A5087833156- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Meningioma and schwannoma management
- Liver physiology and pathology
- Cephalopods and Marine Biology
- Renal cell carcinoma treatment
- Veterinary Pharmacology and Anesthesia
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Renal and related cancers
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Anodic Oxide Films and Nanostructures
Nagoya University
2016-2025
Nagoya University Hospital
2022-2023
Ogaki Municipal Hospital
2023
XinHua Hospital
2016
Tosei General Hospital
2012
Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. Recent observations in genetically engineered mouse models and clinical studies have suggested that there may exist at least two functionally different populations CAFs, is, cancer-promoting CAFs (pCAF) cancer-restraining (rCAF). Although various pCAF markers been identified, identity rCAFs remains unknown because lack rCAF-specific marker(s). In this study, we found Meflin,...
There are no accurate mass screening methods for early detection of central nervous system (CNS) tumors. Recently, liquid biopsy has received a lot attention less-invasive cancer screening. Unlike other cancers, CNS tumors require efforts to find biomarkers due the blood–brain barrier, which restricts molecular exchange between parenchyma and blood. Additionally, because satisfactory way collect urinary is lacking, urine-based not been fully investigated despite fact that it some advantages...
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape TME toward immunosuppressive milieu and attenuate efficacy immune checkpoint blockade (ICB) therapy. However, detailed mechanism how heterogeneous regulate response to ICB therapy has not been defined. Here, we show that a recently defined CAF subset characterized by expression Meflin, glycosylphosphatidylinositol-anchored protein marker mesenchymal stromal/stem cells, is...
Abstract Background Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific not yet been identified because of the limited number representative research models Methods We performed organoid cultures using meningioma cells and tumor tissues. Using immunohistochemistry analyses consisting whole-exome sequencing, RNA-seq, DNA methylation analyses, we compared histological...
The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) includes a complex interaction metabolic stress and inflammatory stimuli. Considering the therapeutic goals NASH, it is important to determine whether treatment can prevent progression from NASH hepatocellular carcinoma. Taxifolin, also known as dihydroquercetin, natural bioactive flavonoid with antioxidant anti-inflammatory properties commonly found in various foods health supplement products. In this study, we demonstrated...
Abstract Background The proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to immune checkpoint blockade (ICB) therapy. However, it has remained a challenge develop therapeutics that specifically target or modulate CAFs. Methods We investigated the involvement Meflin + cancer-restraining CAFs (rCAFs) in ICB efficacy patients with clear cell renal carcinoma (ccRCC) urothelial (UC). examined effects Am80 (a synthetic...
In the progression of glioma, tumour cells often exploit perivascular microenvironment to promote their survival and resistance conventional therapies. Some these are considered be brain stem (BTSCs); however, molecular nature has not been specifically clarified because complexity glioma. Here, we identified CD109, a glycosylphosphatidylinositol-anchored protein regulator multiple signalling pathways, as critical lower-grade glioma (World Health Organization grade II/III) by...
Germline-mutation in BRCA1 tumor suppressor gene is an established risk for carcinogenesis not only females but also males. Deficiency the repair of DNA double-strand breaks hypothesized as a responsible mechanism carcinogenesis. However, supporting data insufficient both mutation spectra cancers patients with germline-mutation and murine knockout/knock-in models Brca1 haploinsufficiency. Furthermore, information on driving force toward carriers lacking. Here we applied Fenton reaction-based...
The roles of circulating complement C3, produced in hepatocytes, immune defense are well defined the literature. Interestingly, C3 gene evolved before circulatory system, suggesting an essential but yet unknown role locally C3. Here, we investigated effect on cancer immunotherapy and found that cancer-associated fibroblast (CAF)-derived not hepatocyte-derived determines efficacy checkpoint blockade (ICB). Tumors developed CAF-specific knockout mice exhibited resistance to anti-PD-1 therapy,...
Abstract Brown adipose tissue (BAT) is an energy‐consuming organ, and its functional dysregulation contributes to the development of metabolic diseases obesity. BAT function regulated by sympathetic nervous system but declines with age, which partly caused reduced nerve fibers innervating BAT. Thus far, role mesenchymal stromal/stem cells in age‐related dysfunction remains unknown. Here, we show that may be induced a defect antioxidant capacity stromal localize around (perineurial cells)...
Systemic therapeutic regimens for malignant tumors are usually determined on the basis of pathologic diagnosis. Patients undergo later-line same tumor pathology without re-biopsy when they experience progressive disease (PD). In this report, we describe a patient with liver in which transformed from intrahepatic cholangiocarcinoma (ICC) to hepatocellular carcinoma (HCC) after partial response and PD following systemic therapies ICC. The maintained stable regimen HCC ICC regimen. This case...
