A5080705004- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Vasculitis and related conditions
- Diet and metabolism studies
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Screening and Detection
- Myasthenia Gravis and Thymoma
- Infant Health and Development
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- IgG4-Related and Inflammatory Diseases
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Cancer Mechanisms and Therapy
- Pericarditis and Cardiac Tamponade
- Celiac Disease Research and Management
- NF-κB Signaling Pathways
- Pregnancy and Medication Impact
- Sarcoidosis and Beryllium Toxicity Research
National Center For Child Health and Development
2020-2025
Juntendo University
2016-2023
Showa Inan General Hospital
2021
Iowa Digestive Disease Center
2020
Tumor necrosis factor receptor-associated 3 (TRAF3) is an anti-inflammatory molecule that negatively regulates the non-canonical nuclear factor-κB pathway. Although TRAF3 haploinsufficiency (TRAF3 HI) can influence innate and adaptive immune cells, its effect on inflammatory bowel disease (IBD) development remains unclear. Here, we report first case of severe early-onset IBD with a novel variant leading to HI, successfully treated ustekinumab. A 6-year-old girl recurrent parotitis, otitis...
Abstract Background Fecal microbiota transplantation (FMT) in patients with ulcerative colitis has shown variable efficacy depending on the protocol used. A previous randomized controlled trial reported that anaerobic preparation of donor stool contributes to improved efficacy. Despite suggestion viable obligate anaerobes would be decreased through aerobic handling, there have been only a limited number reports how these or procedures affect composition fecal slurries used for FMT. Methods...
The incidence of perianal lesions (PL) in children with Crohn's disease (CD) is higher East Asia than Western countries. Early intervention for PL essential to prevent sphincter dysfunction and ostomy placement. In this study, we aimed investigate the clinical features, treatment, consequences pediatric CD PL. We retrospectively reviewed a cohort diagnosed from 2010 2020 at Japanese children's hospital. Demographics, treatments, outcomes were evaluated compared among subgroups. Among 112...
Abstract Background and Aim Ustekinumab is a human monoclonal antibody targeting the p40 subunit of both interleukin‐12 interleukin‐23 with reported efficacy to treat Crohn's disease. However, few studies have use ustekinumab for pediatric inflammatory bowel This study aimed assess clinical safety in children adolescents Methods Medical records patients aged under 20 years disease or disease‐like who had received at Japanese center were retrospectively reviewed safety. The primary outcome...
Linked colour imaging is an image-enhanced endoscopy system that emphasizes the red portion of mucosa's colour. Our aim was to compare effectiveness linked with white-light colonoscopy for detection flat-type colorectal polyps.This a single-centre, randomized controlled trial. Enrolled patients were those aged ≥50 years undergoing cap-assisted cancer screening. They in 1:1 ratio observation using or colonoscopy. All polyps detected removed biopsied. The primary outcome number per patient...
Abstract Background Helicobacter pylori ( H. ) infection causes chronic gastritis, duodenal and to a lesser extent, gastric ulcers, cancer. Most infections are acquired in childhood, effective treatment of childhood is very important. Esophagogastroduodenoscopy (EGD) useful for endoscopic diagnosis, mucosal tissue biopsy, culture examination children adults. In this paper, we report results susceptibility tests eradication rates ‐positive who underwent EGD over 12‐year period. Materials...
Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in patients younger than 6 years, is a challenge for pediatric gastroenterologists. Although there have been reports regarding VEO-IBD Western countries, those Asia are still lacking. This study aimed to investigate the clinical features of Japanese patients.Patients with between 2006 and 2019 were evaluated retrospectively. The phenotypes classified into ulcerative colitis type (UC-type) Crohn's (CD-type),...
The diagnosis of Yersinia enterocolitica (Ye) enteritis is not easy because detection from stool culture more difficult for Ye than other bacterial enteritides. establishment characteristic ultrasonographic findings would help improve the rate along with performance several cold cultures. This facilitate appropriate selection antibiotics based on antimicrobial susceptibility testing and contribute to a accurate understanding local public health. study aimed retrospectively compare clinical...
Transabdominal ultrasonography [TAUS] appears comparable to colonoscopy for evaluating ulcerative colitis [UC] activity, but it has low accuracy in rectal evaluation. In this study, the of transperineal [TPUS] activity was compared that paediatric UC cases.Faecal calprotectin [FCP] values and TPUS colonoscopic findings were prospectively cases. Rectal wall thickening [RWT] flow [RWF] on power Doppler evaluated by with also measured TAUS assessed concordance rate each finding.Thirty Mayo...
