A5042742414- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Reproductive Physiology in Livestock
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Digestive system and related health
- Genetics and Physical Performance
- Reproductive Biology and Fertility
- Pancreatic function and diabetes
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Infant Nutrition and Health
- Fibroblast Growth Factor Research
- Congenital heart defects research
- Birth, Development, and Health
- Animal Genetics and Reproduction
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Exercise and Physiological Responses
- Genetics, Aging, and Longevity in Model Organisms
Research Institute for Farm Animal Biology (FBN)
2015-2025
Heidelberg University
2017-2018
University Hospital Heidelberg
2017-2018
Institute of Animal Science
2016
Ludwig-Maximilians-Universität München
2001-2015
Leibniz Association
2014-2015
Zimmer Biomet (Germany)
2006-2013
Klinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation
2009
Institut Pasteur
2004
Research Institute of Molecular Pathology
2004
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) has been shown to inhibit IGF-dependent cell proliferation in a number of vitro studies. However, no vivo model IGFBP-2 overexpression established so far. Therefore, we have generated transgenic mice, which expression mouse complementary DNA is controlled by the cytomegalovirus (CMV) promoter. In two independent strains, transgene was highest pancreas and stomach, followed skeletal muscle, heart, colon, spleen, adipose tissue,...
Recent findings regarding the response of fibronectin type III domain-containing protein 5 (Fndc5) and irisin to exercise are partly controversial.While 25 kDa form Fndc5 can be observed in muscle serum different species, ~12 band was not detectable up now.The present study aimed clarify whether exists its theoretical size mice if it is affected by exercise.Male were randomly assigned a sedentary control group (CO), with free access running wheels (RW), treadmill (TM).Blood leg muscles...
Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish large animal model for LS, pigs with GHR knockout (KO) were generated and characterized.
ABSTRACT: This study was conducted to investigate the relationships between results of computer‐assisted semen analysis (spermatozoal motility and sperm head morphometry) fertility boars. In addition, concentrations insulin‐like growth factor (IGF)‐I IGF‐II in seminal plasma were determined. The nonreturn rate (NRR) number live‐born piglets compatible with requirements artificial insemination for all boars included this study. Semen samples 12 (Pietrain; 3 ejaculates each) evaluated...
Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show dramatic reduction in body size. Growth hormone signaling mediated by Stat5 transcription factors is impaired. We that proteins physically interact with GR and present vivo on Stat5-dependent IGF-I ALS regulatory regions. Interestingly, mice DNA-binding-deficient but an unaltered ability to STAT5 (GR dim/dim ) have normal size levels mRNAs. These findings strongly support model which acts as...
IGF binding proteins (IGFBPs) modulate cellular bioavailability and may directly regulate tumor growth invasion. We have previously shown that IGFBP-2 binds localizes IGF-I to the pericellular matrix provided some evidence suggesting heparin domain (HBD) or arginine-glycine-aspartic acid (RGD) integrin motif be involved in these interactions. However, precise mechanisms remain elucidated. therefore mutated HBD RGD sequence of investigated consequent effects on extracellular (ECM) binding,...
The adrenal gland is of critical importance for a plethora biological processes. We performed the first systematic analysis growth using unbiased stereological methods in male and female mice from weaning to adulthood ( weeks 3, 5, 7, 9, 11) at organ, compartment, cellular levels. Adrenal weights increased week 3 7 mice, remained this level females, but decreased by 25% between 9 males. Female glands displayed higher weight any stage investigated. volume zona fasciculata was consistently vs....
Myotonic dystrophy type 1 (DM1) is caused by an unstable CTG repeat expansion in the 3′UTR of DM protein kinase (DMPK) gene. DMPK transcripts carrying CUG expansions form nuclear foci and affect splicing regulation various RNA transcripts. Furthermore, bidirectional transcription over gene non-conventional translation repeated have been described DM1. It clear now that this disease may involve multiple pathogenic pathways including changes expression, stability regulation, translation,...
The pre-weaning period is critical for calf health and growth, intensive milk feeding programs may assist postnatal development by improving body growth organ maturation. aim of the present work was to study effects ad libitum replacer (MR) on metabolic adaptation, health, immune status newborn calves. Twenty-eight Holstein x Charolais crossbred calves were fed (ADLIB) or in restricted amounts (6 liters per day; RES) during first five weeks life. MR intake ADLIB treatment gradually reduced...
To clarify the role of insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) in postnatal regulation, we crossed hemizygous CMV-IGFBP-2 transgenic mice with PEPCK-bGH mice, which are characterized by serum GH levels range 2 microgram/ml. Four genetic groups were obtained: animals carrying both transgenes (GB), (G) or IGFBP-2 transgene (B), and nontransgenic controls (C). Male offspring analyzed for IGF-I, tissue IGFBP-2, body organ growth. Serum IGF-I 2- to 3-fold increased (P <...
Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in adults and also used as part of a treatment children with epilepsy. However, potential risks side effects remain controversial. We investigated LC-HF on growth, bone mineral density (BMD), turnover growing rats fed 4 weeks either normal chow (CH, 9% fat, 33% protein, 58% carbohydrates), LC-HF-1 (66% 1% or LC-HF-2 (94.5% 4.2% 1.3% carbohydrates). Rats accumulated significantly more visceral marrow fat showed...