A5087841158- Genetic and phenotypic traits in livestock
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Reproductive Physiology in Livestock
- Animal Behavior and Welfare Studies
- Effects of Environmental Stressors on Livestock
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Metabolism and Genetic Disorders
- Gallbladder and Bile Duct Disorders
- Advanced Steganography and Watermarking Techniques
- Gastrointestinal disorders and treatments
- Milk Quality and Mastitis in Dairy Cows
- Ruminant Nutrition and Digestive Physiology
- Neonatal Health and Biochemistry
- Soybean genetics and cultivation
- Childhood Cancer Survivors' Quality of Life
- Inflammatory Bowel Disease
- Weed Control and Herbicide Applications
- Cholesterol and Lipid Metabolism
- Meat and Animal Product Quality
Juntendo University
2016-2025
Lund University
2017-2024
Juntendo University Hospital
2023
Taiho Pharmaceutical (Japan)
2023
Japan Pediatric Society
2015-2022
Obihiro University of Agriculture and Veterinary Medicine
2005-2016
Koshigaya Municipal Hospital
2012
Mitsubishi Electric (Japan)
2003-2006
Mitsubishi Group (Japan)
2005
Mitsubishi Electric (United States)
2003
NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite being among most common chronic liver diseases, biological factors responsible for its transition from benign nonalcoholic fatty (NAFL) to NASH remain unclear. This lack knowledge leads a decreased ability find relevant animal models, predict disease progression, or develop clinical treatments. In current study, we used multiple mouse models NAFLD, human correlation...
Although most bile acids (BAs) in feces are present noncovalent forms that can be extracted with ethanol, non-negligible amounts of saponifiable BAs also present. It is a major concern such routinely omitted from fecal BA measurements. We compared the profiles healthy stools were obtained with/without alkaline hydrolysis and found as much 29.7% (2.1-67.7%) total saponifiable. Specifically, treatment led to significant elevations isodeoxycholic acid (isoDCA) isolithocholic (isoLCA)...
Abstract Bile acids have received increasing attention as a marker of the long-term prognosis and potential therapeutic target in patients with biliary atresia, which is progressive disease hepatobiliary system. A detailed analysis serum urinary bile acid compositions was conducted to assess characteristics profiles correlation between liver fibrosis markers adult atresia who achieved bilirubin normalization. Serum total glucuronide-conjugated (glyco- tauro-) cholic (GCA TCA)...
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the absence leads neonatal liver failure. Disrupted with reduced hepatic expression is also found nonalcoholic steatohepatitis (NASH). The current study aimed understand regulatory mechanism mitochondrial contribution onset NASH. We used Cyp7b1
Abstract Background The lack of an accurate scoring system for pediatric acute pancreatitis could cause delays in appropriate clinical management and increase the risk progressive life‐threatening complications. We investigated a modified Ministry Health, Labour Welfare J apan ( JPN ) that uses systemic inflammatory response syndrome SIRS score, age, weight to establish more useful children. Methods A retrospective chart review was conducted patients with who were admitted untendo U...
Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppressed multiple mouse models and human cohorts. enzyme suppression leads to accumulations bioactive oxysterols such as (25R)26-Hydroxycholesterol (26HC) 25-hydroxycholesterol (25HC). We challenged transgenic...
This study aimed to evaluate the effects of psychosocial and neurodevelopmental disorders on pediatric ulcerative colitis management. Specifically, relationships between these disease severity, as well treatment strategies, were assessed through a single-center, retrospective, observational study. The included patients with (UC) under 15 years age diagnosed by colonoscopy histological evaluation January 2022 May 2024. Data comorbid functional gastrointestinal obtained from patients'...
Abstract Background Very-early-onset ulcerative colitis (VEO-UC) is a severe form of inflammatory bowel disease that manifests before the age 6 years. Compared to typical pediatric UC, it characterized by distinct genetic and immunological factors. This study aimed investigate roles specific human leukocyte antigen (HLA) alleles maternal microchimerism (MMc) in pathogenesis VEO-UC Japanese population. Methods included 27 patients, including 4 patients treated with colorectal resection. HLA...
Crude fat content of longissimus (ribeye) muscle beef cattle was predicted from a ratio area (RFA) to ribeye calculated computer image analysis (CIA). Cross sections 64 ribeyes taken the 6-7th rib at experiment station A and cross 94 Experiment Station B were used in this study. Slices (1 1.5 cm thickness) just Longissimus dorsi homogenized sampled for chemical estimation crude using petroleum ether. as determined true estimate content. CCD (charge-coupled device) camera input device A,...
We investigated the relationship between plasma insulin-like growth factor I (IGF-I), leptin, active ghrelin levels, and postnatal in very low birth weight (VLBW) infants.Plasma IGF-I, levels were measured at 2, 4, 6 8 weeks after 61 VLBW infants, including 31 appropriate-for-gestational-age (AGA) 30 small-for-gestational-age (SGA) infants.Insulin-like lowest birth, but increased gradually over first of life. IGF-I was positively correlated with body weight, length mass index all time...
Only 2 patients with an oxysterol 7α-hydroxylase deficiency caused by mutations of the cytochrome P450 7B1 (CYP7B1) gene have been reported; for both, outcome was fatal. We describe clinical and laboratory features, hepatic renal histological findings, results bile acid CYP7B1 analyses a third patient. This Japanese infant presented progressive cholestatic liver disease underwent successful heterozygous living donor transplantation. Sources relevant data included medical records,...
Abstract We examined the effects of heat stress (HS) on production traits, somatic cell score (SCS) and conception rate at first insemination (CR) in Holsteins Japan. used a total 228 242 records milk, fat protein yields, SCS for three lactations, as well CR heifers first‐ second‐lactation cows that had calved time between 2000 2012. Records from 47 prefectural weather stations throughout Japan were to calculate temperature–humidity index (THI); areas categorized into regional groups: no HS...
Although the clinical efficacy of tofacitinib has been reported in adult patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (Ab+) dermatomyositis, data on its use refractory juvenile dermatomyositis (JDM) are scarce. We describe two female Japanese anti-MDA5 Ab + JDM and rapidly progressive interstitial lung disease who achieved remission by adding to existing immunosuppressive drugs present a literature review. While both received various or...
The aim of this study was to clarify the usefulness magnetic resonance cholangiopancreatography (MRCP) for evaluation choledochal cyst in children.MRCP performed preoperatively 33 patients. MRCP findings were compared with those endoscopic retrograde or intraoperative cholangiopancreatography.In all patients, could detect cyst. detection rate a main pancreatic duct 62.2%, abnormal union pancreaticobiliary junction (AUPBJ) 53.3%, dilatation abnormalities 75.0% and protein plug stone 76.9%. In...
Causes of acute recurrent pancreatitis (ARP) or chronic (CP) are sometimes difficult to determine in children. In such patients, genetic analysis may prove helpful. The present study analyzed mutations cationic trypsinogen (PRSS1), serine protease inhibitor Kazal type 1 (SPINK1), chymotrypsin C (CTRC), and carboxypeptidase A1 (CPA1) investigated the clinical features children with these mutations.Genetic analyses 4 genes were conducted 128 patients ARP CP. Characteristics showing using...