A5018469475- Renal and related cancers
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Tissue Engineering and Regenerative Medicine
- Advancements in PLL and VCO Technologies
- Complement system in diseases
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Renal cell carcinoma treatment
- CRISPR and Genetic Engineering
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Ultra-Wideband Communications Technology
- Animal Virus Infections Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Radio Frequency Integrated Circuit Design
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Lymphoblastic Leukemia research
- Animal Genetics and Reproduction
- Signaling Pathways in Disease
- Anesthesia and Neurotoxicity Research
- Microwave Imaging and Scattering Analysis
Nagoya University
2012-2025
Nagoya University Hospital
2022-2024
Shinshu University
2018-2024
Niigata University
2023-2024
Keio University
2024
University of Göttingen
2015-2018
Universitätsmedizin Göttingen
2018
Shinshu University Hospital
2018
Pediatrics and Genetics
2017
Showa University Northern Yokohama Hospital
2015
While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation methylated DNA, reactivating gene expression. We here report generation a high-fidelity CRISPR/Cas9-based dioxygenase by fusing an endonuclease deactivated Cas9 (dHFCas9) TET3 catalytic domain (TET3CD), targeted guiding RNAs (sgRNA). demonstrate use...
Myofibroblasts have roles in tissue repair following damage associated with ischemia, aging, and inflammation also promote fibrosis stiffening, causing organ dysfunction. One source of myofibroblasts is mesenchymal stromal/stem cells that exist as resident fibroblasts multiple tissues. We previously identified meflin (mesenchymal stromal cell- fibroblast-expressing Linx paralogue), a glycosylphosphatidylinositol-anchored membrane protein, specific marker regulator their undifferentiated...
CD109 is a glycosylphosphatidylinositol-anchored cell surface protein that frequently detected in squamous carcinomas. negative regulator of TGF-β1 signaling human keratinocytes, and the N-terminal fragment secreted from cells after cleavage by furin protease important for modulating signaling. Previously, we found expressed glioblastoma cells; however, role not established. Here, describe effects lines. Three lines, SK-MG-1, U251MG MG178, were tested overexpression attenuated enhanced EGF...
Novel coronavirus disease 2019 (COVID-19) refers to infection with the severe acute respiratory syndrome 2 (SARS-CoV-2) pathogen, and has spread pandemic levels since its inception in December 2019. While several risk factors for presentation have been identified, clinical course end-stage renal (ESRD) patients on maintenance hemodialysis COVID-19 unclear. Previous studies revealed that some antiviral agents may be effective against general population, but pharmacokinetics pharmacodynamics...
Fabry disease (FD) is a rare X-linked lysosomal storage disorder. Enzyme replacement therapies (ERT), such as agalsidase α and β, are available treatment options. While infusion-related reactions (IRRs) known to occur at the initiation of ERT owing immune responses, there limited information on IRRs during long-term ERT. We report case female patient with who developed unexpected hypotension after six years stable α, leading switch β. Continuous monitoring may be essential identify potential...
While kidney injury is associated with re-expression of numerous Wnt ligands and receptors, molecular mechanisms which underlie regulation distinct signaling pathways ensuing biological consequences remain incompletely understood. Primary cilia are increasingly being recognized as cellular 'antennae' sense transduce signals from the microenvironment, particularly through signaling. Here, we explored role modulators canonical non-canonical activities involving tubular epithelial cells in...
The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP expressed in variety human and rodent tumor cell lines several kinds cancer. Expression associated with prognosis colon endometrial cancers. In present study, we evaluated expression lung cancer assessed its clinical significance. Tissue microarrays were constructed from 108 cases cancer, sections analyzed for by immunohistochemistry. was detected nucleus 66.7% tissues...
Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute chronic kidney disease progression. Several PMC markers have been identified; however, heterogeneity and functions are not fully understood. Here, we describe a novel subset of renal PMCs express Meflin, glycosylphosphatidylinositol-anchored protein was recently identified as marker fibroblasts essential for cardiac tissue repair. Tracing the lineage Meflin+ PMCs, found in perivascular...
Abstract Immunocompromised patients, especially those who undergo kidney transplantation, have lower antibody levels following SARS-CoV-2 mRNA vaccination. The situation of transplant treatment, such as source and immunosuppressive drugs, is different in Japan than that other countries. Therefore, it necessary to clarify whether acquisition rates differ between This retrospective study included patients with post-kidney were attending at the Nagoya University Hospital. anti-SARS-CoV-2 IgG...
Background/Aim: Wilms9 tumor 1 (WT1) peptide-based vaccination has been reported for its potential usefulness in targeting several cancers. The adjuvant drug OK-432 is known to have potent immunomodulation and therapeutic properties when applied cancer treatment may, thus, be important trigger the appropriate immunological response paediatric patients with a solid that are vaccinated WT1 peptide. Patients Methods: Paediatric were peptide once every 2 weeks, total of seven times. Results: Of...
We have measured the concentration of cartilage-derived retinoic-acid-sensitive protein (CD-RAP) in synovial fluid (SF) from knees 49 patients with osteoarthritis (OA) and 79 rheumatoid arthritis (RA) order to investigate correlation between type joint disease level CD-RAP. The mean CD-RAP was significantly higher OA than RA. group mild moderate or severe groups that RA also other decreased progression disease. Immunohistochemical studies showed expression cytoplasm chondrocytes newly-formed...
Structural anomalies of teeth are observed at high rates in childhood cancer survivors (CCS). Several therapeutic exposures have been shown to be associated with dental developmental disturbances. This study was conducted analyze the risk factors for abnormality (DDA) and investigate association between age time treatment DDA CCS.Fifty-six CCS were enrolled. Orthopantomography examination performed all patients. We evaluated prevalence analyzed each type DDA.DDAs 46.4% CCS, including...
ABSTRACT Recent studies have indicated that total body irradiation (TBI)‐based reduced‐toxicity conditioning (RTC) may be a potential treatment modality, especially in adults with leukemia. However, its efficacy and safety children hematological malignancies remain unclear. To investigate the long‐term outcomes of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) using an 8‐Gray (Gy) TBI/fludarabine (FLU)/cyclophosphamide (CY) RTC malignancies. We included 66 consecutive...
A phase-locked-loop (PLL) concept called state-preserving intermittently locked loops (SPILL), which is suitable for the intermittent operation of frequency synthesizers used in UHF portable radio sets, proposed. SPILL uses a digital circuit technique preserves and phase during power-off periods, order to perform fast acquisition at beginning power-on periods. Both theoretical analysis experiments confirm acceptable performance. 1.6-GHz synthesizer achieves an improvement time by two orders...
Abstract Background Extracellular vesicles (EVs) have received considerable attention as ideal biomarkers for kidney diseases. Most reports focused on urinary EVs, that are mainly derived from the cells in tract. However, detection and application of kidney-derived EVs plasma remains uncertain. Methods We examined small (sEVs) were supposedly released renal mesangial glomerular endothelial cells, using clinical samples healthy controls patients with transplants. Plasma underwent...