<title>Abstract</title> The impact on prognosis of neutrophil infiltration in the microenvironment ovarian cancer remains to be elucidated. In this study, we analyzed association between peritoneal metastasis and prognosis. Furthermore, correlation number peripheral blood neutrophils, degree neutropenia, vascular endothelial area, stromal cells. Thirty-four specimens each primary metastatic advanced with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, αSMA was...
Stromal invasion is considered an important prognostic factor in patients with lung adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal have been studied lung; however, they are still unclear. CD109 a glycosylphosphatidylinositol-anchored glycoprotein highly expressed several types human malignant tumors including cancers. In this study, we investigated vivo functions protein tumors. Initially, identified association between higher expression adenocarcinoma...
Diabetes and obesity contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH) hepatocellular carcinoma (HCC). However, how diabetes accelerate liver tumorigenesis remains be fully understood. Moreover, verify therapeutic potential anti-diabetic drugs, there exists a strong need for appropriate animal models that recapitulate human pathophysiology NASH HCC. We established novel murine model NASH-associated tumors using genetically obese melanocortin 4 receptor-deficient mice fed...
Cancer-associated fibroblasts (CAFs), a compartment of the tumor microenvironment, were previously thought to be uniform cell population that promotes cancer progression. However, recent studies have shown CAFs are heterogeneous and there at least two types CAFs, is, cancer-promoting -restraining CAFs. We identified Meflin as candidate marker cancer-restraining (rCAFs) in pancreatic ductal adenocarcinoma (PDAC). The precise nature rCAFs, however, has remained elusive owing lack understanding...
Abstract Mesenchymal stem cells (MSCs) are the likely precursors of multiple lines mesenchymal cells. The existence bona fide MSCs with self‐renewal capacity and differentiation potential into all lineages, however, has been unclear because lack MSC‐specific marker(s) that not expressed by terminally differentiated progeny. Meflin, a glycosylphosphatidylinositol‐anchored protein, is an MSC marker candidate specifically in rare stromal tissues. Our previous report showed Meflin expression...
Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute chronic kidney disease progression. Several PMC markers have been identified; however, heterogeneity and functions are not fully understood. Here, we describe a novel subset of renal PMCs express Meflin, glycosylphosphatidylinositol-anchored protein was recently identified as marker fibroblasts essential for cardiac tissue repair. Tracing the lineage Meflin+ PMCs, found in perivascular...
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that highly expressed in several types of human cancers, particularly squamous cell carcinomas. We previously reported CD109-deficient mice exhibit epidermal hyperplasia and chronic skin inflammation. Although we found regulates differentiation keratinocytes vivo, the function tumorigenesis remains unknown. In this study, investigated role using two-stage carcinogenesis model with Immunohistochemical analysis revealed higher level...
Abstract Identifying specific markers of adipose stem and progenitor cells (ASPCs) in vivo is crucial for understanding the biology white tissues (WAT). PDGFRα‐positive perivascular stromal represent best candidates ASPCs. This cell lineage differentiates into myofibroblasts that contribute to impairment WAT function. However, ASPC marker protein(s) are functionally maintaining homeostasis unknown. We previously identified Meflin as a mesenchymal (MSCs) bone marrow tissue‐resident...
Abstract Normal epithelial cells exert their competitive advantage over RasV12-transformed and eliminate them into the apical lumen via cell competition. However, internal or external factors that compromise competition provoke carcinogenesis remain elusive. In this study, we examine effect of sequential accumulation gene mutations, mimicking multi-sequential on RasV12-induced in intestinal tissues. Consequently, find directionality RasV12-cell extrusion Wnt-activated epithelia is reversed,...
Fibroblasts play a central role in the lung fibrotic process. Our recent study identified novel subpopulation of fibroblasts expressing meflin (mesenchymal stromal cell- and fibroblast-expressing Linx paralogue), antifibrotic properties which were confirmed by murine fibrosis model. Meflin-expressing resistant to fibrogenesis induced TGF-β (transforming growth factor-β), but its underlying mechanisms remain unknown. In this study, evaluation silica-nanoparticle–induced model effect via...
The significance of mammalian target rapamycin complex 1 (mTORC1) activity in the maintenance cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted population leukemia leukemia, while maintaining stemness pancreatic CSCs. purpose this study was to examine currently unknown role and brain tumor (BTSCs). Basal its kinetics were investigated BTSC clones isolated from patients with glioblastoma their differentiated progenies (DIFFs). effects...