A5091352591- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Diagnosis and treatment of tuberculosis
- Child Nutrition and Feeding Issues
- Airway Management and Intubation Techniques
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Escherichia coli research studies
- Stress Responses and Cortisol
- Foreign Body Medical Cases
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- Gastroesophageal reflux and treatments
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Biliary and Gastrointestinal Fistulas
- Infection Control and Ventilation
- Hormonal Regulation and Hypertension
- Neutropenia and Cancer Infections
Osaka Women's and Children's Hospital
2021-2025
Saitama Prefecture
2018-2024
Saitama Children's Medical Center
2009-2020
Osaka International Cancer Institute
2019
University of California, San Francisco
2017-2019
Cedars-Sinai Medical Center
2016
Kitasato University
2001
Pediatric gastrointestinal (GI) endoscopy significantly contributes to the diagnosis and management of GI diseases in children. Global data on pediatric Asia-Pacific region are limited. We aimed report findings a regional survey region. A questionnaire-based involving centers 13 countries (June November 2021). The questionnaires included annual procedure volumes (from basic diagnostics advanced therapeutic endoscopy), endoscopists, sedation procedures, national training programs. total 162...
Functional dyspepsia (FD) is a chronic disorder characterized by upper abdominal symptoms in the absence of an identifiable organic cause. Although efficacy acotiamide has been demonstrated adults with FD, its effectiveness pediatric patients remains unclear. This study aimed to evaluate FD. We conducted retrospective analysis 33 aged <16 years, who received at single children's hospital between August 2013 and March 2022. Symptomatic improvement was observed 57.6% (19/33) one month after...
Objective. To assess anxiety among pediatric patients and their parents related to initial gastrointestinal endoscopy. Methods. Patients aged <19 years undergoing (GI) endoscopy were invited complete a self-administered questionnaire in 13 institutions Japan. Results. The subjects 128 children, 1 month 17 years. Forty-eight (37.5%) underwent esophagogastroduodenoscopy (EGD), 32 (25%) colonoscopy (CS), 39 (30.5%) both EGD CS, 3 (2.3%) balloon enteroscopy (BE), capsule (CE), CE other...
There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD in Japanese children and compared them with those European children.This was a cross-sectional multicenter newly diagnosed patients. The Paris classification used to categorize features, results were EUROKIDS data.A total 265 patients initially registered, 22 later excluded for having...
Chronic stress is a major contributor in the development of metabolic syndrome and associated diseases, such as diabetes. High-fat diet (HFD) sex are known modifiers parameters. Peptide hormones corticotropin-releasing factor (CRF) urocortins (UCN) mediate responses via activation feedback to hypothalamic-pituitary-adrenal (HPA) axis. UCN3 marker pancreatic β-cell differentiation, UCN2 ameliorate glucose levels mice rendered diabetic with HFD. CRF receptor 2 (CRF2) only cognate for UCN2/3....
To evaluate the role of colonoscopy in infants and young children clarify distribution colonoscopy-requiring diseases this age group. Cohorts colonoscopies performed at three children's hospitals Japan between April 2011 March 2016 including younger than six years were retrospectively reviewed. In total, 453 276 children. Of these 275 (60.8%) for diagnostic purposes, 177 (39.2%) as follow-up, one case was treatment. The median patient time 2.49 years, there a male-to-female ratio 1.72:1....
We recently generated a monoclonal antibody immunoglobulin G1 (MAb 10G5), which can recognize 15- to 17-kDa antigens, virulence-associated antigens of Rhodococcus equi, and developed colony blot enzyme-linked immunosorbent assay with MAb 10G5 for the rapid identification virulent R. equi. In this epidemiologic study, we evaluated results test in isolates equi from feces horses soil compared them those conventional procedure (plasmid profiles by agarose gel electrophoresis). Environmental...
Few studies of zinc monotherapy for presymptomatic Wilson disease have focused on young children. We therefore evaluated long-term efficacy and safety such children established benchmarks maintenance therapy.We retrospectively prospectively examined under 10 years old with who received from time diagnosis at 12 participating pediatric centers in Japan.Twenty-four patients met entry criteria. Aspartate aminotransferase alanine decreased significantly beginning 1 month after initiation...
