A5090393548- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Chromatin Remodeling and Cancer
Nagoya University
2019-2021
Abstract Background Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific not yet been identified because of the limited number representative research models Methods We performed organoid cultures using meningioma cells and tumor tissues. Using immunohistochemistry analyses consisting whole-exome sequencing, RNA-seq, DNA methylation analyses, we compared histological...
The transcriptome analysis of injured Xenopus laevis tadpole and mice suggested that Neurod4L.S., a basic-helix-loop-helix transcription factor, was the most promising factor to exert neuroregeneration after spinal cord injury (SCI) in mammals. We generated pseudotyped retroviral vector with neurotropic lymphocytic choriomeningitis virus (LCMV) envelope deliver murine Neurod4 undergoing SCI. SCI induced ependymal cells neural stem (NSCs) central canal. LCMV envelope-based pseudotypedvector...
Glioblastoma (GBM), the most common and malignant brain tumor, is classified according to its isocitrate dehydrogenase (IDH) mutation status in 2016 World Health Organization (WHO) tumor classification scheme. The standard treatment for GBM maximal resection, radiotherapy, Temozolomide (TMZ). Recently, Bevacizumab (Bev) has been added basic therapy newly diagnosed GBM, monotherapy recurrent GBM. However, effect of IDH1 on combination Bev TMZ unknown. In this study, we performed...
Abstract Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific not yet been identified because of the limited number representative research models We established 18 organoid comprising two malignant meningioma cells (HKBMM and IOMM-Lee), 10 benign meningiomas, four solitary fibrous tumors (SFTs). Using immunohistochemistry analyses consisting whole exome sequencing, RNA-seq,...