A5085854031- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Thyroid Disorders and Treatments
- Supercapacitor Materials and Fabrication
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Multiple and Secondary Primary Cancers
- Ovarian function and disorders
- Ion channel regulation and function
- Molecular spectroscopy and chirality
- Retinoids in leukemia and cellular processes
- Pancreatic function and diabetes
- Metastasis and carcinoma case studies
- Diet and metabolism studies
- Cephalopods and Marine Biology
- Biliary and Gastrointestinal Fistulas
- Bacterial Identification and Susceptibility Testing
- Ion Transport and Channel Regulation
- Pneumothorax, Barotrauma, Emphysema
Keio University
2015-2024
Ijinkai Takeda General Hospital
2024
Fukushima Medical University
2024
Nagoya Medical Center
2017
National Hospital Organization
2017
Tokyo Institute of Technology
2016
Hokkaido University Hospital
2010
Nippon Medical School
2001-2009
Gunma University
1983-2004
Tokyo University of Agriculture and Technology
1995
Gonadotrophin‐releasing hormone (GnRH) neurones represent the final output in neuroendocrine control of reproduction, and γ‐amino butyric acid (GABA) is one major players regulation GnRH neurones. GABA inhibits a large proportion brain adult animals by acting on A‐type receptors (GABA A Rs). Two contradictory reports action mice have been published. DeFazio et al. ( Mol Endocrinol 2002; 16 : 2872) demonstrated that activation Rs excites mice, whereas Han Endocrinology 143 1459) showed...
1. Changes in intracellular ionized calcium [Ca2+]i induced by human growth hormone releasing factor (hGRF) were analysed quantitative fluorescent microscopy using a dual‐wavelength, ratiometric video imaging system and low light level charge‐coupled device (CCD) camera visualizing Fura‐2 dispersed male rat anterior pituitary cells. 2. In cells responding to hGRF, spontaneous basal oscillations frequently observed, these usually characterized gradient of localized the subplasmalemmal region...
In November 1992 and June August 1993 rectal contents from 204 small mammals living in the wild were collected examined for presence of Yersinia enterocolitica serovar O:8 to clarify source human infections caused by this microbe Tsugaru Region Aomori Prefecture, Japan. Serovar was isolated 10 (5.2%) 193 rodents trapped (9 107) (1 23) but not animals (0 63). This 11 moles. From May September 1993, 12 patients found have become ill be infected with Y. O:8. The lived same districts where...
We recently generated a monoclonal antibody immunoglobulin G1 (MAb 10G5), which can recognize 15- to 17-kDa antigens, virulence-associated antigens of Rhodococcus equi, and developed colony blot enzyme-linked immunosorbent assay with MAb 10G5 for the rapid identification virulent R. equi. In this epidemiologic study, we evaluated results test in isolates equi from feces horses soil compared them those conventional procedure (plasmid profiles by agarose gel electrophoresis). Environmental...
To further clarify the ionic mechanism of action growth hormone (GH)-releasing factor (hGRF) on GH secretion, involvement extracellular Na+ was studied in perifused dispersed rat anterior pituitary cells. Replacing with mannitol or tris(hydroxymethyl)aminomethane (Tris+) suppressed hGRF- and dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP)-induced secretion. The peak responses to a 2-min application 1 nM hGRF were 165.0 +/- 5.6 ng/ml (normal medium, mean SE), 21.2 1.4 (Na+-free,...
Non-small cell lung cancer (NSCLC) occasionally develops in younger, fertile patients. This early-onset NSCLC tends to have more oncogenic driver mutations than aged Among patients, pregnancy is very rare. However, there are some patients who were able balance tyrosine kinase inhibitor (TKI) administration and pregnancy. Here, we report a case of under alectinib hydrochloride (a second-generation anaplastic lymphoma (ALK)-TKI) throughout the entire gestational period for ALK
An electric double‐layer capacitor (EDLC), which is one of the pivotal energy storage devices, provides rapid charge–discharge capabilities and an extended cycle life. Areal capacitance, a key indicator EDLC performance, increases with specific surface area its electrodes. This study demonstrates method for significantly increasing in laser‐induced graphitization biodegradable polymers by incorporating NaHCO 3 into composite sheet, generating not only microscale pores but also large number...