Goals: The aim of this study was to evaluate the effectiveness adding a gelling agent pureed diets prevent aspiration pneumonia in elderly patients with moderate severe dysphagia. Background: Pureed are often used reduce However, ideal texture diet remains unclear. Materials and methods: We prospectively conducted randomized, crossover trial rice or without dysphagia (ClincialTrials.gov number, NCT03163355). primary outcome measure pharyngeal residuals using an endoscopic scoring system....
Long-term disease duration of ulcerative colitis (UC) is known to increase the risk developing colorectal cancer in adults; however, this association has not been genetically analyzed children with UC. Herein, we examined expression cancer-related genes colonic mucosa pediatric UC patients and their cancer.Microarray analysis gene was conducted on rectal biopsy specimens randomly selected from cases, including 4 active-phase 3 remission-phase irritable bowel syndrome control cases. The...
<b><i>Introduction:</i></b> The pathophysiology of irritable bowel syndrome (IBS) remains unknown. This study aimed to evaluate colonic motility and serotonin system response restraint stress (RS) among adolescent rats who underwent neonatal maternal separation (NMS) clarify the features pathogenesis in adolescents with IBS. <b><i>Methods:</i></b> Male were exposed NMS as chronic stress, a normally handled (NH) group was used control. Four...
A change in diagnosis from ulcerative colitis (UC) to Crohn's disease (CD) has been reported pediatric inflammatory bowel disease; however, only a few clinical characteristics and predictors of this diagnostic have reported. We aimed describe the patients with UC who underwent CD identify variables associated change.The medical records were followed up at National Center for Child Health Development between 2006 2019 retrospectively reviewed. Clinical data on phenotype, laboratory...
There is still room for improvement in the methods used to achieve complete polyp resection. The aim of this study was develop a cold snare polypectomy technique that will reliably result resections containing muscularis mucosae and lateral margins.Nonpedunculated polyps ≤10 mm were resected using dedicated with goal creating mucosal defect approximately 1 cm dia. completeness resection vertical margins examined histologically.The cases 201 patients (mean age 67 ± 13 years; 115 men) 500...
<b><i>Introduction:</i></b> Anal fistulae have a significant impact on the quality of life patients with Crohn’s disease (CD). In this cross-sectional study, we aimed to determine whether biological agents were effective in treating anal CD. <b><i>Methods:</i></b> Fifty-three diagnosed CD retrospectively enrolled. Their data regarding symptoms, treatments, and progression from January 2007 December 2016 reviewed medical records. Fifteen (28%)...
Objectives The correlation between altered small intestinal motility and irritable bowel syndrome is not well evaluated. This study aimed to assess the colonic transits in an adolescent rat model with restraint stress determine role of pathophysiology.
Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small medium-sized arteries that affects all age groups. No pediatric case bloody pericardial effusion resulting in cardiac tamponade co-existing hematochezia has been reported.A 14-year-old boy was referred for evaluation prolonged fever, chest pain, intermittent hematochezia. Diagnostic imaging showed prominent effusion. Immediately after...
新生児・乳児消化管アレルギーの1型である食物蛋白誘発性腸症は, 非IgE依存性の食物アレルギーの一つであり, 新生児期から1年以内に発症し, 嘔吐や遷延する下痢, 血便, 腹部膨満, 時に成長障害や発達障害などを呈する重篤な疾患である. 予後は良好であるが診断が困難であることも少なくないため, 早期診断や早期介入が重要である.
Abstract Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis in the upper respiratory tract, lungs, kidneys, and systemic small medium-sized arteries; adults children have similar courses. A pediatric GPA case preceding bloody pericardial effusion, which caused cardiac tamponade, stool has not been reported. Case presentation: 14-year-old boy was referred for evaluation prolonged fever. He had chest pain stools, diagnostic imaging showed effusion....
Abstract Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the colonic transits in an IBS rat model with restraint stress determine role of pathophysiology. Methods: Restraint was utilized to make adolescent models that were evaluated for clinical symptoms, including stool frequency diarrhea. transit rate also amounts mRNA encoding corticotropin-releasing hormone, mast cell, serotonin...