A5082301646- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Growth Hormone and Insulin-like Growth Factors
- COVID-19 Impact on Reproduction
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Animal Genetics and Reproduction
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Neuroendocrine regulation and behavior
- Sperm and Testicular Function
- Adolescent Sexual and Reproductive Health
Research Institute for Farm Animal Biology (FBN)
2022-2025
Humanitas University
2025
IRCCS Humanitas Research Hospital
2025
To date, animal models with reproductive phenotypes are knockout or transgenic and typically exhibit reduced fertility infertility. This limits research to studying single-gene effects loss of fertility. By contrast, Dummerstorf high-fertility mouse lines 1 2 (FL1 FL2) two unique outbred selection that demonstrate exceptional performance. After approximately 50 years selection, both have doubled the number ovulated oocytes per cycle consequently their litter size (>20 vs ∼11) compared...
Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% gestations worldwide. Its development influenced by maternal immune abnormalities, metabolic disorders, gut dysbiosis. In this study, we show that dysbiosis C57BL/6J dams leads to increased fetal resorption, impaired placental altered vascularization. These adverse outcomes are associated with key pathological features preeclampsia, including hypoxia, endoplasmic reticulum (ER) stress reduction...
Mouse models of decreased fertility mainly support scientific knowledge in the field reproductive biology. In this study, we changed perspective, using Dummerstorf high-fertility mouse lines FL1 and FL2 selected for increased performances that doubled amount ovulated oocytes per cycle number offspring litter compared to an unselected control line (founder population, FZTDU, ctrl). After recent observations, both seem show a lower pregnancy rate ctrl together with atypical cycle. We analysed...
In recent decades, fertility traits in humans as well farm animals have decreased worldwide. As such, it is imperative to know more about the genetics and physiology of increased or high fertility. However, most current animal models with reproductive phenotypes describe lower even infertility (around 99%). The “Dummerstorf high-fertility lines” (FL1 FL2) are two unique mouse lines selected for higher performances, specifically number pups per litter. We recently described how those...
Dummerstorf fertility lines FL1 and FL2 represent two models of enhanced characterized by the doubling litter size compared with an unselected control population (ctrl line, FztDU). Both biodiverse FLs managed to reach this goal increasing ovulation rate per cycle, even showing decreased pregnancy irregular oestrous cycle metabolic hormone levels, ctrl. The aim present study was analyse oocytes in terms quality quantity comparing entire pool ovary, those from antral follicles within same...
Declining human fertility worldwide is an attractive research target for the search "high fertility" genes and pathways to counteract this problem. To study these high fertility, superfertile Dummerstorf mouse lines FL1 FL2 are two unique model organisms representing improved phenotype. A direct reason remarkable characteristic of increased litter size, which reaches >20 pups/litter in both FLs, raised ovulation rate by approximately 100%, impressive record field. high-fertility incarnate...