A5049682145- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
Stanford University
2022-2025
Abstract Naturally‐derived cell membranes have shown great promise in functionalizing nanoparticles to enhance biointerfacing functions for drug delivery applications. However, its potential macroporous scaffolds tissue regeneration vivo remains unexplored. Engineering with immunomodulatory represents an exciting strategy but is largely limited soft tissues. Critical‐sized bone defects cannot heal on their own, and the role of adaptive immune cells scaffold‐mediated healing cranial unknown....
Tissue-derived extracellular matrix (tdECM) hydrogels serve as effective scaffolds for tissue regeneration by promoting a regenerative immune response. While most tdECM are nanoporous and tailored soft tissue, macroporosity is crucial bone regeneration. Yet, there's shortage of macroporous ECM-based this purpose. The study aims to address gap developing co-spinning technique integrate bone-derived ECM (bECM) into gelatin-based, microribbon (µRB) scaffolds. effect varying doses bECM on...
Rationale: Mineral particles have been widely used in bone tissue engineering scaffolds due to their osteoconductive and osteoinductive properties.Despite benefits, mineral can induce undesirable inflammation subsequent resorption.Aspirin (Asp) is an inexpensive anti-inflammatory drug.The goal of this study assess the synergistic effect Asp optimized particle coating macroporous accelerate endogenous regeneration reduce resorption a critical-sized defect model.Methods: Four commonly with...