A5039673709- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism and Genetic Disorders
- Congenital Anomalies and Fetal Surgery
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Neonatal Health and Biochemistry
- Clinical Nutrition and Gastroenterology
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
- Nuclear Physics and Applications
- Viral-associated cancers and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Folate and B Vitamins Research
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Quantum and electron transport phenomena
- Autoimmune and Inflammatory Disorders Research
- Glycogen Storage Diseases and Myoclonus
National Center For Child Health and Development
2016-2025
Organ Technologies (Japan)
2020-2021
Tottori University
2020
Juntendo University
2020
Tsuyama Chuo Hospital
2020
Saitama Medical University
2020
University of Tokyo Hospital
2018
Hyogo Medical University
2017-2018
The University of Tokyo
2001-2017
National Hospital Organization
2011-2017
The results of extension block Kirschner wire fixation for the treatment mallet fractures distal phalanx were retrospectively assessed in 65 consecutive patients. indications this technique presence a large bone fragment, and palmar subluxation or loss joint congruity interphalangeal joint. Using Wehbé Scheider classification there 27 type IB, 19 IIB, 17 IA, 2 IIA fractures. According to Crawford rating system 46% excellent, 32% good, 20% fair 2% poor results. We believe that technique, when...
Although the effectiveness of rituximab has been reported in ABO blood group (ABO)-incompatible (ABO-I) organ transplantation, protocol is not yet established. We studied impact timing prophylaxis and humoral immune response patients undergoing ABO-I living donor liver transplantation (LDLT), focusing on clinicopathological findings B-cell subset. From July 2003 to December 2005, 30 adult were treated with hepatic artery infusion (HAI) without splenectomy for LDLT. A total 17 only HAI (no...
The purpose of the current study was to assess our multidisciplinary approach consisting early application neurology-oriented intensive care, aggressive artificial liver support and transplantation at appropriate time for infants with acute failure.Retrospective cohort study.A tertiary pediatric medical center in Japan.Seventeen younger than 12 months failure who subsequently underwent between February 2006 June 2011.None.The patients varied from 1 11 months, a median 6 months. body weight...
Biliary atresia (BA) is the most common indication for liver transplantation (LT) in pediatric population. This study analyzed comprehensive factors that might influence outcomes of patients with BA who undergo living donor LT by evaluating largest cohort longest follow-up world. Between November 1989 and December 2015, 2,085 underwent LDLT Japan. There were 763 male 1,322 female recipients a mean age 5.9 years body weight 18.6 kg. The 1-, 5-, 10-, 15-, 20-year graft survival rates...
Living donor liver transplantation (LDLT) is indicated for a variety of metabolic disorders, primarily in Asian countries due to the absolute scarcity deceased (LT). We analyzed data all pediatric LDLTs performed between November 1989 and December 2010, during which 2,224 patients underwent LDLT Japan. Of these patients, 194 (8.7%) disorders. Wilson’s disease (n=59; 30.4%) was most common indication with followed by ornithine transcarbamylase deficiency (OTCD; n=40; 20.6%), methylmalonic...
Abstract Background Hepatocerebral mitochondrial DNA depletion syndrome (MTDPS) is a disease caused by defects in maintenance and leads to liver failure neurological complications during infancy. Liver transplantation (LT) remains controversial due poor outcomes associated with extrahepatic symptoms. The purposes of this study were clarify the current clinical molecular features hepatocerebral MTDPS evaluate LT patients Japan. Results We retrospectively assessed genetic findings, as well...
Reducing graft thickness is essential to prevent large-for-size problems in pediatric living donor liver transplantation (LDLT). However, long-term outcomes of LDLT using reduced-thickness left lateral segment (LLS) grafts are unclear. In 89 patients who underwent reduced LLS between 2005 and 2017, short-term were compared a nonanatomically (NAR-LLS) group group. Estimated blood loss was lower abdominal skin closure less needed the recipient operation Postoperatively, portal vein (PV) flow...
