A5067050108- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- IgG4-Related and Inflammatory Diseases
- Gut microbiota and health
- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Caveolin-1 and cellular processes
- Pediatric Hepatobiliary Diseases and Treatments
- Mesenchymal stem cell research
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
Nagoya University
2015-2025
Liechtenstein Institute
2023
Nagoya University Hospital
2022
Nagoya City University
2021
Waseda University
2017-2018
Tokai Central Hospital
2013
Respiratory Clinical Trials
2003
Shibaura Institute of Technology
2001-2002
Teine Keijinkai Hospital
2000
Hakodate National Hospital
1992
Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. Recent observations in genetically engineered mouse models and clinical studies have suggested that there may exist at least two functionally different populations CAFs, is, cancer-promoting CAFs (pCAF) cancer-restraining (rCAF). Although various pCAF markers been identified, identity rCAFs remains unknown because lack rCAF-specific marker(s). In this study, we found Meflin,...
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM or skeletal stem cells. Whereas MSCs have been exploited clinical medicine, the identification of MSC-specific markers has limited. Here, we report that a cell surface and secreted protein, Meflin, is expressed cultured MSCs, fibroblasts pericytes, but not other types including epithelial, endothelial smooth muscle In vivo, Meflin by immature osteoblasts chondroblasts. addition, found on distributed...
Eighty-nine primary lung carcinomas and 23 metastatic tumors were immunohistochemically studied for the expression of pulmonary surfactant apoproteins, by using monoclonal (PE-10) polyclonal antibodies. Surfactant apoprotein was demonstrated in cytoplasm and/or nuclear inclusion bodies only adenocarcinomas (36 75 cases), not any other histologic type carcinoma or tumors. In adenocarcinoma, although typical II pneumocyte adenocarcinoma included current series, majority apoprotein-positive...
Myofibroblasts have roles in tissue repair following damage associated with ischemia, aging, and inflammation also promote fibrosis stiffening, causing organ dysfunction. One source of myofibroblasts is mesenchymal stromal/stem cells that exist as resident fibroblasts multiple tissues. We previously identified meflin (mesenchymal stromal cell- fibroblast-expressing Linx paralogue), a glycosylphosphatidylinositol-anchored membrane protein, specific marker regulator their undifferentiated...
Mucosal healing, confirmed by endoscopic evaluation, is the long-term goal of treatment for Crohn's disease (CD). Leucine-rich alpha-2 glycoprotein (LRG) a new serum biomarker correlated with activity in inflammatory bowel disease. However, studies evaluating its relationship CD, particularly context small intestinal lesions, are scarce. The aim this study was to investigate accuracy LRG assessing activity, especially remission, patients CD.Between July 2020 and March 2021, 72 CD who...
We aimed to develop a new artificial intelligence (AI)-based method for evaluating endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) specimens in pancreatic diseases using deep learning and contrastive learning. analysed total of 173 from 96 patients who underwent EUS-FNB with 22 G Franseen needle diseases. In the initial study, based on stereomicroscopic images 98 63 showed an accuracy 71.8% predicting histological diagnosis, which was lower than that macroscopic on-site evaluation...
Abstract Background The proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to immune checkpoint blockade (ICB) therapy. However, it has remained a challenge develop therapeutics that specifically target or modulate CAFs. Methods We investigated the involvement Meflin + cancer-restraining CAFs (rCAFs) in ICB efficacy patients with clear cell renal carcinoma (ccRCC) urothelial (UC). examined effects Am80 (a synthetic...
Pathological observations show that cancer cells frequently invade the surrounding stroma in collective groups rather than through single cell migration. Here, we studied role of actin-binding protein Girdin, a specific regulator migration neuroblasts brain, We found Girdin was essential for skin line A431 on collagen gels as well their fibroblast-led invasion an organotypic culture model. provide evidence binds to β-catenin plays important roles Wnt signaling pathway and E-cadherin-mediated...
Abstract Background Cancer-associated fibroblasts (CAFs) are an important component of the tumour microenvironment. Recent studies revealed CAFs heterogeneous and CAF subset(s) that suppress cancer progression (cancer-restraining [rCAFs]) must exist in addition to well-characterised cancer-promoting (pCAFs). However, identity specific markers rCAFs not yet reported. We recently identified Meflin as a marker pancreatic colon cancers. Our may represent proliferating resident fibroblasts....
Abstract Background Fecal microbiota transplantation (FMT) is a potential treatment for irritable bowel syndrome (IBS), but its efficacy in Japanese IBS patients unknown. This study aimed to evaluate the efficacy, side effects, and microbiome changes following FMT patients. Methods Seventeen with refractory received (4 donors) under colonoscopy. Responders were defined by an improvement severity index (IBS-SI) of 50 points or more after 12 weeks. We evaluated IBS-SI Bristol Stool Form Scale...
The prognosis of elderly individuals with idiopathic pulmonary fibrosis (IPF) remains poor. Fibroblastic foci, in which aggregates proliferating fibroblasts and myofibroblasts are involved, the pathological hallmark lesions IPF to represent focal areas active fibrogenesis. Fibroblast heterogeneity fibrotic hampers discovery pathogenesis fibrosis. Therefore, determine IPF, identification functional is warranted. aim this study was role positive for meflin, identified as a potential marker...
Abstract Background Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of whole GI tract, but its diagnostic yield for CD lesions in remains unknown. Aim To elucidate PCCE-2 patients with CD. Methods Patients who underwent double-balloon (DBE) using oral anal approaches were evaluated tract. We divided bowel into three segments (jejunum, ileum, terminal ileum), four (right colon,...
In pancreatic hypervascular masses, it is often difficult to differentiate neuroendocrine neoplasm (PanNEN) and intrapancreatic accessory spleen (IPAS) before surgery because of their similar features, such as a round shape early enhancement. This study aimed examine the efficacy endoscopic ultrasonography (EUS) for differentiating between them. retrospective pilot enrolled 136 patients with pathologically confirmed non-functional PanNEN or IPAS who underwent EUS at our institution. The...
Malignant mesothelioma is an aggressive neoplasm for which effective treatments are lacking. We often encounter cases with a profound desmoplastic reaction, suggesting the involvement of cancer‑associated fibroblasts (CAFs) in progression. While roles CAFs have been extensively studied other tumors and led to view that cancer stroma contains heterogeneous populations CAFs, their remain unknown. previously showed connective tissue growth factor (CTGF), secreted protein, produced by both cells...