The effect of human growth hormone-releasing hormone (hGHRH), a potent stimulator adenylate cyclase in somatotrophs on the voltage-gated sodium current was determined by perforated patch clamp cultured rat amplitude augmented 65.3 +/- 20.6% (mean SE, n = 7) 10 nM hGHRH. This augmentation reversibly blocked microM H-89 specific inhibitor for adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase. membrane-permeant analogue cAMP, dibutyryl cAMP (5 mM), also 39.6 7.4% (n 10)....
Abstract Pituitary folliculo‐stellate cells (FSCs) are glia‐like in the anterior pituitary and believed to modulate activity of endocrine cells. However, little is known what regulates FSCs. We hypothesized that ATP could act on FSCs, because coreleased with hormones from To test this possibility, we examined effect by measuring intracellular Ca 2+ concentration [Ca ] i FSCs primary culture. Both UTP increased a concentration‐dependent manner range between 0.1 µ M 10 . The response was...
Several observations have been made on the mechanism of human growth hormone-releasing factor (hGRF)-induced hormone (GH) secretion. 1) hGRF activates adenylate cyclase and production adenosine 3',5'-cyclic monophosphate (cAMP). 2) Extracellular Ca2+ is indispensable in both hGRF- excess K+-induced GH 3) Na+ also essential hGRF-induced but not 4) Both are required dibutyryl (DBcAMP)-induced Thus may increase conductance via cAMP, which turn depolarizes somatotrophs voltage-sensitive...
Application of L-glutamate (L-glu) to particular neurons (G-H cells) in the esophageal ganglia Onchidium produced hyperpolarization associated with an increase K+ permeability. The reversal potential (Erev) for this response, was -60 mV. ED50, indicator affinity between L-glu and its receptive site, 5.3 mM, Hill coefficient n, cooperativity, 2. Other chemicals, structurally analogous L-glu, were also examined on G-H cells. responses L-aspartate similar those respect Erev, n. However, cells...
Abstract Folliculo‐stellate cells of the anterior pituitary are thought to modulate hormone secretion through a paracrine mechanism. Angiotensin II and adenylate cyclase‐activating polypeptide (PACAP) have previously been shown increase intracellular Ca 2+ concentration ([Ca ] i ) these cells. In present study, we examined effects various peptides such as bradykinin, angiotensin II, endothelin‐1, PACAP, galanin neurotensin by ‐imaging folliculo‐stellate in primary culture. Bradykinin...
To investigate the neural mechanism involved in suppression of GH secretion, we examined effect electrical stimulation midbrain central gray (CG) and several raphe nuclei on human (h) GRF-induced secretion pentobarbital-anesthetized rats. A concentric bipolar stimulating electrode was implanted stereotaxically into each nucleus under pentobarbital anesthesia 1 week before stimulation. Blood samples were taken through a cannula placed right atrium via external jugular vein. Under anesthesia,...
The electric double-layer capacitor (EDLC) is an energy storage device distinguished by its relatively extended cycle life and rapid charge-discharge capabilities. Heightened capacitance of the EDLC aligns with augmented specific surface area electrodes. In this study, we employed laser-induced graphitization a biodegradable composite sheet containing NaHCO3 to fabricate conductive porous carbon structures serving as Pores were observed on after laser irradiation. It considered that...
A 42-year-old woman with early-stage cancer of the esophagogastric junction was admitted to our hospital for treatment. Ambulatory endoscopic examination revealed a round, elevated lesion, 6 × 5 mm in size, reddish surface on top 2-cm polyp ([Fig. 1]) and evidence gastroesophageal reflex disease (GERD).