A5025576874- Leech Biology and Applications
- Wound Healing and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Photoacoustic and Ultrasonic Imaging
- Cardiac Fibrosis and Remodeling
- Reproductive System and Pregnancy
- Immune cells in cancer
- Venomous Animal Envenomation and Studies
- Immune Response and Inflammation
- Healthcare and Venom Research
- Pregnancy and preeclampsia studies
- Optical Imaging and Spectroscopy Techniques
- Adolescent Sexual and Reproductive Health
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Gestational Diabetes Research and Management
- Cardiovascular Effects of Exercise
- Glycosylation and Glycoproteins Research
- Orthopedic Infections and Treatments
- Birth, Development, and Health
- Biomarkers in Disease Mechanisms
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Cardiac electrophysiology and arrhythmias
IRCCS Humanitas Research Hospital
2019-2025
Humanitas University
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
IRCCS Ospedale San Raffaele
2022
University of Insubria
2012-2015
Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little insight exists on other immune subsets involved cardiotoxic response.Here, we used single-cell RNA sequencing map composition standard murine nonischemic, pressure-overload failure model. By focusing our analysis CD45+ cells, obtained higher resolution identification cell heart, at early late stages disease controls. We then...
microRNAs (miRNAs) modulate gene expression by repressing translation of targeted genes. Previous work has established a role for miRNAs in regulating vascular smooth muscle cell (VSMC) activity. Whether circular RNAs are involved the modulation miRNA activity VSMCs is unknown.We aimed to identify interacting with enriched and modulating cells' activity.RNA sequencing bioinformatics identified several VSMCs; however, only one, possessing multiple putative binding sites miR-145, was highly...
Abstract Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a of the humoral arm innate immunity involved in resistance to bacterial infection and regulation tissue remodeling. Here we investigate role SAP antifungal resistance. Apcs −/− mice show enhanced susceptibility A. fumigatus infection. Murine human bound conidia, activate complement cascade enhance phagocytosis by neutrophils. are defective vivo terms recruitment neutrophils lungs. Opsonic activity dependent on...
Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% gestations worldwide. Its development influenced by maternal immune abnormalities, metabolic disorders, gut dysbiosis. In this study, we show that dysbiosis C57BL/6J dams leads to increased fetal resorption, impaired placental altered vascularization. These adverse outcomes are associated with key pathological features preeclampsia, including hypoxia, endoplasmic reticulum (ER) stress reduction...
The difficulty to unambiguously identify the various subsets of mononuclear phagocytes (MNPs) intestinal lamina propria has hindered our understanding initial events occurring after mucosal exposure HIV-1. Here, we compared composition and function MNP at steady-state following ex vivo in viral human macaque colorectal tissues. Combined evaluation CD11c, CD64, CD103, CX3CR1 expression allowed differentiate MNPs common both species. Among them, CD11c+ CX3CR1+ cells expressing CCR5 migrated...
Pulmonary hypertension is a complex disorder characterized by pulmonary vascular remodeling and right ventricular hypertrophy, leading to heart failure. The mechanisms underlying this process are not well understood. We hypothesize that the structural occurring in cardiomyocytes of ventricle affects cytosolic Ca2+ handling arrhythmias. After 12 days monocrotaline-induced rats, epicardial mapping showed electrical both ventricles. In myocytes isolated from hypertensive combination high-speed...
Abstract Acidic pH occurs in acute wounds progressing to healing as consequence of a cell metabolic adaptation response injury-induced tissue hypoperfusion. In tumours, high rate leads acidosis affecting cancer progression. affects activities remodelling cells vitro . The measurement predicts pathological and success surgical treatment burns chronic ulcers. However, current methods are limited skin surface or based on detection fluorescence intensity specific sensitive probes that suffer...
Abstract Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% gestations worldwide. Several factors such as abnormalities maternal immunity, metabolic disorders gut dysbiosis are known to contribute disease development. Here, we show that C57BL/6J dams increased fetal resorption, impaired placental development altered vascularization. These changes positively correlated with hypoxia reduced uterine NK cell number. Moreover, intestinal significantly...