A5101720875- Inflammatory Bowel Disease
- Colorectal Cancer Surgical Treatments
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
- Surgical site infection prevention
- Cancer Research and Treatments
- Enhanced Recovery After Surgery
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Autoimmune and Inflammatory Disorders
- Stoma care and complications
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
Mie University
2011-2020
Institute of Life Sciences
2012-2019
Tsu City College
2017
Kyushu University
2009
Hôpital Saint-Antoine
2006
Sorbonne Université
2006
Assistance Publique – Hôpitaux de Paris
2006
Kyushu Tokai University
2002
Legacy Health
2001
Boston University
1988
Background: Systemic inflammation via host-tumor interactions is currently recognized as a hallmark of cancer. The aim this study was to evaluate the prognostic value various combinations inflammatory factors using preoperative blood, and assess clinical significance our newly developed score in colorectal cancer (CRC) patients. Method: In total 477 CRC patients from discovery validation cohorts were enrolled study. We assessed predictive impact for recurrence combination nine markers set,...
Neutrophil extracellular traps (NETs) represent microbial trapping and killing. Recently, it has been implicated in thrombogenesis, autoimmune disease, cancer progression. The aim of this study was to characterize NETs various organs a murine sepsis model vivo investigate their associations with platelets, leukocytes, or vascular endothelium. were classified as two distinct forms; cell-free that released away from neutrophils anchored neutrophils. Circulating characterized fragmented...
Tropomyosin-related receptor kinase B (TrkB) signaling, stimulated by brain-derived neurotrophic factor (BDNF) ligand, promotes tumor progression, and is related to the poor prognosis of various malignancies. We sought examine clinical relevance BDNF/TrkB expression in colorectal cancer (CRC) tissues, its prognostic value for CRC patients, therapeutic potential vitro vivo. Two hundred twenty-three patient specimens were used determine both BDNF TrkB mRNA levels. The these proteins their...
Abstract Background Sarcopenia frequently occurs in metastatic cancer patients. Emerging evidence has revealed that various secretory products from tumours can influence host organs and promote sarcopenia patients with malignancies. Furthermore, the biological functions of microRNAs cell‐to‐cell communication by incorporating into neighbouring or distal cells, which have been gradually elucidated diseases, including sarcopenia, elucidated. Methods We evaluated psoas muscle mass index (PMI)...
In the present study complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein was determined. This protein whose biological function is unknown consists a single polypeptide chain 276 residues including 8 tryptophan and has pyroglutamyl residue at terminus. The location two disulfide bonds in also established. three glycans, structure elucidated with aid 500 MHz 1H NMR spectroscopy, were sialylated N-biantennas. molecular weight calculated from carbohydrate 38,478, which close to...
To assess the relationship of C-reactive protein/albumin ratio (CAR) to outcomes and surgical site infection (SSI) in gastric cancer (GC) treated with curative intent, we retrospectively assessed 384 patients GC for CAR, SSIs, disease-free survival (DFS), overall (OS) other factors. We found SSIs 42 (10.9%). Pathological T-stage, TNM classification, body mass index, duration surgery, blood loss preoperative CAR were significantly associated SSIs; multivariate analyses, [hazard (HR)=2.98,...
Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on (ADAR) enzymes. Recent evidence suggests that of antizyme inhibitor 1 (AZIN1) emerging as a key epigenetic alteration underlying cancer pathogenesis.We evaluated AZIN1 levels, and the expression its regulator, ADAR1, in 280 gastric tissues from 140 patients, using site-specific quantitative polymerase chain reaction assays. We also analyzed clinical significance these results disease biomarkers (GC)...
To identify predictors of poor prognosis patients with colon cancer (CC) who underwent surgery curative intent, we investigated the association between albumin to globulin ratio (AGR) clinicopathological findings such as overall (OS) and disease-free (DFS) survival.We conducted a retrospective study findings, including preoperative laboratory data, for 248 stage I-III CC.Patients low AGR had shorter DFS OS compared those high AGR. Multivariate analyses identified an independent variable...
Tropomyosin-related receptor kinase B (TrkB) promotes proliferation and invasion, relating to poor prognosis of various malignancies. We examined the role TrkB at invasive front gastric cancer (GC) its association with tumour cell dedifferentiation budding. Immunoreactive was evaluated centre margin using whole-tissue sections 320 GC patients. Tumour defined as higher histologic grade than surface or centre. budding also scored on cytokeratin-stained sections. Sixty-five patients (20%)...
Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal anti-inflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual uncommon type enteritis referred to the condition as chronic nonspecific multiple small intestine [CNSU]. CNSU is characterised blood protein loss through persistent ulcers. Recently, four candidate mutations in solute carrier organic anion...
Abstract Background Sarcopenia is defined as the loss of skeletal muscle mass, accompanied by decreased strength, and consists myopenia myosteatosis. Recent evidence has suggested predictive value sarcopenia for risk perioperative oncological outcomes in various malignancies. The aim this study was to clarify clinical impact myosteatosis colorectal cancer (CRC) patients. Methods We analyzed preoperative psoas mass index intramuscular adipose tissue content using computed tomography images...
Abstract Background The systemic inflammatory response (SIR) via host‐tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression cancer cachexia. objective this study was to clarify correlation between sarcopenia in patients with colorectal (CRC). Methods A total 308 CRC were enrolled study. Preoperative psoas muscle mass index intramuscular adipose tissue content evaluated using preoperative...
Abstract Background Malnutrition can adversely affect treatment responses and oncological outcomes in cancer patients. However, among patients with rectal who undergo chemoradiotherapy (CRT), the significance of peri‐treatment nutrition assessment as a predictor response outcome remains unclear. Objective The aim this study was to determine whether Prognostic Nutrition Index (PNI) based on serum be used CRT. Design, Setting, Patients We analyzed 114 received preoperative CRT followed by...