A5049462874- Hepatitis C virus research
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Retinal Imaging and Analysis
- Tryptophan and brain disorders
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
- interferon and immune responses
- T-cell and B-cell Immunology
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Infant Nutrition and Health
- Reproductive Health and Technologies
- Vagus Nerve Stimulation Research
- Hepatocellular Carcinoma Treatment and Prognosis
Humanitas University
2019-2025
IRCCS Humanitas Research Hospital
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021
University of Colorado Denver
2013-2015
Cleveland Clinic
2013
University of Colorado Anschutz Medical Campus
2013
Essen University Hospital
2009-2012
University of Duisburg-Essen
2008-2010
Institute of Virology of the Slovak Academy of Sciences
2009
Memorial University of Newfoundland
2009
Up to 40% of patients with inflammatory bowel disease present psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination bacteria from intestine liver. Here, we describe in brain choroid plexus (PVB) is modulated response intestinal inflammation through bacteria-derived lipopolysaccharide. The induces PVB closure after opening by up-regulation wingless-type, catenin-beta 1 (Wnt/β-catenin) signaling pathway, rendering it inaccessible large...
The prevalence of childhood and adolescent obesity has globally reached alarming dimensions many adolescents affected by already present one or more obesity-related comorbidities. In recent years, emerging evidence supporting the role gut microbiota in pathophysiology metabolic diseases been reported use prebiotics, probiotics, synbiotics postbiotics as a strategy to manipulate become popular. aim this review is explore relationship between syndrome discuss potential for prevention treatment...
Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI characterized immunometabolic changes and histone post-translational modifications, enhance production of pro-inflammatory cytokines. As aberrant activation implicated inflammatory diseases, tight regulation critical; however, the mechanisms responsible for this modulation remain elusive. Interleukin-37...
Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell in the defense against viruses. Through pattern recognition receptors (PRRs), these cells detect viral pathogen associated molecular patterns (PAMPs) and initiate an Interferon (IFN) response. pDCs produce antiviral IFNs including well-studied Type I more recently described III. Recent genome wide association studies (GWAS) have implicated III HCV clearance. We examined IFN response induced pDC line ex vivo human by region of...
Abstract Hepatitis C virus (HCV) is the world’s most common blood-borne viral infection for which there no vaccine. The rates of vertical transmission range between 3 and 6% with odds 90% higher in presence HIV coinfection. Prevention not possible because lack an approved therapy use pregnancy or effective Recently, HCV has been identified as independent risk factor preterm delivery, perinatal mortality, other complications. In this study, we characterized immune responses that contribute to...
The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of health care systems during highest viral diffusion rate. Patients reaching emergency department had to be either hospitalized (inpatients) or discharged (outpatients). Still, decision was taken based on individual assessment actual clinical condition, without specific biomarkers predict future improvement deterioration, and patients often returned hospital for aggravation their condition. Here, we have developed a new combined...
The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism T-cell failure. HLA-B*08 was recently identified as HLA class I allele associated with spontaneous clearance Selection mutations in immunodominant HLA-B*08-restricted epitope HSKKKCDEL(1395-1403) observed infection....
Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% gestations worldwide. Its development influenced by maternal immune abnormalities, metabolic disorders, gut dysbiosis. In this study, we show that dysbiosis C57BL/6J dams leads to increased fetal resorption, impaired placental altered vascularization. These adverse outcomes are associated with key pathological features preeclampsia, including hypoxia, endoplasmic reticulum (ER) stress reduction...
Abstract The inherent sequence diversity of the hepatitis C virus (HCV) with existence multiple genotypes that differ up to 20% at amino acid level represents one major obstacles for immune control. Accordingly, control a heterologous challenge, particularly across genotypes, is difficult achieve; however, overall role genotype-specific differences has not yet been defined epitope level. aim this study was determine CD8+ T cell response against HCV. We analyzed cohort anti-HCV–positive...
Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell in the defense against viruses.Through pattern recognition receptors (PRRs), these cells detect viral pathogen associated molecular patterns (PAMPs) and initiate an Interferon (IFN) response.pDCs produce antiviral IFNs including well-studied Type I more recently described III.Recent genome wide association studies (GWAS) have implicated III HCV clearance.We examined IFN response induced pDC line ex vivo human pDCs by region of...
Aims: Distinct HLA-class I alleles have a differential impact on the outcome of HCV infection. In Irish Anti-D cohort HLA-B27 was associated with spontaneous control and HLA-B8 viral persistence. Although protective effect confirmed in other cohorts, discrepant results been obtained for HLA-B8. The aim this study is to determine role sequence differences source virus these alleles.
Background: NAFLD is a prevalent problem throughout the Western world.LSECs have been shown to play important roles in liver injury and repair but their role underlying pathogenetic mechanisms of remains undefined.Here we evaluated effects steatosis on LSEC expression genes involved inflammation, apoptosis, angiogenesis cell adhesion murine model an immortalized human line.Methods: To evaluate gene changes during C56BL/6 mice were fed western diet (21% anhydrous milkfat (butterfat), 34%...