A5019678191- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Retinoids in leukemia and cellular processes
- Neuroscience and Neuropharmacology Research
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Mitochondrial Function and Pathology
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Per- and polyfluoroalkyl substances research
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Reproductive System and Pregnancy
- Neuroendocrine regulation and behavior
- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Carcinogens and Genotoxicity Assessment
- Nerve injury and regeneration
- Pharmacogenetics and Drug Metabolism
Gunma University
2016-2025
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2025
National Institute of Technology, Gunma College
2025
Integra (United States)
2019
Harvard University
1997-2015
National Hospital Organization Takasaki Medical Center
2014
Japanese Society of Physiological Anthropology
2013
Monash University
2013
Emory University
2013
Integrative Medicine Institute
2013
Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that regulate target gene transcription. We report the molecular cloning and characterization of a novel human cDNA encoding TRAM-1, athyroid receptor activatormolecule, ∼160-kDa protein homologous with SRC-1/TIF2, by far-Western-based expression screening. TRAM-1 binds to thyroid (TR) other NRs in manner enhances ligand-induced transcriptional activity TR. The AF-2 region has been thought play critical role mediating...
Feeding behavior is controlled by various neural networks in the brain that are involved different feeding phases: Food procurement, consumption, and termination. However, specific circuits controlling food consumption phase remain poorly understood. Here, we investigated roles of dopaminergic neurons paraventricular nucleus hypothalamus (PVH) mice. Our results indicated PVH were critical for extending development obesity through epigenetic mechanisms. These synchronized with...
Polychlorinated biphenyls (PCBs) are environmental compounds that disrupt the endocrine system, and exposure to low doses causes abnormalities, particularly in developing central nervous system. Because they structurally similar thyroid hormone (TH), PCBs might affect systems involving this hormone. We previously found, using reporter assays, hydroxylated-PCB at as 10–10m suppress TH-induced transcriptional activation of TH receptor (TR). To understand molecular mechanisms process, we...
To effectively direct targeted repression, the class I histone deacetylases (HDACs) associate with many important regulatory proteins. In this paper we describe molecular characterization of a member Jumonji domain 2 (JMJD2) family proteins, and demonstrate its binding to both HDACs retinoblastoma protein (pRb). JMJD2 proteins are characterized by presence two leukemia-associated protein/plant homeodomain (LAP/PHD) zinc fingers, one JmjN, JmjC (containing an internal retinoblastoma-binding...
Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain of great health concern.We investigated effect PBDEs/hydroxylated PBDEs (OH-PBDEs) on thyroid hormone (TH) receptor (TR)-mediated transcription TH-induced dendrite arborization cerebellar Purkinje cells.We examined PBDEs/OH-PBDEs TR action using transient transfection-based reporter gene assay. TR-cofactor binding was...
Steroid and xenobiotic receptor (SXR) is activated by endogenous exogenous chemicals including steroids, bile acids, prescription drugs. SXR highly expressed in the liver intestine, where it regulates cytochrome P450 3A4 (CYP3A4), which turn controls steroid hormone metabolism. However, unclear whether Food Drug Administration (FDA)-approved plasticizers exert such activity. In present study, we evaluated effects of FDA-approved on SXR-mediated transcription vitro luciferase reporter,...
Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children adulthood. On the other hand, widely known as phytoestrogens that exert their action via estrogen signaling pathway. With this regard, also endocrine-disrupting chemicals. Endogenous plays crucial role in brain development through binding receptors (ERs) or G protein-coupled 1 (GPER1) regulates morphogenesis, migration, functional maturation, intracellular...
There is increasing concern about endocrine-disrupting chemicals (EDCs) which may produce adverse health effects in humans and other species. One such chemical, bisphenol-A (BPA), a monomer of polycarbonate plastics, widely used consumer products; it has been reported to contain estrogenic activity through binding estrogen receptors. Cytochrome P450 mono-oxygenase 3A4 (CYP3A4) one the key enzymes for metabolism endogenous steroids foreign liver. The orphan nuclear receptor, steroid...
Cytochrome P450 monooxygenase 3A4 (CYP3A4) is responsible for the metabolism of endogenous steroids and drugs in liver. Many inducers human CYP3A4, such as rifampicin, bind to orphan nuclear receptor SXR (steroid xenobiotic receptor) ligands stimulate transcription on response elements located CYP3A4 promoter. Conversely, it not known whether mediates transcriptional repression. We thus examined repression its interaction with corepressors, NCoR (nuclear corepressor) SMRT (silencing mediator...
The aim of this study was to examine the effects perinatal exposure gadolinium (Gd)-based contrast agents (GBCAs) on behavior adulthood offspring.Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear or vehicle from pregnancy day 15 19, corresponding embryonic 19 fetus, at 2 mmol/kg body weight day. Brain samples dams and pups collected postpartum 28. total Gd concentration quantified by...
After ischemic stroke, the corresponding area contralateral to lesion may partly compensate for loss of function. We previously reported remodeling neuronal circuits in somatosensory cortex (SSC) during first week after infarction processing bilateral information, resulting functional compensation. However, underlying processes hemisphere stroke have not yet been fully elucidated. Recent studies shown that astrocytes play critical roles synaptic reorganization and compensation a stroke....
Early-life stress may cause several neuropsychological disorders in adulthood. Such be induced as a result of instability neuronal circuits and/or synaptic formation. However, the mechanisms underlying such have not yet been clearly understood. We previously reported that mushroom spine somatosensory cortex (SSC) is unstable early-life stressed mice only juvenile stage but also In this study, we measured number and motility microglial processes to understand mechanism further. found...
Significance Maternal child neglect is an increasingly prevalent public health issue, but the underlying biologic processes causing this phenomenon are still largely unknown. This study examines prenatal environment of mice that later exhibit neglectful behavior. We have found that, in mice, factors determining phenotype a mother present during her own fetal period. evidence maternal prolactin (PRL) could be key factor for generating nurturing behavior offspring by activating neural circuits...
Thyroid hormones play crucial roles in the development and functional maintenance of central nervous system. Despite extensive studies neural function thyroid hormones, little is known about effects hypothyroidism on behavioural traits mechanisms underlying such effects. In present study, we report an investigation congenitally hypothyroid mutant rdw rats, revealing a novel The rats were subjected to analyses as rotarod test, open field test circadian activity measurement. To determine cause...