A5002953580- Cancer-related Molecular Pathways
- Atrial Fibrillation Management and Outcomes
- Ubiquitin and proteasome pathways
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Digestive system and related health
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Food composition and properties
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Antibiotic Use and Resistance
- Phytoestrogen effects and research
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Stress Responses and Cortisol
- Cytokine Signaling Pathways and Interactions
- Urinary and Genital Oncology Studies
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Traumatic Ocular and Foreign Body Injuries
- Tea Polyphenols and Effects
- Cancer, Stress, Anesthesia, and Immune Response
Nihon University
2015-2025
Keio University
2025
Fukuoka University
2011-2024
Physiol (Belgium)
2019-2023
Aichi University
2022-2023
Tokyo University of Science
2021-2022
University of California, Los Angeles
1993-2021
Aichi Medical University
2018-2021
National Center for Global Health and Medicine
2020-2021
Institute of Forensic Science
2021
MicroRNAs (miRNAs) are endogenous small RNAs of 21-25 nucleotides that can pair with sites in 3' untranslated regions mRNAs protein-coding genes to downregulate their expression. Recently, circulating miRNAs have been reported as promising biomarkers for various pathologic conditions. We assessed the hypothesis may leak into blood from injured cells and thereby serve identifying cell type.We used isoproterenol-induced myocardial injury rats a model miRNA array analyses identify candidate...
To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy couples expression array-based detection of environmentally responsive transcription in silico discovery regulatory polymorphisms predict loci modulate transcriptional responses stressful environments. Tests one predicted interaction locus the IL6 promoter (SNP rs1800795) verified it modulates response beta-adrenergic activation GATA1 factor vitro. In vivo validation...
This study aimed at determining whether oral administration of a probiotic strain, Lactobacillus casei strain Shirota (LcS), can improve insulin resistance, which is the underlying cause obesity-associated metabolic abnormalities, in diet-induced obesity (DIO) mice.DIO mice were fed high-fat diet without or with 0·05% LcS for 4 weeks and then subjected to an tolerance test (ITT) glucose (OGTT). Oral not only accelerated reduction plasma levels during ITT, but also reduced elevation OGTT. In...
Several studies have demonstrated that the daily intakes of soy foods were associated with a reduced cardiovascular risk. The aim our study was to investigate inhibitory effect black soybeans on low density lipoprotein (LDL) oxidation in comparison yellow soybeans. extract from soybean had longer LDL lag time than (205 +/- 16 and 65 3 min, respectively). When both divided into seed coat mixture germ cotyledon, diluted solution prolonged significantly more original coat. On other hand,...
MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for diseases. In this study, miRNA array analysis tissues showed miR-124 is almost exclusively expressed the central nervous system and neuronal cells, suggesting it might be useful a potential biomarker neurological We examined whether concentrations of brain-specific can serve cerebral...
Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing stress, but mechanism(s) by which this cytokine is regulated its role growth remain under investigation. Here we show hormones such as norepinephrine lead increased expression IL-6 mRNA protein carcinoma cells. Furthermore, demonstrate stimulation activates...
Previous studies have suggested that the BH3 domain of proapoptotic Bcl-2 family member Noxa only interacts with anti-apoptotic proteins Mcl-1 and A1 but not Bcl-2. In view similarity binding domains these as well recent evidence isolated can potentially underestimate between full-length members, we examined interaction human members. Surface plasmon resonance using bacterially expressed demonstrated binds mean dissociation constants (K(D)) 3.4 nm for Mcl-1, 70 Bcl-x(L), 250 wild type Bcl-2,...
Background Recent large-scale genome-wide association studies have identified several loci associated with the risk of coronary artery disease (CAD). The aim present study was to examine whether previously reported CAD-associated single-nucleotide polymorphisms (SNPs) confer susceptibility myocardial infarction (MI) in a population 2,475 controls and 589 cases MI. effect SNPs on cardiovascular factors control group also investigated. Methods Results Significant associations were observed...
Total syntheses of (+)-cytisine, (−)-kuraramine, (−)-isokuraramine, and (−)-jussiaeiine A were achieved via a samarium diiodide-promoted reductive deamination reaction, followed by simultaneous recyclization proline derivative to give the corresponding δ-lactam derivative, as key step.
Abstract Although numerous therapeutic strategies have attempted to target aerobic glycolysis inhibit tumor progression, these approaches not resulted in effective clinical outcomes. Murine squamous cell carcinoma (SCC) can be initiated by hair follicle stem cells (HFSCs). HFSCs utilize glycolysis, and the activity of lactate dehydrogenase (Ldh) is essential for HFSC activation. We sought determine whether Ldh SCC critical tumorigenesis or simply a marker type origin. Genetic abrogation...
Abstract We conducted two online surveys about antibiotics targeted at the Japanese general population in March 2017 and February 2018. In total, 6,982 participants completed questionnaire. Factors associated with knowledge of antibiotics, antimicrobial resistance (AMR) appropriate behavioural changes were evaluated by a machine learning approach using DataRobot. strongly three dependent variables model extracted based on permuation importance. found that strongest determinant AMR was...
Objective: Green tea was shown to inhibit LDL oxidation, platelet aggregation, and matrix metalloproteinases (MMPs) activities in vitro. We tried elucidate whether or not green consumption may have these effects vivo, which be protective against atherosclerotic disease.Methods: measured serum malondialdehyde-modified (MDA-LDL) concentrations urine 8-epi-prostaglandin (PG) F2α 22 healthy male nonsmokers. They drank 7 cups/day of water for 2 weeks the next weeks. Regarding plasma thromboxane...
Hepatic triglyceride (TG) accumulation is considered to be a prerequisite for developing nonalcoholic fatty liver (NAFL). Peroxisomes have many important functions in lipid metabolism, including acid β-oxidization. However, the pathogenic link between NAFL and peroxisome biogenesis remains unclear. To examine molecular physiological of Pex11α gene, we disrupted this gene mice. Body weights hepatic TG concentrations Pex11α(-/-) mice were significantly higher than those wild-type (WT) fed...
We examined the effect of L-lactic acid on calcium absorption in male Wistar rats made achlorhydric by dietary omeprazole, a proton pump inhibitor. The omeprazole intake (0.03 g/100 g diet) increased gastric pH and decreased apparent ratio. Dietary famotidine diet), an H2-receptor antagonist, lower doses (0.005 or 0.01 did not affect absorption. In second experiment, lactic (0.5, 1.0, 2.5 intestinal dose dependently fed diet). was significantly only higher (1.0, third sour milk beverage...