A5020765601- Vasculitis and related conditions
- Oxidative Organic Chemistry Reactions
- Cell Adhesion Molecules Research
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Myasthenia Gravis and Thymoma
- IgG4-Related and Inflammatory Diseases
- Synthesis and Catalytic Reactions
- Diet and metabolism studies
- Pericarditis and Cardiac Tamponade
- Heat Transfer Mechanisms
- Hypertrophic osteoarthropathy and related conditions
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Helicobacter pylori-related gastroenterology studies
- Autoimmune Bullous Skin Diseases
- Infant Health and Development
- Crystallization and Solubility Studies
- Platelet Disorders and Treatments
- Spinal Dysraphism and Malformations
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Connective tissue disorders research
- Cerebrospinal fluid and hydrocephalus
- Heat transfer and supercritical fluids
Juntendo University
2020-2023
Chiba University
2019-2023
National Center For Child Health and Development
2021
Meiji University
2015
Kyushu University
2012
Ulcerative colitis (UC) is a multifactorial chronic disorder with high prevalence worldwide. UC affects patients in all age groups; however, pediatric-onset generally more severe than adult-onset UC.1Alatab S. et al.Lancet Gastroenterol Hepatol. 2020; 5: 17-30Abstract Full Text PDF PubMed Scopus (630) Google Scholar To avoid long-term unfavorable outcomes, such as growth failure, early and proper diagnosis subsequent treatment needed for pediatric patients. Gastrointestinal endoscopy the...
SLCO2A1 encodes a prostaglandin (PG) transporter, and autosomal recessive pathogenic variants of this gene cause chronic enteropathy associated with SLCO2A1. It is unclear whether heterozygous variant has role in the pathogenesis other types inflammatory bowel disease (IBD). In study, we investigated possible involvement local epigenetic alteration patients variant.We conducted whole-exome sequencing samples from 2 sisters suspected monogenic IBD. addition, performed bisulfite using DNA...
<b><i>Introduction:</i></b> The pathophysiology of irritable bowel syndrome (IBS) remains unknown. This study aimed to evaluate colonic motility and serotonin system response restraint stress (RS) among adolescent rats who underwent neonatal maternal separation (NMS) clarify the features pathogenesis in adolescents with IBS. <b><i>Methods:</i></b> Male were exposed NMS as chronic stress, a normally handled (NH) group was used control. Four...
A change in diagnosis from ulcerative colitis (UC) to Crohn's disease (CD) has been reported pediatric inflammatory bowel disease; however, only a few clinical characteristics and predictors of this diagnostic have reported. We aimed describe the patients with UC who underwent CD identify variables associated change.The medical records were followed up at National Center for Child Health Development between 2006 2019 retrospectively reviewed. Clinical data on phenotype, laboratory...
Abstract We report a reduction‐condensation‐1,3‐dipolar cycloaddition sequence to create C2‐C3 contiguous stereogenic centers in indoline derivatives. This method includes one‐pot procedure starting from easily obtainable nitroketones and can be applied intrarmolecular give highly functionalized isoxazolidines. Both length of methylene tether olefinic substituents strongly affect the mode (exo/endo approach) stereo‐controlled tri‐ tetracyclic systems through single operation. Intermolecular...
A 2-day-old neonate presented with seizures, multiple intracranial hemorrhages, and bilateral congenital cataracts. Targeted next-generation sequencing of the collagen type IV alpha 1 chain (COL4A1) gene revealed a heterozygous de novo missense variant (NM_001845.6:c.2291G>A/p.Gly764Asp). This adds to compendium COL4A1 variants is associated COL4A1-related disorder.
Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small medium-sized arteries that affects all age groups. No pediatric case bloody pericardial effusion resulting in cardiac tamponade co-existing hematochezia has been reported.A 14-year-old boy was referred for evaluation prolonged fever, chest pain, intermittent hematochezia. Diagnostic imaging showed prominent effusion. Immediately after...
The frequency of split cord malformation (SCM) is approximately 1 in 5000 births; however, patients are rarely diagnosed with SCM the neonatal period. Moreover, there have been no reports hypoplasia lower extremities at birth. A 3-day-old girl was transferred to our hospital for a thorough examination left extremity and lumbosacral abnormalities detected after spinal magnetic resonance imaging (MRI) revealed single dural tube. Based on MRI findings, patient type II. Following discussions...
Abstract Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis in the upper respiratory tract, lungs, kidneys, and systemic small medium-sized arteries; adults children have similar courses. A pediatric GPA case preceding bloody pericardial effusion, which caused cardiac tamponade, stool has not been reported. Case presentation: 14-year-old boy was referred for evaluation prolonged fever. He had chest pain stools, diagnostic imaging showed effusion....
Abstract Background Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis in the upper respiratory tract, lungs, kidneys, and systemic small medium-sized arteries; adults children have similar courses. A pediatric GPA case preceding bloody pericardial effusion, which caused cardiac tamponade, stool has not been reported. Case presentation: 14-year-old boy was referred for evaluation prolonged fever. He had chest pain stools, diagnostic imaging showed effusion....