A5101834993- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Neuroscience of respiration and sleep
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Cardiac and Coronary Surgery Techniques
- Thermal Regulation in Medicine
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Pulmonary Hypertension Research and Treatments
- Sepsis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Trauma Management and Diagnosis
- Esophageal Cancer Research and Treatment
Noguchi Hospital
2018-2024
The Japanese Society of Intensive Care Medicine
2020
Ibiden (Japan)
2020
Nippon Medical School Hospital
2002-2016
Kyoto Medical Center
2016
Nippon Medical School
2005-2015
Takeda (United States)
2009
Takeda (Japan)
1997-2008
Ministry of Education, Culture, Sports, Science and Technology
2003
Abstract Introduction Fever is frequently observed in critically ill patients. An independent association of fever with increased mortality has been non-neurological patients mixed febrile etiology. The and antipyretics mortality, however, may be different between infective non-infective illness. Methods We designed a prospective observational study to investigate the use antipyretic treatments without sepsis. included 1,425 consecutive adult (without neurological injury) requiring > 48...
In Brief BACKGROUND: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect dexmedetomidine in patients NIV. METHODS: This was a prospective clinical investigation an intensive care unit. Dexmedetomidine infused 10 whom NIV difficult because agitation. RESULTS: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 ± 0.94 −1.23 1.30, respectively. All successfully weaned from NIV, respiratory state not worsened. CONCLUSION:...
Background Underlying mechanisms behind opioid-induced respiratory depression are not fully understood. The authors investigated changes in burst rate, intraburst firing frequency, membrane properties, as well presynaptic and postsynaptic events of neurons the isolated brainstem after administration opioid receptor agonists. Methods Newborn rat brainstem-spinal cord preparations were used superfused with mu-, kappa-, delta-opioid Whole cell recordings performed from three major classes...
To evaluate procedures and outcomes of extracorporeal membrane oxygenation (ECMO) therapy applied to 2009 influenza A(H1N1) severe respiratory failure patients in Japan.This observational study used database information about adults who received ECMO for H1N1-related from April 1, 2010 March 31, 2011.Fourteen 12 facilities were enrolled. Anti-influenza drugs all cases. Before the start ECMO, lowest PaO(2)/FiO(2) was median (interquartile) 50 (40-55) mmHg, highest peak inspiratory pressure 30...
Cardiogenic pulmonary edema is a frequent cause of reparatory failure. We investigated the effects nasal continuous positive airway pressure (CPAP) in patients with severe associated acute myocardial infarction. Twenty-nine consecutive were divided into 3 groups: firstly, 7 intubated who received mechanical ventilation at study entry comprised intubation group. The rest randomly assigned to either following 2 11 oxygen plus CPAP delivered by mask (CPAP group), and only via face (oxygen...
To examine the association between decreased release of proinflammatory cytokines in response to urinary trypsin inhibitor pretreatment and myocardial lung injury after cardiopulmonary bypass.A prospective, randomized, double-blind study.University hospital.Thirty patients on bypass undergoing coronary artery grafting.Patients received 5000 units/kg intravenous (n = 15) or 0.9% saline (control, n immediately before aortic cannulation for bypass.Neutrophil elastase, tumor necrosis...
<title>Abstract</title> Background The COVID-19 pandemic has placed unprecedented pressure on global healthcare systems, severely affecting the intensive care unit (ICU) capacity. Therefore, this study explored association between prefecture-level ICU congestion and mortality in each prefecture of Japan. Methods This retrospective analyzed data from CRoss Icu Searchable Information System, covering all patients with who required mechanical ventilation or extracorporeal membrane oxygenation...
Appropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical ventilation intensive units during "surges" the number of cases. In contrast, lower outcomes are evident Japan using CRISIS [CRoss Icu Searchable Information System] data by national registry, ECMOnet COVID-19. This highlights need scientific analysis medical factors contributing to high...
Background: Because it remains unclear whether noninvasive ventilation (NIV) is an effective therapy for cardiogenic pulmonary edema secondary to acute myocardial infarction (AMI), we retrospectively evaluated our experience with NIV in the treatment of AMI and other cardiac conditions. Methods Results: The study group included 206 patients edema, divided into (53 patients) a non-AMI (153 patients). weaning rate from was similar groups (90.6% vs. 90.8%, P=0.950). Heart rate, blood pressure,...
The coronavirus disease 2019 (COVID-19) pandemic has increased the number of patients who require extracorporeal membrane oxygenation (ECMO). To manage demand for ECMO, Japan ECMOnet COVID-19 was developed as a “disaster management-like system”, utilizing Cross ICU Searchable Information System (CRISIS) database. This study investigated effect establishment this disaster system in Japan. nationwide retrospective observational conducted from 1 February to 31 July 2020. A total 187 with...
Multisystem inflammatory syndrome in adults (MIS-A) is a hyperinflammatory multisystem condition associated with coronavirus disease (COVID-19). Critically ill COVID-19 patients may develop multiorgan damage and elevated responses, thus making it difficult to differentiate between progression organ due itself or MIS-A. This study aimed explore the characteristics complications of MIS-A critical patients.
We investigated the effects of nasal continuous positive airway pressure (CPAP) on plasma endothelin-1 (ET-1) concentrations in patients with cardiogenic pulmonary edema. Thirty were randomly assigned to two groups: 15 who received oxygen plus CPAP (CPAP group), and only by face mask (oxygen group). The heart rate mean artery decreased significantly group. PaO2/fraction inspired (FIO2) ratio increased group (163 +/- 70 332 104, P < 0.01) after 6 h was higher than that Arterial ET-1 from 6.2...
In Brief Dexmedetomidine hydrochloride is a potent, highly selective α-2 adrenergic receptor agonist, broadly used as sedative drug in intensive care units. We describe the case of 59-yr-old patient who experienced fever caused by dexmedetomidine hydrochloride. The was transferred to unit with an abdominal aortic aneurysm rupture. After initiation sedation hydrochloride, he developed pyrexia more than 39°C. This symptom improved rapidly 7 h after stopping Other possible causes (such...
Landiolol hydrochloride is a new β-adrenergic blocker with pharmacological profile that suggests it can be administered safely to patients who have sinus tachycardia or tachyarrhythmia and require heart rate reduction. This study aimed investigate whether intraoperative administration of landiolol could reduce the incidence atrial fibrillation (AF) after cardiac surgery. Of 200 consecutive whose records retrieved between October 2006 September 2007, we retrospectively reviewed total 105 met...
The survival rate of patients with critical coronavirus disease-19 (COVID-19) over time is inconsistent in different settings. In Japan, a national database was organized to monitor and share the patient generation across country an immediate response COVID-19 pandemic. This study aimed evaluate changes prognostic factors receiving mechanical ventilation with/without extracorporeal membrane oxygenation (ECMO) using largest Japan.This prospective observational cohort admitted intensive care...
Cardiac ruptures after myocardial infarction are classified as ventricular free wall (FWR), septal (VSR), and papillary muscle (PMR). A combination of any two types rupture is called "ventricular double rupture;" (VDR) shows a specific clinical course.3,284 patients with acute (AMI) were admitted to the CCU our hospital between April, 1973 December, 2001, 10 (8 males 2 female, aged 54∼82 years) VDR clinicopathologically evaluated. All diagnosed consisting FWR VSR. was observed in 0.30% all...