A5064209404- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Transplantation: Methods and Outcomes
- Gallbladder and Bile Duct Disorders
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Pediatric Pain Management Techniques
- Renal and Vascular Pathologies
- Hematopoietic Stem Cell Transplantation
- Hernia repair and management
- COVID-19 Impact on Reproduction
- Hepatocellular Carcinoma Treatment and Prognosis
- Adrenal Hormones and Disorders
- Dysphagia Assessment and Management
- Teratomas and Epidermoid Cysts
- Neuroblastoma Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
National University Hospital
2011-2025
National University Health System
2021-2025
Khoo Teck Puat Hospital
2022-2024
National University of Singapore
2022-2024
University Health System
2023
National Center For Child Health and Development
2016-2018
Birmingham Children's Hospital
2007
Abstract LT for PFIC type 1 is often complicated by postoperative diarrhea and recurrent graft steatosis. A 26‐month‐old female child with cholestatic jaundice, pruritus, diarrhea, growth retardation revealed total bilirubin 9.1 mg/dL, gamma‐glutamyl transpeptidase 64 IU /L, TBA 295.8 μmol/L. Genetic analysis confirmed ATP 8B1 defects. (segment 2, 3 graft) from the heterozygous father was performed. Biliary diversion performed a 35‐cm jejunum conduit between hepatic duct mid‐transverse...
ABSTRACT Background and Aims Portal vein obstruction (PVO) is a known complication after pediatric liver transplantation (pLT). Effective management strategies are crucial in improving patient outcomes. This study investigated the various practice patterns related to PVO clarify degree of consensus on diverse facets care involved addressing pLT. Methods A self‐reported evaluation was conducted using scanned, paper‐based survey among specialized pLT centers participating Obstruction...
Ornithine transcarbamylase deficiency (OTCD) is a urea cycle disorder of X-linked inheritance, affecting the detoxification excess nitrogen and leading to hyperammonemia (hyper-NH3 ). Living donor liver transplantation (LDLT) has been applied for treatment OTCD. This case series retrospectively reviewed two OTCD patients who experienced hyper-NH3 following LDLT. The first was 5-year-old girl had onset at 2 years age. (OTC) enzyme activity 62% 15% recipient. patient suffered from recurrence...
Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices outcomes in patients with HAC LT, including early late complications.
Abstract Tacrolimus is the cornerstone of immunosuppressive therapy after pediatric liver transplantation. However, reliance on physician's experience for dose titration, coupled with tacrolimus's narrow therapeutic window and inter‐ intrapatient variability, often results in frequent under or overdosing events detrimental patient outcomes. Existing predictive personalization models are not readily feasible clinical implementation, as they require multiple measurements each day while...
Objective:Unusual clinical course Background:Bilious vomiting in a child potentially portends the dire emergency of intestinal malrotation with volvulus, necessitating prompt surgical management, differentials including small-bowel atresia, duodenal stenosis, annular pancreas, and intussusception.Although upper-gastrointestinal series (UGI) is diagnostic investigation choice, up to 15% studies are inconclusive, thereby posing challenge. Case Reports:We report case 3 children referred for...
Background Circumcision as a common elective pediatric surgery worldwide is stressful and anxiety-inducing experience for parents children. Although current perioperative interventions proved effective, such reducing preoperative anxiety, there are limited holistic solutions using mobile apps. Objective This paper aims to describe the development primary evaluation of an intelligent customer-driven smartphone-based app program (ICory-Circumcision) enhance health outcomes among children...
LT from ABO-I donors requires preconditioning regimens to prevent postoperative catastrophic AMR. NAC for HBL is known cause myelosuppression leading a reduction in the number and function of lymphocytes. We investigated this chemotherapy-induced patients listed with reference kinetics B, T cells, anti-ABO blood type isoagglutinin titers. Between 2005 2015, 319 who underwent LDLT at our institute, 12 were indicated unresectable HBL. Three are included study. Immunosuppression consisted...
Tacrolimus is a potent immunosuppressant used after pediatric liver transplant. However, tacrolimus's narrow therapeutic window, reliance on physicians' experience for the dose titration, and intra- inter-patient variability result in transplant patients falling out of target tacrolimus trough levels frequently. Existing personalized dosing models based area-under-the-concentration over time curves require higher frequency blood draws than current standard care may not be practically...