A5015328945- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Cerebrovascular and Carotid Artery Diseases
- Gastrointestinal disorders and treatments
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Eosinophilic Disorders and Syndromes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Helicobacter pylori-related gastroenterology studies
- Pregnancy and Medication Impact
- Clostridium difficile and Clostridium perfringens research
- Esophageal and GI Pathology
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Blood Pressure and Hypertension Studies
- Genetic Neurodegenerative Diseases
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Pharmaceutical studies and practices
- Cerebrospinal fluid and hydrocephalus
- Glycogen Storage Diseases and Myoclonus
- NF-κB Signaling Pathways
National Center For Child Health and Development
2015-2025
National Institute for Japanese Language and Linguistics
2024
Juntendo University
2019-2022
Hyogo Brain and Heart Center
2007-2020
Kumamoto Medical Center
2015
University of Miyazaki
2015
Nagoya University
2013
Shimizu (Japan)
2013
Mitaka Kohki (Japan)
2013
Tokyo Medical and Dental University
2012
The mechanism of progressive neurological deficit (PND) in patients with ischemic stroke remains unclear. aim this study was to clarify whether arterial stiffness, a marker vascular endothelial impairment and arteriosclerosis, is associated PND acute deep subcortical infarction.We evaluated 156 consecutive first-ever infarction. defined as an increment ≥2 points the National Institute Health Stroke Scale score or increase ≥1 point limb weakness within 7 days onset. Patients were assessed for...
<i>Background:</i> White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis not yet clear. The aim of this hospital-based cohort study was identify arteriosclerotic characteristics associated with WMHs. <i>Methods:</i> We cross-sectionally included 240 consecutive patients no history measured brachial-ankle pulse wave velocity...
Objective The aim of this hospital-based cohort study was to clarify the independent association between silent brain infarct (SBI) and arterial stiffness indicated by brachial-ankle pulse wave velocity (baPWV) including cutoff value for SBI. Methods We studied 240 consecutive patients (mean age 69 years) with no history stroke. assessed presence SBI, white matter hyperintensities (WMHs), risk factors. Arterial evaluated using baPWV. measured intima-media thickness common carotid artery...
Abstract Background Anti-integrin αvβ6 antibody (V6Ab) has emerged as a promising diagnostic marker for differentiating ulcerative colitis (UC) from Crohn’s disease (CD) in adult. However, approximately 30% of pediatric-onset CD cases reportedly exhibited V6Ab positivity. The impact on the clinical characteristics and treatment response pediatric inflammatory bowel (IBD) remains unknown. This retrospective single-center study aimed to investigate relevance IBD pilot study. Methods We...
Tumor necrosis factor receptor-associated 3 (TRAF3) is an anti-inflammatory molecule that negatively regulates the non-canonical nuclear factor-κB pathway. Although TRAF3 haploinsufficiency (TRAF3 HI) can influence innate and adaptive immune cells, its effect on inflammatory bowel disease (IBD) development remains unclear. Here, we report first case of severe early-onset IBD with a novel variant leading to HI, successfully treated ustekinumab. A 6-year-old girl recurrent parotitis, otitis...
There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD in Japanese children and compared them with those European children.This was a cross-sectional multicenter newly diagnosed patients. The Paris classification used to categorize features, results were EUROKIDS data.A total 265 patients initially registered, 22 later excluded for having...
Abstract Background Fecal microbiota transplantation (FMT) in patients with ulcerative colitis has shown variable efficacy depending on the protocol used. A previous randomized controlled trial reported that anaerobic preparation of donor stool contributes to improved efficacy. Despite suggestion viable obligate anaerobes would be decreased through aerobic handling, there have been only a limited number reports how these or procedures affect composition fecal slurries used for FMT. Methods...
Mothers of children with very-early-onset inflammatory bowel disease (VEO-IBD) face unique challenges; however, these challenges and their consequences have not been well described. This study clarified the experiences processes empowerment mothers VEO-IBD. performed a qualitative inductive analysis using semi-structured interviews. The interview content was transcribed, generating core categories, subcategories focus on raising A modified grounded theory approach employed to inductively...
The incidence of perianal lesions (PL) in children with Crohn's disease (CD) is higher East Asia than Western countries. Early intervention for PL essential to prevent sphincter dysfunction and ostomy placement. In this study, we aimed investigate the clinical features, treatment, consequences pediatric CD PL. We retrospectively reviewed a cohort diagnosed from 2010 2020 at Japanese children's hospital. Demographics, treatments, outcomes were evaluated compared among subgroups. Among 112...
Abstract We report the case of an 11‐year‐old girl with ulcerative colitis refractory to conventional therapy, who was subsequently treated successfully repeated fecal microbiota transplantation (FMT). The patient steroid dependent despite several infliximab treatments, and colectomy proposed improve quality life. After FMT, she able maintain remission on minimal dose steroid. Although her dysbiotic before it restored a similar pattern as donor after FMT.
To evaluate the role of colonoscopy in infants and young children clarify distribution colonoscopy-requiring diseases this age group. Cohorts colonoscopies performed at three children's hospitals Japan between April 2011 March 2016 including younger than six years were retrospectively reviewed. In total, 453 276 children. Of these 275 (60.8%) for diagnostic purposes, 177 (39.2%) as follow-up, one case was treatment. The median patient time 2.49 years, there a male-to-female ratio 1.72:1....
Abstract Background and Aim Ustekinumab is a human monoclonal antibody targeting the p40 subunit of both interleukin‐12 interleukin‐23 with reported efficacy to treat Crohn's disease. However, few studies have use ustekinumab for pediatric inflammatory bowel This study aimed assess clinical safety in children adolescents Methods Medical records patients aged under 20 years disease or disease‐like who had received at Japanese center were retrospectively reviewed safety. The primary outcome...
Hereditary cerebellar ataxia constitutes a heterogeneous group of neurodegenerative disorders, occasionally accompanied by other neurological features. Genetic defects remain to be elucidated in approximately 40% hereditary cases Japan. We attempted identify the gene responsible for autosomal recessive with intellectual disability.The present study involved three patients consanguineous Japanese family. Neurological examination and analyses were performed all family members. genome-wide...
We retrospectively determined the safety and efficacy of endoscopic delivery (ED) capsule endoscopes.We enrolled 10,156 patients who underwent small bowel endoscopy (SBCE), 3182 patency (PC), 1367 colon (CCE), at 11 gastroenterological nine pediatric centers.Small endoscopies, PCs, CCEs were endoscopically delivered to 546 (5.4%), 214 (6.7%), 14 (1.0%) patients, respectively. Only mild complications occurred for 21.6% (167/774), including uneventful mucosal damage, bleeding, abdominal pain....