRNAs) have been proposed as diagnostic markers, biomarkers of neoplastic progression, and possible therapeutic targets in several immune-mediated diseases. We aimed to analyze the expression profile selected miRNAs (miR21, miR142, miR223, miR155) patients with autoimmune atrophic gastritis (AAG), non-autoimmune multifocal (MAG), healthy control subjects (HC). Materials methods A total 103 AAG were consecutively recruited for this study among those attending our...
Oxidized phospholipid derivatives (OxPAPCs) act as bacterial lipopolysaccharide (LPS)-like damage-associated molecular patterns. OxPAPCs dose-dependently exert pro- or anti-inflammatory effects by interacting with several cellular receptors, mainly Toll-like receptors 2 and 4. It is currently unknown whether may affect enteric nervous system (ENS) functional structural integrity.Juvenile (3 weeks old) male C57Bl/6 mice were treated intraperitoneally OxPAPCs, twice daily for 3 days. Changes...
A multitude of natural and artificial compounds have been recognized to modulate autophagy, providing direct or, through associated pathways, indirect entry points activation inhibition. While these pharmacological tools are extremely useful in the study their abundance also suggests potential presence unidentified autophagic modulators that may interfere with experimental designs if applied unknowingly. Here, we report unanticipated effects on autophagy bioenergetics neuronal progenitor...
Background and Aim: Autoimmune atrophic gastritis (AAG) is characterized by a variable spectrum of gastric extra-gastric symptoms has been associated with other autoimmune diseases. It still unknown whether AAG patients have higher risk coeliac disease (CeD) or any particular duodenal histological damage. Our study aimed at evaluating the findings CeD in AAG, without concurrent Methods: We retrospectively collected all adult undergoing upper gastrointestinal endoscopy biopsies our...
The gluten-free diet [GFD] has been linked to an increased risk of weight gain and the development metabolic disorders. Most studies have focused on effect GFD Body Mass Index [BMI]. We aimed evaluate nutritional status using specific parameters in patients with celiac disease [CeD] at diagnosis a compared healthy controls. recruited subjects our outpatient clinic University Padua. collected demographic clinical data values obtained bioelectrical impedance analysis. A total 24 CeD 28...
Ileal interposition (IT) surgery delays the onset of diabetes in a rat model type-2 (UCD-T2DM). Here, to gain deeper understanding molecular events underlying effects IT surgery, we examined changes proteome four white adipose depots (retroperitoneal, mesenteric, inguinal, and epididymal) plasma-free fatty acid profile pre-diabetic rats 1.5 months following or sham surgery. The IT-mediated were exerted mainly mesenteric fat spanned from delayed adipocyte maturation neuroendocrine remodeling....
Background and aim: Nutritional deficiencies are frequent in coeliac disease (CeD), mostly because of the nutritional deficits gluten-free foods wrong behaviors. We aimed to investigate level knowledge a cohort CeD patients comparison with inflammatory bowel (IBD) healthy subjects. Materials methods: consecutively recruited matched-sex -age IBD between April December 2019 at University Hospital Padua outpatient clinic. Healthy subjects were also from family friends hospital staff. The...