Prostaglandin E-major urinary metabolite (PGE-MUM) is a useful biomarker for adult ulcerative colitis (UC) activity. In the present study, we evaluated whether PGE-MUM can also be of pediatric UC activity and compared its efficacy in predicting with that C-reactive protein erythrocyte sedimentation rate.Twenty-nine patients (8-18 years) 29 healthy age- sex-matched subjects were enrolled. was using Pediatric Ulcerative Colitis Activity Index, highest Mayo endoscopic scoring (Mayo), Matts...
Extracellular vesicles (EVs) are composed of bilayer membranes that released by different cell types and present in bodily fluids, such as blood, urine, bile. EVs thought to play a key role intracellular communication. Based on their size density, classified into small, medium, or large EVs. Cargo composition reflects physiological changes health disease. Patients with irritable bowel syndrome (IBS) exhibit visceral hypersensitivity mood disorders. Stressful episodes often precede disease...
Abstract Prostaglandin E-major urinary metabolite (PGE-MUM) is a biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic (HR) pediatric UC (6–16 years) comparison with fecal calprotectin (FCP). ER HR were defined as Mayo score (MES) 0 Matts’ histological grades (Matts) 1 or 2, respectively. A total 104 39...
Early onset pediatric ulcerative colitis (EO-UC) is distinguished from late-onset (LO-UC) by the effects of genetic predisposition, but there have been few reports on clinical features EO-UC in Asia.To describe and compare presentation disease course (age range, 0-7 years) with those LO-UC 8-15 years), we retrospectively analyzed 63 children UC who had diagnosed between January 2004 March 2014 at Saitama Children's Medical Center Japan.Ten patients (16%) EO-UC, 53 (84%) LO-UC. All group 70%...
Immunosuppressive therapies can affect the immune response to or safety of vaccination in patients with inflammatory bowel disease (IBD). The appropriateness should be assessed prior initiation IBD treatment because frequently undergo continuous immunosuppressive drugs. This consensus was developed support decision-making process regarding appropriate for pediatric and adult physicians by providing critical information according published literature expert about vaccine-preventable diseases...
Peliosis hepatis (PH) is a rare condition of unknown pathogenesis, presenting with multiple cystic blood-filled spaces throughout the liver and spleen parenchyma. PH usually associated chronic pathological conditions, such as tuberculosis, fibrosis, human immunodeficiency virus infection, prolonged use medications, including anabolic steroids. In children, several cases X-linked myotubular myopathy (XLMTM) have been reported (1,2). XLMTM congenital characterized by presence central nuclei in...
The benefit of balloon-assisted enteroscopy (BAE) had been recently documented in pediatric patients, but previous reports are based on single institution experiences. We evaluated the feasibility BAE 8 tertiary referral hospitals throughout Japan.This was a prospective, multi-institutional study. Patients younger than 18 years were enrolled between April 2014 and March 2017 to undergo double-balloon or single-balloon enteroscopy. Data collected prospectively using standardized...
Abstract Background Vedolizumab (VDZ) is a humanized monoclonal antibody that binds to α4β7 integrin expressed in T‐lymphocytes and gut selective. Few studies have evaluated the safety efficacy of VDZ pediatric ulcerative colitis (UC) patients, especially from Asia. Methods A longitudinal multicenter retrospective study was conducted at 10 Japanese tertiary medical institutions. Patients aged ≤18 years old who received for UC between January 2019 July 2021 were enrolled. Information on...
Abstract Background It is important to assess pediatric patients for nutritional deficiency when they are receiving specific interventions, such as enteral feeding. We focused on measurement of C0 and 3‐hydroxyisovalerylcarnitine (C5‐ OH ) with tandem mass spectrometry ( MS / ), which performed part the newborn screening. The purpose this study was investigate usefulness screening carnitine biotin deficiencies. Methods Forty‐two children (24 boys, 18 girls) were enrolled between December...
Shwachman-Diamond syndrome (SDS) is a rare, inherited, autosomal recessive disease characterized by exocrine pancreatic dysfunction, skeletal problems and varying degrees of cytopenias resulting in bone marrow dysfunction. We report the first case SDS that was difficult to distinguish from celiac because this valuable example variety presentation.