Abstract Background Excellent outcomes of the extreme procedure liver resection (LR) for advanced hepatoblastoma (HB) have been achieved in recent reports. However, transplantation (LT) remains only surgical treatment patients with unresectable HB. The aim this study was to evaluate our retrospective data cases HB necessitating intervention and analyze prognostic factors recurrence by comparing tumors resected LR LT. Patients Methods We retrospectively reviewed 24 children PRETEXT II/III/IV...
The Japanese Liver Transplantation Society (JLTS), a cooperative research consortium, was established in 1980 to characterize and follow trends patient characteristics graft survival among all liver transplant patients Japan. This study analyzed factors that may affect the current outcomes of pediatric who undergo transplantation (LT) by evaluating one largest LT cohorts world.Between November 1989 December 2018, 3347 underwent each donor recipient variant were evaluated.The procedures...
Kasahara M, Sakamoto S, Kanazawa H, Karaki C, Kakiuchi T, Shigeta Fukuda A, Kosaki R, Nakazawa Ishige Nagao Shigematsu Y, Yorifuji Naiki Horikawa R. Living‐donor liver transplantation for propionic acidemia. Abstract: Propionic acidemia is a rare autosomal recessive disorder affecting the catabolism of branched‐chain amino acids because genetic defect in PCC. Despite improvements medical treatment with protein restriction, sufficient caloric intake, supplementation l ‐carnitine, and...
AimsIn addition to their cholesterol-lowering effect, statins increase high-density lipoprotein cholesterol (HDL-C) levels. Endothelial lipase (EL) is a regulator of plasma HDL-C In the present study, effects on EL expression were investigated.
Background In the setting of liver transplantation in small infants who receive left lateral segment (LLS) grafts, problems are encountered related to graft-size mismatching form so-called “large-for-size” grafts. To address these problems, feasibility further reducing size LLS grafts hyperreduced (HRLLS) was investigated. Methods Of 175 pediatric living-donor transplantations performed between November 2005 and December 2011 at our institute, 31 cases were using HRLLS The medical records...
Liver transplantation is now an established treatment for children with end-stage liver disease. Left lateral segment (LLS) grafts are most commonly used in split and living donor children. In very small children, LLS can be too large, further nonanatomical reduction has recently been introduced to mitigate the problem of large-for-size grafts. However, implantation a infants because thickness grafts, these techniques do not address problems related thickness. We herein describe technique...
Background: Postoperative bloodstream infection (BSI) is the most important determinant of recipient morbidity and mortality after liver transplantation (LT). Children who underwent LT are at highest risk developing BSI because significant surgical intervention, use multiple devices, administration immunosuppressive agents. However, information regarding factors for in children limited. Methods: We retrospectively reviewed 210 living-donor largest pediatric center Japan. Patients’...
Abstract LT for PFIC type 1 is often complicated by postoperative diarrhea and recurrent graft steatosis. A 26‐month‐old female child with cholestatic jaundice, pruritus, diarrhea, growth retardation revealed total bilirubin 9.1 mg/dL, gamma‐glutamyl transpeptidase 64 IU /L, TBA 295.8 μmol/L. Genetic analysis confirmed ATP 8B1 defects. (segment 2, 3 graft) from the heterozygous father was performed. Biliary diversion performed a 35‐cm jejunum conduit between hepatic duct mid‐transverse...
This study assesses the safety and efficacy of hepatocyte-like cell (HLC) infusion therapy derived from human embryonic stem cells as bridging for neonatal-onset urea cycle disorders (UCD). The research includes both preclinical clinical evaluations to determine feasibility HLC a therapeutic option safer pediatric liver transplantation. Preclinical studies were conducted validate safety, biodistribution, ammonia metabolism capabilities HLCs using SCID mice models UCD extensive animal...
Liver transplantation (LT) is a well-accepted treatment for primary sclerosing cholangitis (PSC) with generally good outcomes, although recurrent PSC (rPSC) poses significant challenges. This study aimed to describe patient characteristics and identify potential risk factors of rPSC in pediatric LT recipients. retrospective analyzed 13 patients who underwent at single center. Patient characteristics, factors, outcomes were compared between those without rPSC. The median age diagnosis was 5.2...