A5012305407- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- IL-33, ST2, and ILC Pathways
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Celiac Disease Research and Management
- Cancer Cells and Metastasis
- Stoma care and complications
- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diagnosis and treatment of tuberculosis
- Gastrointestinal motility and disorders
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
Cleveland Clinic Lerner College of Medicine
2016-2025
Cleveland Clinic
2016-2025
Cerner (United States)
2017-2024
University College London
2024
Mayo Clinic in Arizona
2024
University of Calgary
2024
University of Ljubljana
2024
Ljubljana University Medical Centre
2024
Charité - Universitätsmedizin Berlin
2009-2024
Western University
2024
This paper is the first in a series of two publications relating to European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on diagnosis management disease concerns methodology process, classification, medical active quiescent disease. Surgical as well special situations including perianal this ECCO Consensus are covered subsequent second [Gionchetti et al JCC 2016].
Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation during liver fibrosis. The origin of such is still debated, although several studies point stellate cells as principal source. role adult hepatocytes in yet undetermined. Here, we provide evidence that pro-fibrotic growth factor, TGF-beta1, induces mouse undergo phenotypic and functional changes typical epithelial mesenchymal transition (EMT). We perform lineage-tracing experiments using AlbCre....
Chapter 4: Scores for Inflammatory Bowel Disease 4.1 Clinical and endoscopic scoring systems in IBD Statement 4.1.ECCO-ESGAR Diagnostics GL (2018) indices are useful standardizing disease activity.However, despite widespread use, no score has been validated clinical practice [EL5] ulcerative colitisThere several presently available to classify severity colitis (UC) within the multiple domains of activity, which aid objective assessment guide therapeutic monitoring strategies [1,2].Although...
This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focused on prediction, diagnosis, management fibrostenosing disease [CD]. The objective was to achieve evidence-supported, expert consensus that provides guidance for clinical practice.
This article reports on the sixth scientific workshop of European Crohn's and Colitis Organisation [ECCO] pathogenesis extraintestinal manifestations [EIMs] in inflammatory bowel disease [IBD]. paper has been drafted by 15 ECCO members 6 external experts [in rheumatology, dermatology, ophthalmology, immunology] from 10 countries USA. Within workshop, contributors formed subgroups to address specific areas. Following a comprehensive literature search, supporting text was finalized under...
Interleukin (IL)-18, initially described as interferon (IFN)-γ-inducing factor, is expressed in the inflamed mucosa of patients with Crohn's disease. To investigate role IL-18 intestinal inflammation, effect neutralizing antimurine antiserum dextran sulfate sodium (DSS)-induced colitis BALB/c and C57BL/6 mice was examined. During a dose response DSS, levels colonic increased parallel clinical worsening. With use confocal laser microscopy, localized to epithelial layer. Anti-IL-18 treatment...
Summary Background Fibrosis in ulcerative colitis has remained largely unexplored despite its clinical implications. Aims This cross‐sectional study was aimed at characterising the presence, anatomical location and degree of colitis‐associated fibrosis possible link to parameters. Methods Seven hundred six individual tissue cross‐sections derived every 10 cm along length 89 consecutive Ulcerative colectomy specimens were examined compared Crohn's disease colitis, diverticular uninvolved...